Agnostic Administration of Targeted Anticancer Drugs: Looking for a Balance between Hype and Caution
Svetlana N. Aleksakhina,
Alexander O. Ivantsov,
Evgeny N. Imyanitov
Abstract:Many tumors have well-defined vulnerabilities, thus potentially allowing highly specific and effective treatment. There is a spectrum of actionable genetic alterations which are shared across various tumor types and, therefore, can be targeted by a given drug irrespective of tumor histology. Several agnostic drug-target matches have already been approved for clinical use, e.g., immune therapy for tumors with microsatellite instability (MSI) and/or high tumor mutation burden (TMB), NTRK1-3 and RET inhibitors fo… Show more
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