AgNOR as an effective diagnostic tool for determining the proliferative nature of different types of odontogenic cysts

Tyagi, Krishan Kumar; Chandra, Lokesh; Kumar, Manoj; Singh, Sameep; Passi, Deepak; Goyal, Jyoti; Gupta, Utkarsh

doi:10.4103/jfmpc.jfmpc_617_19

Cited by 8 publications

(3 citation statements)

References 15 publications

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“…If these areas are active, they can be stained with silver. Due to silver, these proteins are called Argyrophilic NOR (AgNOR) related proteins (Tyagi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway

et al. 2022

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In this study, the protective effect of melatonin was investigated in lipopolysaccharide induced sepsis model. Twenty‐eight rats were randomly divided: Control, Melatonin, LPS and LPS + Melatonin. After LPS application, surgically remove kidney and liver tissues. The level of malondialdehyde (MDA) an oxidative stress marker and the immunoreactivity of Toll‐like receptor‐4 (TLR4), tumor necrosis factor‐α (TNF‐α), and transcription factor NF‐κB were evaluated immunohistochemically. Expression levels for TLR4, TNF‐α, NF‐kB, IL‐1β (interleukin 1 beta), and IL‐6 (interleukin 6) were evaluated. Additionally, Argyrophilic NOR staining was performed in tissues. Vacuolization and inflammation were more intense in the kidney and liver sections in the LPS group compared to the other groups. It was observed that vacuolization and inflammation were decreased in LPS + Melatonin applied groups. It was determined that glomerular damage was increased in the LPS and LPS‐melatonin groups, but the damage rate LPS‐Melatonin group was decrease in the LPS group. It was determined that the MDA level in tissues of the LPS group was importantly increased compared to other groups. Additionally, TAA/NA ratio statistically significant differences were discovered between the groups. This study supports the potential protective effects of 10 mg/kg melatonin by modulating critical markers of local immune reaction in a model of LPS‐induced sepsis.

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“…If these areas are active, they can be stained with silver. Due to silver, these proteins are called Argyrophilic NOR (AgNOR) related proteins (Tyagi et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway

et al. 2022

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“…23 There are several studies on the importance of interphase AgNOR in tumor pathology for prognostic and diagnostic definitions of different types of cancer. 11,21,22,24…”

Section: Introductionmentioning

confidence: 99%

“…23 There are several studies on the importance of interphase AgNOR in tumor pathology for prognostic and diagnostic definitions of different types of cancer. 11,21,22,24 In the literature, there have been no studies on the application of different doses of quercetin, angiogenesis, and AgNOR protein determination on the EAC model. This study aims to investigate the antitumoral effect of quercetin in different doses on the EAC solid tumor model experimentally created in male mice of Balb/c type.…”

Section: Introductionmentioning

confidence: 99%

Detection of antitumoral effects of quercetin through protein synthesis associated with argyrophilic nucleolar-regulating region

2020

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Quercetin is a natural flavonoid with potential anticancer properties without significant cytotoxicity in normal tissues. However, the effects of quercetin on Ehrlich ascites carcinoma (EAC) have not yet been clarified. The study aimed to show the antitumoral effect of quercetin through argyrophilic nucleolar organizer region (AgNOR) protein synthesis in mice carrying EAC. Thirty mice were used in the experiment (negative control ( n = 6), tumor control ( n = 8), quercetin 50 mg/kg ( n = 8), and quercetin 100 mg/kg ( n = 8) intravenously). The animals were euthanized on the 14th day, and the solid tumors were removed. Then, the total AgNOR area/nuclear area (TAA/NA) and average AgNOR number were calculated for each mice and the immunoreactivity of the factor VIII protein in tumor was evaluated. Tumor volumes and animal weights were statistically significant compared to the tumor control group ( p < 0.05). Statistically significant differences were observed between the groups in terms of TAA/NA ratio ( p < 0.05). Factor VIII expressions decreased in quercetin groups compared to control tumor tissue ( p < 0.05). The current study showed that quercetin has an important function against cancer development.

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Influence of cryopreservation techniques and low concentrations of permeating cryoprotectants on the conservation of ear cartilage and skin derived from six-banded armadillos (Euphractus sexcinctus Linnaeus, 1758)

Fernandes,

Praxedes,

Viana

et al. 2023

Cryobiology

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AgNOR as an effective diagnostic tool for determining the proliferative nature of different types of odontogenic cysts

Cited by 8 publications

References 15 publications

Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway

Detection of melatonin protective effects in sepsis via argyrophilic nucleolar regulatory region‐associated protein synthesis and TLR4/NF‐κB signaling pathway

Detection of antitumoral effects of quercetin through protein synthesis associated with argyrophilic nucleolar-regulating region

Influence of cryopreservation techniques and low concentrations of permeating cryoprotectants on the conservation of ear cartilage and skin derived from six-banded armadillos (Euphractus sexcinctus Linnaeus, 1758)

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