Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice

Taksande, Brijesh G.; Faldu, Dharmesh S.; Dixit, Madhura P.; Sakaria, Jay N.; Aglawe, Manish M.; Umekar, Milind J.; Kotagale, Nandkishor R.

doi:10.1016/j.ejphar.2013.10.041

Cited by 62 publications

(39 citation statements)

References 45 publications

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“…However, the splash test unveiled a significant decrease in the grooming time in the METH group, which is indicative of decreased self‐care behavior, mimicking the apathy observed in depressed patients . Moreover, stress‐induced grooming perturbation is associated with reduced hedonic reactivity in the SPT . This is the first study evaluating whether METH induced anhedonic‐like behavior in mice, using SPT.…”

Section: Resultsmentioning

confidence: 73%

Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice

et al. 2016

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Section: Resultsmentioning

confidence: 73%

Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice

et al. 2016

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“…For example, certain microorganisms (for example, fungi) associated with pickled foods may enhance the production of N -nitroso compounds with potential carcinogenic properties [164]. Also, although agmatine and other polyamines found in fermented meats, fish, and certain beverages have been shown to have a variety of experimental benefits related to brain health [165,166], a safe level of intake remains unknown [165]. However, as outlined in our review, there is more than ample justification to follow the microbe-nutrition and gut-brain research pathways into convergence.…”

Section: Discussionmentioning

confidence: 99%

Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry

Selhub

Logan²,

Bested

2014

J Physiol Anthropol

210

130

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The purposeful application of fermentation in food and beverage preparation, as a means to provide palatability, nutritional value, preservative, and medicinal properties, is an ancient practice. Fermented foods and beverages continue to make a significant contribution to the overall patterns of traditional dietary practices. As our knowledge of the human microbiome increases, including its connection to mental health (for example, anxiety and depression), it is becoming increasingly clear that there are untold connections between our resident microbes and many aspects of physiology. Of relevance to this research are new findings concerning the ways in which fermentation alters dietary items pre-consumption, and in turn, the ways in which fermentation-enriched chemicals (for example, lactoferrin, bioactive peptides) and newly formed phytochemicals (for example, unique flavonoids) may act upon our own intestinal microbiota profile. Here, we argue that the consumption of fermented foods may be particularly relevant to the emerging research linking traditional dietary practices and positive mental health. The extent to which traditional dietary items may mitigate inflammation and oxidative stress may be controlled, at least to some degree, by microbiota. It is our contention that properly controlled fermentation may often amplify the specific nutrient and phytochemical content of foods, the ultimate value of which may associated with mental health; furthermore, we also argue that the microbes (for example, Lactobacillus and Bifidobacteria species) associated with fermented foods may also influence brain health via direct and indirect pathways.

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“…The duration of this immobility is supposed to represent a measure of a depressive-like state. The higher immobility duration associated with CUMS-induced anhedonia has been demonstrated in several studies (Briones et al 2012, Elizalde et al 2008, Fu et al 2016, Strekalova et al 2004, Taksande et al 2013). Interestingly, a statistically significant correlation was only found between the cognitive deficits and immobility in the FST induced by CUMS but not the anhedonia level (Elizalde et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Anhedonia but not passive floating is an indicator of depressive‑like behavior in two chronic stress paradigms

Stepanichev

Tishkina

Новикова

et al. 2016

Acta Neurobiologiae Experimentalis

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Depression is the most common form of mental disability in the world. Depressive episodes may be precipitated by severe acute stressful events or by mild chronic stressors. Studies on the mechanisms of depression require both appropriate experimental models (most of them based on the exposure of animals to chronic stressors), and appropriate tests for assessment of depressive states. In this study male Wistar rats were exposed to two different chronic stress paradigms: an eight-week chronic unpredictable mild stress or a two-week combined chronic stress. The behavioral effects of stress were evaluated using sucrose preference, forced swim and open field tests. After the exposure to chronic unpredictable mild stress, anhedonia was developed, activity in the open field increased, while no changes in the duration of passive floating could be detected. After chronic combined stress, anhedonia was also evident, whereas behavior in the open field and forced swim test did not change. The levels of corticosterone in the blood and brain structures involved in stress-response did not differ from control in both experiments. The absence of significant changes in corticosterone levels and passive floating may be indicative of the adaptation of animals to chronic stress. Anhedonia appears to be a more sensitive indicator of depressive-like behavioral effects of chronic stress as compared to behavior in the forced swim or open field tests.

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Agmatine attenuates chronic unpredictable mild stress induced behavioral alteration in mice

Cited by 62 publications

References 45 publications

Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice

Methamphetamine Induces Anhedonic‐Like Behavior and Impairs Frontal Cortical Energetics in Mice

Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry

Anhedonia but not passive floating is an indicator of depressive‑like behavior in two chronic stress paradigms

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