Agreeing Language in Veterinary Endocrinology (ALIVE): Diabetes mellitus - a modified Delphi-method-based system to create consensus disease definitions

Niessen, Stijn; Bjornvad, Charlotte; Church, David; Davison, Lucy; Esteban-Saltiveri, Diego; Fleeman, L. M.; Atienza, Yaiza Forcada; Fracassi, Federico; Gilor, Chen; Hanson, Jeanette; Herrtage, M. E.; Lathan, Patty; Leal, Rodolfo Oliveira; Loste, A.; Reusch, Claudia E; Schermerhorn, Thomas; Stengel, Christiane; Thoresen, S. I.; Thuróczy, Julianna

doi:10.1016/j.tvjl.2022.105910

Cited by 28 publications

(46 citation statements)

References 9 publications

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“…Owners who participated could represent a more motivated fraction. The definitions of diabetes mellitus and diabetic remission used in the study were formulated to fit owners, and did not conform to internationally agreed definitions, 45 which might limit comparison with other studies. To reduce the risk of overestimating survival time, since time frames were set as the year of diagnosis and death, and not a specific date, survival time was recorded from 31 December in the year of diagnosis to 1 January in the year of death.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Survival, remission, and quality of life in diabetic cats

Rothlin-Zachrisson

Öhlund

Röcklinsberg

et al. 2023

Veterinary Internal Medicne

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Background Remission is documented in a substantial proportion of cats with diabetes. The effects of diabetes mellitus (DM) on the lives of cats and their owners should be considered when evaluating treatment success. Objectives To study outcome in cats with DM and the impact DM has on the life situation of cat and owner. Animals Domestic and pedigree cats with a diagnosis of DM (n = 477) insured by a Swedish insurance company during 2009 to 2013. Methods Retrospective cross‐sectional study. A questionnaire was sent to 1369 owners of cats diagnosed with DM. The questions concerned the cat, treatment, owner perceptions of the disease and treatment and disease outcome. Data were analyzed using multiple linear and logistic regression, with outcomes set as survival for more than 4 weeks after diagnosis, survival time, achieving remission, remission without relapse and quality of life (QoL) for the cat. Results The response rate was 35%, leaving 477 questionnaires for analysis. The remission rate among treated cats was 29% (118/405). Feeding a commercially available wet diet was associated with both remission (OR 3.16, 95% confidence interval 1.27‐8.12) and remission without relapse (OR 14.8, 95% confidence interval 2.25‐153.8). Remission was associated with a better QoL for the cat. Conclusions and Clinical Importance The association between feeding a commercially available wet diet and remission is important and strengthens the role of diet in treatment of DM in cats. Linking remission and a better QoL for the cat emphasizes remission as a goal in disease management.

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Section: Limitations Of the Studymentioning

confidence: 99%

Survival, remission, and quality of life in diabetic cats

Rothlin-Zachrisson

Öhlund

Röcklinsberg

et al. 2023

Veterinary Internal Medicne

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“…2,3 The picture is probably multifactorial (Fig 1), involving both beta-cell-related disorders (insulindeficient CDM) and peripheral insulin resistance (insulin-resistant CDM). 1,4 Both conditions seem to be the result of complex genetic factors and environmental interactions. 1,4,5 These concepts are reflected in the definition of DM produced by the European Society of Veterinary Endocrinology's ALIVE (Agreeing Language in Veterinary Endocrinology) project, which defines DM as a heterogeneous group of diseases with multiple aetiologies characterised by hyperglycaemia resulting from inadequate insulin secretion, inadequate insulin action, or both.…”

Section: áLan Gomes Pöpplmentioning

confidence: 99%

“…1,4 Both conditions seem to be the result of complex genetic factors and environmental interactions. 1,4,5 These concepts are reflected in the definition of DM produced by the European Society of Veterinary Endocrinology's ALIVE (Agreeing Language in Veterinary Endocrinology) project, which defines DM as a heterogeneous group of diseases with multiple aetiologies characterised by hyperglycaemia resulting from inadequate insulin secretion, inadequate insulin action, or both. 4 DM is one of the most common endocrinopathies in dogs, 6 and some environmental factors causing insulin resistance are easily avoided.…”

Section: áLan Gomes Pöpplmentioning

confidence: 99%

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Canine diabetes mellitus: assessing risk factors to inform preventive measures

Pöppl

2023

Veterinary Record

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“…Sixteen were male and seven were female (all neutered); the median age was 11 years (range 6-17); mean body weight was 5.5 kg (range 3. [4][5][6][7][8][9][10][11][12].…”

Section: Serum Igf-1 Concentrationmentioning

confidence: 99%

Prevalence of hypersomatotropism and hyperthyroidism in cats with diabetes mellitus from referral centers in Buenos Aires (2020–2022)

Miceli

García

Amunategui

et al. 2023

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to estimate the prevalence of hypersomatotropism (HST) and hyperthyroidism in cats with diabetes mellitus (DM) from referral centers in Buenos Aires, Argentina. Methods This was a prospective study. Systematic screening of serum insulin-like growth factor 1 (IGF-1) and total thyroxine was performed in all cats diagnosed with DM at referral centers in Buenos Aires between February 2020 and February 2022. Results In total, 154 diabetic cats were evaluated (99 males and 55 females; median age 12 years [range 3–21]; mean body weight 5 kg [range 2–12]). Altogether, there were 115 (75%) domestic shorthairs and one domestic longhair; the remaining 38 cats were purebred (mainly Siamese, n = 25 [16%]). Twenty (12.9%) cats had IGF-1 concentrations >1000 ng/ml, and three (1.9%) had IGF-1 concentrations between 800 and 1000 ng/ml along with pituitary enlargement on CT, resulting in a 14.9% HST prevalence rate in diabetic cats. Intracranial imaging was performed in all cats with HST; median pituitary dorsoventral height was 5.8 mm (range 3.1–9.5). Fourteen of 23 (61%) cats had phenotypic changes consistent with acromegaly at the time of diagnosis of HST. Four of 154 (2.5%) cats had concurrent hyperthyroidism. Conclusions and relevance To date, this is the first study outside of Europe to have evaluated the prevalence of HST and hyperthyroidism in cats with DM. In Buenos Aires referral centers, feline HST is the most common concurrent endocrinopathy in cats with DM but with a lower prevalence than has previously been reported. Hyperthyroidism is a rare concurrent endocrinopathy in diabetic cats from referral centers in Buenos Aires.

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Agreeing Language in Veterinary Endocrinology (ALIVE): Diabetes mellitus - a modified Delphi-method-based system to create consensus disease definitions

Cited by 28 publications

References 9 publications

Survival, remission, and quality of life in diabetic cats

Survival, remission, and quality of life in diabetic cats

Canine diabetes mellitus: assessing risk factors to inform preventive measures

Prevalence of hypersomatotropism and hyperthyroidism in cats with diabetes mellitus from referral centers in Buenos Aires (2020–2022)

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