Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity

Çankara, Fatma Nihan; Günaydın, Caner; Çelik, Zülfinaz Betül; Şahi̇n, Yasemin; Pekgöz, Şakir; Erzurumlu, Yalçın; Gülle, Kanat

doi:10.1007/s11011-020-00634-y

Cited by 22 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following CP injection, a significant elevation of the inflammatory cytokine concentrations of IL-1β and IL-6 in the brain tissue was detected in our study, confirming the presence of neuroinflammation. These findings are in line with those of other reports [21,24,25].…”

Section: Discussionsupporting

confidence: 94%

“…Large quantities of NO have been found to be produced under oxidative stress by iNOS, with the subsequent formation of peroxynitrite, which causes a consequent damaging effect due to GSH level depletion and antioxidant cellular activity suppression [23]. After CP injection, our study presented a significant rise in the lipid peroxidation product MDA in addition to the NO content, along with a significant decline in GSH and SOD levels in the brain tissue, and these results were in line with those of other previous studies [6,24,25].…”

Section: Discussionsupporting

confidence: 92%

“…Cisplatin induced neurotoxicity as the neuronal cells are more vulnerable to oxidative stress because of their insufficient antioxidant defenses and raised lipid contents [31]. Therefore, possible interventions to mitigate the neurotoxicity induced by CP have been investigated through concurrent treatment with agents with antioxidant capability [24]. Moreover, inhibition of the inflammatory mediators and suppression of apoptosis could be targets for neuroprotection [24,25,27].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, possible interventions to mitigate the neurotoxicity induced by CP have been investigated through concurrent treatment with agents with antioxidant capability [24]. Moreover, inhibition of the inflammatory mediators and suppression of apoptosis could be targets for neuroprotection [24,25,27].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

2021

View full text Add to dashboard Cite

Cisplatin (CP) is extensively used in the medical oncology field for malignancy treatment, but its use is associated with neurological side effects that compromise the patients’ quality of life. Cytotherapy is a new treatment strategy for tissue damage that has recently emerged. The use of bone marrow-derived mesenchymal stem cells (BM-MSCs) was investigated for its therapeutic potential against CP-induced chemobrain as well as various models of brain damage. This study was carried out to elucidate, for the first time, the role of the intravenous injection (IV) of BM-MSCs against CP-induced neurotoxicity in a rat model through investigation of the parameters of oxidative stress, inflammation, and apoptosis in brain tissue. A rat model of neurotoxicity was generated by intraperitoneal injection of 7.5 mg/kg CP while 2 × 106 BM-MSCs was given by IV as a therapeutic dose. Injection of CP led to a significant rise in malondialdehyde and nitric oxide levels accompanied by a marked depletion of superoxide dismutase and reduced glutathione content in brain tissue in comparison to the normal control (NC) rats. Furthermore, a remarkable rise in the brain levels of inflammatory cytokines interleukin (IL)-1β and IL-6, together with the expression of apoptotic marker caspase-3, and the downregulation of the brain expression of proliferating marker Ki-67 in brain tissue were detected in the CP group compared to the NC group. Histopathological alterations were observed in the brain tissue of the CP group. BM-MSCs mitigated the biochemical and histopathological alterations induced by CP without affecting brain cell proliferation. BM-MSCs could be used as a promising neuroprotective agent against CP-induced neurotoxicity.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

2021

View full text Add to dashboard Cite

show abstract

“…Accumulating evidence suggests that elevated inflammation contributes to the pathophysiology of anxiety disorders, such as post-traumatic stress disorder (PTSD) [ 173 ], and that anti-inflammatory drugs might be a new treatment strategy for PTSD [ 188 ]. Various clinically used anxiolytics have other actions and target redox-inflammatory processes indirectly, such as agomelatine [ 189 ] and the SSRIs [ 190 ]. These drugs are approved for the management of chronic anxiety-related disorders [ 190 ].…”

Section: The Association Between Stress Inflammation and Treatment Rmentioning

confidence: 99%

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Vuren

Steyn

Brink

et al. 2021

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Melatonin is effective in attenuating cisplatin‐induced neurotoxicity

Bayraktar

Arıhan

Atalay

et al. 2022

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Cisplatin (Cis) is a chemotherapeutic agent that has many side effects. Neurotoxicity is one of the most important of these side effects. Oxidative stress and neuroinflammation are the best‐known mechanisms in the pathogenesis of neurotoxicity development. In this study, we aimed to determine whether melatonin (Mel), with antioxidant and anti‐inflammatory effects, is effective in preventing Cis‐induced neurotoxicity. Forty‐eight male Sprague–Dawley rats were divided into six groups (n = 8) as follows: control (0.9% NaCl), vehicle (5% ethanol), Cis (6 mg/kg), Cis (6 mg/kg) + vehicle (5% ethanol), Mel (20 mg/kg), and Cis (6 mg/kg) + Mel (20 mg/kg) groups. Cis was administered as a single dose on the 3rd day of the experiment while Mel was given for 5 days. All administrations were performed via intraperitoneal injection. After injections, T‐maze, rotarod, and hot plate tests were performed to evaluate cognitive, motor, and sensory functions, respectively. Following sacrification oxidative stress markers, cholinergic function, and proinflammatory cytokines were studied from brain homogenates. Cis impaired cognitive function and motor performance in the Cis and Cis+Vehicle groups. The drug also increased oxidative stress in the brain. Mel significantly improved brain oxidant/antioxidant status and also decreased the overproduction of proinflammatory cytokines (superoxide dismutase activities in Cis+Vehicle and Cis+Mel groups: 104.55 ± 9.50 µU/mg protein vs. 150.13 ± 4.70 µU/mg protein, respectively, p < 0.05; tumor necrosis factor‐α levels in Cis and Cis+Mel groups: 40 pg/ml vs. 20 pg/ml, respectively, p < 0.05). It seems that Mel can improve Cis neurotoxicity. For a more firm conclusion, further studies using Mel at different doses with larger groups should be performed.

show abstract

Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity

Cited by 22 publications

References 28 publications

Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

Neuroprotective Potential of Bone Marrow-Derived Mesenchymal Stem Cells Following Chemotherapy

The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment

Melatonin is effective in attenuating cisplatin‐induced neurotoxicity

Contact Info

Product

Resources

About