Agranulocytosis due to the Occurrence of Leukocyte-Agglutinins

Moeschlin, S; Wagner, Kay Cimpl

doi:10.1159/000204146

Cited by 213 publications

(44 citation statements)

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“…Moreover, it appears that nuclear material from many different species and varying human tissues can be made to participate in this reaction (45,(50)(51)(52)(53) (56)(57)(58). The leukopenia, often a neutropenia, has been variously attributed to chronic infection (57), hypersplenism (56,(58)(59)(60), leukocyte agglutinins (17) or unknown causes (61). It is well recognized that a positive L.E.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…factor may be responsible for the development of the leukopenia commonly seen in SLE (46,66 (4,6,17,(67)(68)(69). Pre-sumably the fever was secondary to the release of tissue pyrogens from destroyed leukocytes (6,70,71); however, notwithstanding sterile cultures, the possible presence of bacterial pyrogens cannot be entirely excluded (72).…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…Similarly, the effects of drug sensitivity have been recognized to affect any or all of the three formed elements of the peripheral blood (14)(15)(16)(17)(18)(19)(20). Evidence has also been presented that in patients requiring multiple transfusions, powerful leukocyte antibodies may be produced and give rise to undue reactions (21)(22)(23).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Fluorescent Antiglobulin Studies in Leukopenic and Related Disorders *

Calabresi¹,

Edwards²,

Schilling³

1959

J. Clin. Invest.

106

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Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Fluorescent Antiglobulin Studies in Leukopenic and Related Disorders *

Calabresi¹,

Edwards²,

Schilling³

1959

J. Clin. Invest.

106

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“…A possibly different kind of agglutinin for white cells, such as that related to aminopyrine leukopenia, has also been described (7). The therapeutic administration of blood and of aminopyrine may not be the only stimuli for leukoagglutinin production.…”

mentioning

confidence: 99%

Fetomaternal Leukocyte Incompatibility

Payne

Rolfs

1959

Obstetrical & Gynecological Survey

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Iso-leukoagglutinins are known to develop primarily in multitransfused patients (1-6). A possibly different kind of agglutinin for white cells, such as that related to aminopyrine leukopenia, has also been described (7). The therapeutic administration of blood and of aminopyrine may not be the only stimuli for leukoagglutinin production. Two groups of investigators, Dausset, Nenna and Brecy (8) and Whyte and Yee (9), have drawn upon the analogy to Rh antibody formation, and have discussed the possibility that fetal leukocyte antigens might act as stimuli to the mother. Killman (10) considered this potential source of antigen in his investigations of leukoagglutinins in collagen diseases, but he was unable to find any correlation between pregnancies and leukoagglutinin formation. The studies presented in this paper demonstrate that fetomaternal leukocyte incompatibility may induce leukoagglutinin formation in the mother, and suggest that some leukocyte factors, as demonstrated by their corresponding leukoagglutinins, may be genetically transmitted to the offspring. METHODSTechnique of the test for leukoagglutinins. The details of the test for leukoagglutinins were presented in previous publications (2, 3). In this study, the test leukocytes for iso-leukoagglutinins were obtained from 10 persons of red cell blood group 0; these were healthy donors whose red cells differed in their Rh factors. All inactivated sera were tested against the entire panel of 10 leukocyte donors. A leukoagglutinin test was considered positive when different samples of serum obtained from the same individual produced compact clumping of the leukocytes of a panel member on two different occasions. The sera selected as positive in this series were those which produced clumping of two or more members of the leukocyte panel. Weakly reacting sera were occasionally observed. These induced very weak clump-' This study was supported by Research Grant H-3365, National Institutes of Health, United States Public Health Service.2 Presented before the Western Society for Clinical Research, Carmel, Calif., Jan. 30 through Feb. 1, 1958. ing, or only agglutinated one member of the leukocyte panel. They were arbitrarily not included among the positive sera. Some of the weak reactions could be attributed to the adherence of leukocytes to noncellular material in serum; others seemed to be related to the gradual deterioration of the test leukocytes with time. In order to minimize these sources of error, fresh leukocytes were obtained daily. Different members of the leukocyte panel reacted with a single test serum so as to give titer differences no greater than those inherent in the serial dilution method of titration. The patients' own leukocytes were employed in tests for autoleukoagglutinins. When red cell antibodies other than anti-A or anti-B were present in test sera the test leukocytes were selected so that the accompanying red blood cells would not contain the conflicting factors. In family studies, in which sera from persons of one ABO blood gro...

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“…Leucocyte agglutinins have been demonstrated in various clinical conditions including lupus erythematosus (6), aleukemic leukemia (6), pancytopenia (6, 7), agranulocytosis due to pyramidon (8) and chronic neutropenia (9). Some have implicated these agglutinins as the causative factors for the leukopenia in these diseases.…”

mentioning

confidence: 99%

Some Studies on the Naturally Occurring Leucocyte Agglutinins 12

Butler¹

1956

J. Clin. Invest.

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Agranulocytosis due to the Occurrence of Leukocyte-Agglutinins

Cited by 213 publications

References 0 publications

Fluorescent Antiglobulin Studies in Leukopenic and Related Disorders *

Fluorescent Antiglobulin Studies in Leukopenic and Related Disorders *

Fetomaternal Leukocyte Incompatibility

Some Studies on the Naturally Occurring Leucocyte Agglutinins 12

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