Aging Skin as a Diagnostic Tool for Internal Diseases: A Chance for Dermatology

Nikolakis, Georgios; Makrantonaki, Evgenia; Zouboulis, Christos C.

doi:10.1007/978-3-642-27814-3_125-1

Cited by 2 publications

(3 citation statements)

References 183 publications

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“…Ultraviolet (UV) radiation is regard as the reason of extrinsically aging [1]. Based on wavelength, solar UV has 3 main components, including UVA (320–400 nm), UVB (280–320 nm), and UVC (<280 nm).…”

Section: Introductionmentioning

confidence: 99%

Concentrated Growth Factors Can Inhibit Photoaging Damage Induced by Ultraviolet A (UVA) on the Human Dermal Fibroblasts In Vitro

et al. 2019

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Background Photoaging is the main cause of extrinsic skin aging. Daily exposure to ultraviolet A (UVA) accelerates the process of photoaging. The present study aimed to understand the role of concentrated growth factors (CGF) on UVA irradiated human skin cells. Material/Methods We isolated and subcultured normal human dermal fibroblasts (NHDFs) from 6 different human dorsal skins and established photoaging models of NHDFs irradiated by UVA to detect the influence of CGF on fibroblasts in vitro . Three groups were examined: normal, cellular photoaging model (total dosages of 18J·cm −2 ), and cellular photoaging model plus CGF. In our study, we used the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay method to measure the cell viability. We also used reactive oxygen species (ROS) assay and superoxide dismutase (SOD) assay to measure respectively the amount of oxygen free radicals and antioxidative enzymes. We compared the migration rates among the photoaging model groups, the control groups, and the CGF-treated culture medium groups that were irradiated. Results Our study results indicated that 5% CGF can reduce UVA-induced human skin fibroblasts damage significantly, improve the viability of NHDFs significantly, and largely decrease the UVA irradiation effect ( P <0.05). The migration rates of the normal group and the UVA-irradiated NHDFs in the 5% CGF group had significantly increased migration rates ( P <0.05), compared to the control medium group. The migration rates of the UVA-irradiated NHDFs in 5% CGF exceed those of the normal group. These results showed that 5% CGF could greatly promote cellular proliferation, migration, and SOD at the same time that the amounts of ROS were markedly decreased. Conclusions These experimental findings offer some important insights into CGF’s capacity for scavenging ROS, improving SOD, and increasing migration rates in NHDFs irradiated by UVA.

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Section: Introductionmentioning

confidence: 99%

Concentrated Growth Factors Can Inhibit Photoaging Damage Induced by Ultraviolet A (UVA) on the Human Dermal Fibroblasts In Vitro

et al. 2019

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“…Some of the pathophysiological manifestations of the aged skin are mainly related to an increase in cutaneous oxidative stress and free radical accumulation, together with a gradual decrease in collagen and mucopolysaccharides. These alterations are one of the main reasons for wrinkling and sagging as they result in deep modifications of the extracellular matrix function and the creation of a catalytic microenvironment 1 . The marked loss of fibrillin structures may also contribute to wrinkles by weakening the dermo‐epidermal junction.…”

Section: Introductionmentioning

confidence: 99%

“…These alterations are one of the main reasons for wrinkling and sagging as they result in deep modifications of the extracellular matrix function and the creation of a catalytic microenvironment. 1 The marked loss of fibrillin structures may also contribute to wrinkles by weakening the dermo-epidermal junction. The basement membrane presents a highly interconnected architecture rich in extracellular matrix proteins, such as collagen type IV, laminin, integrins and other adhesion molecules.…”

Section: Introductionmentioning

confidence: 99%

Combined therapy with Endoret‐Gel and plasma rich in growth factors vs Endoret‐Gel alone in the management of facial rejuvenation: A comparative study

Navarro¹,

Pino

Martínez‐Andrés³

et al. 2020

J of Cosmetic Dermatology

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Background Skin suffers progressive decrement. An endogenous regenerative technology has been developed that has the versatility to provide an autologous injectable gel (Endoret‐Gel) or a liquid plasma rich in growth factors (PRGF) based on the patient´s own platelet‐rich plasma. Aims To compare the efficacy of the combined therapy with Endoret‐Gel and PRGF versus Endoret‐Gel alone in the management of facial rejuvenation. Methods Twenty clinically diagnosed patients with aged skin received either Endoret‐Gel monotherapy or Endoret‐Gel + PRGF combined therapy. Patients underwent three sessions at one‐month intervals and were clinically assessed for six months. Corneometry, sebumetry, and high‐resolution topographic analysis were carried out. Patient self‐assessment questionnaires and clinical improvement scores were also performed. Results The combined therapy showed to promote a higher hydration index. These results were also significant for spot improvement at three months, while conversely, monotherapy with Endoret‐Gel demonstrated higher UV spot improvement. A significant decrease of sebum production and wrinkle development was observed for both treatment groups. Red areas also improved in a similar way at the end of the follow‐up period. After Endoret‐Gel or Endoret‐Gel + PRGF therapy, 30% and 70% of patients referred to be very satisfied, respectively. Accordingly, 40% and 80% showed a “very improved” esthetic performance. None of the patients reported a negative change and no adverse events were recorded. Conclusion Both Endoret‐Gel monotherapy and the combined treatment with PRGF were shown to promote facial rejuvenation and to palliate the age‐related cutaneous atrophy. The combined therapy may exert a synergistic effect that addresses both skin quality improvement and soft tissue restoration in a shorter period.

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Aging Skin as a Diagnostic Tool for Internal Diseases: A Chance for Dermatology

Cited by 2 publications

References 183 publications

Concentrated Growth Factors Can Inhibit Photoaging Damage Induced by Ultraviolet A (UVA) on the Human Dermal Fibroblasts In Vitro

Concentrated Growth Factors Can Inhibit Photoaging Damage Induced by Ultraviolet A (UVA) on the Human Dermal Fibroblasts In Vitro

Combined therapy with Endoret‐Gel and plasma rich in growth factors vs Endoret‐Gel alone in the management of facial rejuvenation: A comparative study

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