Ağır amitriptilin zehirlenmesi ve plazmaferez

Abstract

Sum maryTricyclic antidepressant intoxication is one of the most frequently seen and life-threatening causes of intoxication among referrals to emergency departments because of drug intoxication. Especially in children, it is a major cause of mortality and morbidity. Intoxication symptoms are observed in the early phase because of a high volume of distribution and a high degree of plasma protein binding. Plasmapheresis is very effective in poisonings with amitriptyline, theophylline, diltiazem, carbamazepine, L-thyroxin, verapamil and heavy metals including mercury. American Apheresis Association Guide recommends plasmapheresis to support primary treatment in drug poisonings which do not respond to certain and traditional treatments. In this report, we wanted to emphasize that plasmapheresis treatment was successful in two subjects who presented with amitriptyline intoxication. (Turk Arch Ped 2012; 47: 214-215)