Aging, Resting Metabolic Rate, and Oxidative Damage: Results From the Louisiana Healthy Aging Study

Frisard, Madlyn I.; Broussard, A.C.; Davies, Sean S.; Roberts, L. Jackson; Rood, Jennifer; Jonge, Lilian de; Fang, Xiaobing; Jazwinski, S. Michal; Deutsch, Walter; Ravussin, Éric

doi:10.1093/gerona/62.7.752

Cited by 86 publications

(70 citation statements)

References 56 publications

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“…Essa situação já era esperada, pois, como demonstrado anteriormente, essa é uma tendência, uma vez que o organismo passa a gastar menor quantidade de energia com a idade. Entre as justificativas para esse declínio, estão: alterações na composição corporal que influenciam diretamente o GMR como redução da massa magra, redução da atividade física, alteração na função tireoidiana e menor atividade do sistema nervoso simpático (26).…”

Section: Discussionunclassified

Padronização do gasto metabólico de repouso e proposta de nova equação para uma população feminina brasileira

Rodrigues

Mancini

Dalcanale

et al. 2010

Arq Bras Endocrinol Metab

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RESUMOObjetivos: Os objetivos do estudo foram normatizar o gasto metabólico de repouso (GMR) de mulheres brasileiras, avaliar a adequação da fórmula de Harris Benedict (HB), a relação entre suas variáveis e propor novas equações para estimativa do GMR. InTRODUçãO I ndependentemente do fator básico desencadeador da obesidade, um desequilíbrio no balanço energético (BE), ou seja, entre a ingestão calórica total (IC) e o gasto energético total (GET), está intimamente relacionado à sua alta prevalência (1).O principal componente do GET é o gasto metabó-lico de repouso (GMR), o qual pode ser um preditor de ganho de peso (2-5).

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Section: Discussionunclassified

Padronização do gasto metabólico de repouso e proposta de nova equação para uma população feminina brasileira

Rodrigues

Mancini

Dalcanale

et al. 2010

Arq Bras Endocrinol Metab

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“…Impaired mitochondrial oxidation of fatty acids is commonly observed in elderly individuals (Solomon et al 2008), and therefore may induce an increase in cellular LCFA-CoA levels. Ageing is commonly associated with reductions in metabolic rate (Frisard et al 2007;Krems et al 2005;St-Onge and Gallagher 2010), and this perhaps may induce the reduced fatty acid oxidation, possibly inducing the increase in LCFA-CoA.…”

Section: Adiposity Phenotype Skeletal Muscle and Insulin Resistance mentioning

confidence: 99%

Ageing, adipose tissue, fatty acids and inflammation

2014

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A common feature of ageing is the alteration in tissue distribution and composition, with a shift in fat away from lower body and subcutaneous depots to visceral and ectopic sites. Redistribution of adipose tissue towards an ectopic site can have dramatic effects on metabolic function. In skeletal muscle, increased ectopic adiposity is linked to insulin resistance through lipid mediators such as ceramide or DAG, inhibiting the insulin receptor signalling pathway. Additionally, the risk of developing cardiovascular disease is increased with elevated visceral adipose distribution.In ageing, adipose tissue becomes dysfunctional, with the pathway of differentiation of preadipocytes to mature adipocytes becoming impaired; this results in dysfunctional adipocytes less able to store fat and subsequent fat redistribution to ectopic sites. Low grade systemic inflammation is commonly observed in ageing, and may drive the adipose tissue dysfunction, as proinflammatory cytokines are capable of inhibiting adipocyte differentiation. Beyond increased ectopic adiposity, the effect of impaired adipose tissue function is an elevation in systemic free fatty acids (FFA), a common feature of many metabolic disorders. Saturated fatty acids can be regarded as the most detrimental of FFA, being capable of inducing insulin resistance and inflammation through lipid mediators such as ceramide, which can increase risk of developing atherosclerosis. Elevated FFA, in particular saturated fatty acids, maybe a driving factor for both the increased insulin resistance, cardiovascular disease risk and inflammation in older adults.

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“…al. [20], an accumulation of oxidative damage with age therefore, oxidative stress might have minor influence. The increase in UC levels with age in our study may be due to smaller sample size and emphasizes the need for further studies on uric acid levels.…”

Section: Discussionmentioning

confidence: 99%

Role of Oxidative Stress on Age and Gender

Sailaja¹,

M²,

Rajendhra³

et al. 2015

IJIMS

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Background:Old age is an incurable disease which is more affected by the oxidative stress by damaging the DNA and disruptions in normal mechanisms of cellular signaling. There are dates which show possible role of oxidative stress and disturbance in antioxidant mechanisms in various disorders. Materials and Methods:A cross-sectional study was undertaken for a period of 12 months with clinically normal 109 subjects at the Narayana General Hospital, Nellore. Were divided into 6 groups (decade a group) and target for the level of Malondialdehyde (MDA) a lipid peroxidation product and marker of oxidative stress and protein carbonyls (PCO) levels reflects the protein oxidation process. Reduced Glutathione (GSH) is a representative of antioxidant potency of glutathione system in erythrocytes, and Uric acid (UC) for the antioxidative capacity.Result: Increased MDA, PCO, and uric acid levels. Decreased GSH levels were found. MDA and PCO significantly positively correlated. GSH significantly negatively correlated. UC was not associated with age. MDA, PCO, and GSH levels are independents of age. UC have significant gender difference. MDA and PCO were having strong negative correlation with GSH. MDA, PCO, and UC levels are significantly high in above 50 years compared to blow 50 years. GSH levels are significantly low in above 50 years compared to blow 50 years. Conclusion:Oxidative stress (MDA & PCO) increases with age and antioxidant activity (GSH) decreases with age. Uric acid (antioxidant) increases with age but gender difference is seen. Oxidative damage in the cell is accumulating with age and there is simultaneous decrease in the antioxidant capacity. Thus, Oxidative stress is considered as one of the causes for Aging and Age related diseases.

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Aging, Resting Metabolic Rate, and Oxidative Damage: Results From the Louisiana Healthy Aging Study

Cited by 86 publications

References 56 publications

Padronização do gasto metabólico de repouso e proposta de nova equação para uma população feminina brasileira

Padronização do gasto metabólico de repouso e proposta de nova equação para uma população feminina brasileira

Ageing, adipose tissue, fatty acids and inflammation

Role of Oxidative Stress on Age and Gender

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