Agreement and repeatability of four different devices to measure non-invasive tear breakup time (NIBUT)

Bandlitz, Stefan; Peter, Barbara; Pflugi, Tanja; Jaeger, Kai; Anwar, Aaisha; Bikhu, Paramdeep; Nosch, Daniela; Wolffsohn, James S.

doi:10.1016/j.clae.2019.10.012

Cited by 5 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It can serve as an interferometer for the observation of the tear film lipid layer and allows for the measurement of noninvasive tear breakup time after inserting a grid. 30 It is similar to the Tearscope (Keeler Ltd., Windsor, United Kingdom), but it contains an integrated stopwatch and a light-emitting diode that can be used as a light source. It can be used as a handheld device, or it can be connected to a slit lamp.…”

mentioning

confidence: 99%

Assessment of Tear Film Parameters in Smokers and Subjects with a High Body Mass Index

Fagehi¹,

El‐Hiti

Almojalli

et al. 2022

Optom Vis Sci

View full text Add to dashboard Cite

SIGNIFICANCE:The current study compares the ocular tear film parameters in three different groups using a single noninvasive, practical, and easy-to-use tool.PURPOSE: This study aimed to assess the tear film in smokers, those with a high body mass index (BMI), and healthy subjects using the EASYTEAR view+.METHODS: Thirty men with a high BMI (>25 kg/m 2 ; 24.4 ± 6.4 years), 30 smokers (25.1 ± 6.1 years), and 30 healthy subjects (22.2 ± 3.5 years) were recruited. Each subject completed the Ocular Surface Disease Index, followed by the assessment of noninvasive tear breakup time, tear meniscus height (TMH), and lipid layer patterns (LLPs).RESULTS: Significant differences were found in the median TMH scores between smokers and healthy subjects ( P = .03) and between subjects with a high BMI and the healthy ones ( P = .04). The median LLP score was significantly ( P < .001) higher in normal subjects (4.0 [1.0]) than in smokers (2.4 [1.0]) and subjects with high BMI (2.0 [1.3]). For subjects with a high BMI, the noninvasive tear breakup time score was strongly correlated (Spearman rank correlation coefficient; r) with TMH (r = 0.552, P = .002) and LLP (r = 0.555, P = .001). The LLP showed that grade B (lipid layer thickness, 30 to 50 nm; more compact) was common in subjects with a high BMI, grade C (50 to 80 nm, gray waves) was predominant in smokers, and grade D (~80 nm, dense white-blue layer) represented the majority of normal eye subjects.CONCLUSIONS: Smokers and individuals with a high BMI showed significantly lower lipid layer grades and tear meniscus height scores compared with the control group. The assessment of tear film parameters using the EASYTEAR view+ supports the findings of previous studies that implicate smoking and high BMI as risk factors for dry eye.

show abstract

mentioning

confidence: 99%

Assessment of Tear Film Parameters in Smokers and Subjects with a High Body Mass Index

Fagehi¹,

El‐Hiti

Almojalli

et al. 2022

Optom Vis Sci

View full text Add to dashboard Cite

show abstract

“…16,26,27 As per the Tear Film and Ocular Surface Society Dry Eye Workshop II (TFOS DEWS II), the cutoff value for noninvasive tear breakup time is ≥10 seconds for normal eyes; using traditional methods, similar cutoff values were also reported by other studies. 22,28,29 In the present study, noninvasive tear breakup time is a marker of the stability of the pre-corneal tear film with a cutoff value of <10 seconds. In the 4-week study, improvement in tear breakup time was greater than the clinically meaningful level of 2.5 seconds.…”

Section: Discussionmentioning

confidence: 85%

“…The ring pattern can be illuminated by white or infrared light. This instrument measurement results in two outcomes, the first disruption in the projected placido rings (noninvasive tear breakup time first) and an average tear film breakup of the sections across the cornea (noninvasive tear breakup time average) 22 …”

Section: Methodsmentioning

confidence: 99%

“…This instrument measurement results in two outcomes, the first disruption in the projected placido rings (noninvasive tear breakup time first) and an average tear film breakup of the sections across the cornea (noninvasive tear breakup time average). 22 The second key exploratory objective included change from baseline in the IDEEL-SB module score at 12 months after single treatment in meibomian gland dysfunction subjects with evaporative dry eye. The IDEEL-SB consists of 20 questions that assessed general dry eye symptoms experienced by patients ranging from 0 to 100.…”

Section: Study End Pointsmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Two Thermal Pulsation Systems in the Treatment of Meibomian Gland Dysfunction: A Randomized, Multicenter Study

Wesley

Bickle²,

Downing

et al. 2022

Optom Vis Sci

View full text Add to dashboard Cite

SIGNIFICANCE: Given the significance of meibomian gland dysfunction subjects in evaporative dry eye, its chronic and progressive nature, limited promising treatment options, and novel treatment techniques are important. This randomized clinical study evaluated the noninferiority of SYSTANE iLux with LipiFlow in meibomian gland dysfunction treatment at 12 months. PURPOSE: This study aimed to demonstrate noninferiority of SYSTANE iLux compared with LipiFlow at 12 months after single treatment in meibomian gland dysfunction subjects with evaporative dry eye. METHODS: In this prospective, randomized, multicenter, assessor-masked, parallel-group trial, subjects (N = 236; aged ≥18 years) with meibomian gland score (MGS) of ≤12 in lower eyelids, noninvasive tear breakup time (NITBUT; first breakup) of <10 seconds, and Impact of Dry Eye on Everyday Life-Symptom Bother (IDEEL-SB) module score of >16 were randomized (1:1) to receive SYSTANE iLux (n = 119) or LipiFlow (n = 117). Subjects attended a total of eight visits, including screening, treatment, and follow-up visits at 2 weeks and at 1, 3, 6, 9, and 12 months/ exit, to evaluate change from baseline in MGS, NITBUT, IDEEL-SB module score, and safety outcomes.RESULTS: A total of 227 subjects completed the study (mean ± standard deviation age, 57.3 ± 13.8 years). At 12 months, least squares mean change from baseline in MGS was similar between iLux and LipiFlow (17.4 ± 1.97 vs. 17.8 ± 1.98). Noninferiority of SYSTANE iLux compared with LipiFlow in change from baseline in MGS (95% lower confidence limit of least squares mean difference, >−5), NITBUT (>−2.5 seconds), and IDEEL-SB score (95% upper confidence limit, <12) was achieved at all post-treatment visits. No other serious ocular or device-related adverse events were reported. CONCLUSIONS:The treatment outcomes with SYSTANE iLux were noninferior to LipiFlow during the 12-month follow-up in subjects with dry eye-associated meibomian gland dysfunction.

show abstract

“…Bandlitz et al [17] recently reported that objective measurement of the NIBUT using the Keratograph 5 M (Oculus Optikgeräte GmbH, Wetzlar, Germany) showed good repeatability and reasonable agreement with subjective NIBUT measurement using the Tearscope Plus (Keeler, Windsor, UK), Polaris (bon Optic, Lübeck, Germany), and EasyTear Viewplus (Easytear, Rovereto, Italy), which also support viability of the NIBUT in the diagnosis and treatment of DED [15].…”

Section: Noninvasive Tear Break-up Time (Nitbut)mentioning

confidence: 80%

Objective Imaging Diagnostics for Dry Eye Disease

Han

Liu

Mohamed-Noriega

et al. 2020

Journal of Ophthalmology

View full text Add to dashboard Cite

Traditional diagnostic tests for dry eye disease (DED), such as fluorescein tear film break-up time and the Schirmer test, are often associated with poor reproducibility and reliability, which make the diagnosis, follow-up, and management of the disease challenging. Advances in ocular imaging technology enables objective and reproducible measurement of changes in the ocular surface, tear film, and optical quality associated with DED. In this review, the authors will discuss the application of various imaging techniques, such as, noninvasive tear break-up time, anterior segment optical coherence tomography, in vivo confocal microscopy, meibography, interferometry, aberrometry, thermometry, and tear film imager in DED. Many studies have shown these devices to correlate with clinical symptoms and signs of DED, suggesting the potential of these imaging modalities as alternative tests for diagnosis and monitoring of the condition.

show abstract

Agreement and repeatability of four different devices to measure non-invasive tear breakup time (NIBUT)

Cited by 5 publications

References 20 publications

Assessment of Tear Film Parameters in Smokers and Subjects with a High Body Mass Index

Assessment of Tear Film Parameters in Smokers and Subjects with a High Body Mass Index

Comparison of Two Thermal Pulsation Systems in the Treatment of Meibomian Gland Dysfunction: A Randomized, Multicenter Study

Objective Imaging Diagnostics for Dry Eye Disease

Contact Info

Product

Resources

About