Aging with HIV in Latin America and the Caribbean: a Systematic Review

Cabrera, Diego M.; Diaz, Monica M.; Grimshaw, Alyssa; Salvatierra, Justina; García, Patricia J.; Hsieh, Evelyn

doi:10.1007/s11904-020-00538-7

Cited by 13 publications

(11 citation statements)

References 87 publications

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“…Most of the subjects, who are in the AIDS phase in this study, present symptoms of depression in line with the few studies carried out in reference to this topic 12 , which shows a possible role of the neurotrophic factor derived from the brain in the symptoms of depression and other aspects of the state of mind that until now have been superficially studied. It has also been noted that there are more positive cases of depression as age increases, these results are in accordance with other studies carried out 13 . Age appears to be a predictor of comorbidity.…”

Section: Discussionsupporting

confidence: 92%

Depression is associated with CD4 levels in people living with HIV in Ecuador

Checa¹,

Navas²,

Valencia³

et al. 2021

RMN

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Section: Discussionsupporting

confidence: 92%

Depression is associated with CD4 levels in people living with HIV in Ecuador

Checa¹,

Navas²,

Valencia³

et al. 2021

RMN

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“…Una revisión sistemática en Latinoamérica y el Caribe mostró que los estudios de comorbilidades cardiovasculares y metabólicas en personas IpVIH se concentran sobre todo en mayores de 50 años, usuarios de IP y mujeres postmenopáusicas; y resalta que en la región faltan estudios longitudinales y validación de las herramientas disponibles para la adecuada evaluación del riesgo cardiovascular en la población de personas con IpVIH que tengan en cuenta factores socioculturales y genéticos que pudieran influir sobre el envejecimiento 9 .…”

Section: Discussionunclassified

“…La etiología de estas complicaciones se considera multifactorial e incluye las consecuencias de la infección por el propio VIH, la exposición crónica a la terapia antirretroviral (TARV), los procesos inflamatorios subyacentes y el estilo de vida del paciente. En Latinoamérica, algunos estudios hallaron una mayor prevalencia de dislipidemia entre adultos mayores con IpVIH que entre los más jóvenes, relativizando de esta forma la influencia de la TARV sobre los trastornos metabólicos y dando más importancia a la edad 9 . Por todo lo anterior, el manejo de los trastornos metabólicos es un aspecto fundamental del cuidado de estos pacientes [10][11] .…”

Section: Vih / Sidaunclassified

Impacto de la cuarentena por COVID-19 en el perfil metabólico de personas con infección por VIH en Argentina

Bottaro

Cecchini

Ballivian

et al. 2022

Rev. chil. infectol.

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Introducción: Para mitigar la propagación del SARS-CoV-2 se requirió de un confinamiento generalizado. Las autoridades argentinas impusieron aislamiento social preventivo durante 234 días (20 de marzo al 9 de noviembre de 2020), modificando el estilo de vida de la población. Objetivo: Examinar la influencia de las medidas de bloqueo en el perfil metabólico de pacientes infectados por VIH en Argentina. Pacientes y Métodos: Estudio de cohorte retrospectivo de 10.239 pacientes en seguimiento en una clínica de atención privada de personas con infección por VIH. Se incluyeron pacientes adultos con terapia antirretroviral (TARV) en curso que tuvieran una determinación de glucemia, colesterol total, colesterol HDL y trigliceridemia antes de la cuarentena (Pre-C: segundo semestre 2019) y una segunda determinación durante la misma (Intra-C: mayo 2020). Se excluyeron los pacientes con cambios en la TARV con impacto metabólico, los que iniciaron o suspendieron hipolipemiantes o hipoglucemiantes y mujeres embarazadas. Las variables categóricas se compararon mediante la prueba de la χ 2 o la prueba exacta de Fisher y las continuas mediante la prueba t o la prueba de Mann-Whitney según correspondiera. Se consideró significativo un valor de p a dos colas < 0,05. Resultados: Se incluyeron 540 individuos. La mediana de edad fue de 47 años y 74,6% fueron de sexo masculino. La mediana de índice de masa corporal fue 26,1 y 94,6% tenían bajo riesgo cardiovascular. Hubo un aumento significativo en el porcentaje de pacientes con hiperglucemia (Pre-C 5,2% vs Intra-C 8,5%, p 0,04), hipertrigliceridemia (Pre-C 33,9% vs Intra-C 40,7%, p 0,02) e hipercolesterolemia LDL (Pre-C 12,6% vs

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“…In Latin America & the Caribbean (LAC) few studies have focused on the impact of aging-related comorbidities among middle-aged and older PLWH. Therefore an important research agenda remains to characterize the epidemiology and outcomes of these co-morbidities taking into account sociocultural and health systems related factors unique to this region [4]. The musculoskeletal (MSK) system is significantly affected by HIV and its treatment.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Regional Body Composition, Physical Function and Sarcopenia among Peruvian women aging with HIV

Cabrera

Cornejo

Pinedo³

et al. 2022

Preprint

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Background Management of chronic conditions and optimization of overall health has become a primary global health concern in the care of people living with HIV, particularly in lower-and-middle income countries where infrastructure for chronic disease management may be fragmented. Alterations in body composition (BC) can reflect important changes in musculoskeletal health, particularly among populations at risk for developing fat and muscle redistribution syndromes, such as HIV-infected women. We aimed to explore this issue among Peruvian women aging with HIV. Methods Cross-sectional study among HIV-infected and uninfected Peruvian women aged >=40. Dual X-ray absorptiometry was used to measure trunk and limb lean mass (LM) and fat mass (FM). Physical performance was assessed with the Short Physical Performance Battery (SPPB) and physical strength with a dynamometer. Sarcopenia was assessed based upon EWGSOP criteria. We used linear regression to model associations between BC, sarcopenia and physical scores. Results 104 HIV-infected and 212 uninfected women were enrolled with a mean age of 55.1±8.8 years. Among the HIV-infected group, years since diagnosis was 11.8±6 and all were on antiretroviral treatment. Mean SPPB score was 9.9 vs 10.8 (p<0.001) between both groups. Sarcopenia spectrum was found in 25.9% of HIV-infected and 23.1% of uninfected women. In multivariate regression analysis, trunk FM and older age were negatively correlated with physical performance among HIV-infected women. An increased percentage of severe sarcopenia was found among the HIV-infected, although our study was not specifically powered for this comparison. Conclusions HIV-infected women had significantly lower SPPB scores compared to women without HIV, and trunk FM and upper limb LM were independent predictors for the tests described. Prospective studies are needed in Latin America & the Caribbean to identify individuals at high risk for declines in physical function, and inform prevention guidelines.

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Aging with HIV in Latin America and the Caribbean: a Systematic Review

Cited by 13 publications

References 87 publications

Depression is associated with CD4 levels in people living with HIV in Ecuador

Depression is associated with CD4 levels in people living with HIV in Ecuador

Impacto de la cuarentena por COVID-19 en el perfil metabólico de personas con infección por VIH en Argentina

Assessment of Regional Body Composition, Physical Function and Sarcopenia among Peruvian women aging with HIV

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