Aging-related structural change in 3D extracellular matrix affects its mechanics

Park, Seungman; Kim, Byunggik

doi:10.1016/j.medengphy.2022.103843

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…Age is a major risk factor for numerous chronic conditions, including cancer, cardiovascular disease, neurodegenerative diseases (NDs), sarcopenia, osteoporosis, and kidney failure (Atella et al., 2019 ; Park, Jung, et al., 2020 ; Park & Kim, 2022 ; Sanchez et al., 2022 ). Damage to proteins and other biomolecules accumulates as people age, which results in biological deteriorations, such as genomic instability, mitochondrial dysfunction, or telomere attrition (López‐Otín et al., 2013 , 2023 ) in cells, tissues, and organelles.…”

Section: Introductionmentioning

confidence: 99%

Microphysiological systems for human aging research

Park,

Laskow,

Chen

et al. 2024

Aging Cell

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Recent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro. MPS therefore provide the potential to better understand human diseases and physiology. To date, numerous MPS platforms have been developed for various tissues and organs, including the heart, liver, kidney, blood vessels, muscle, and adipose tissue. However, only a few studies have explored using MPS platforms to unravel the effects of aging on human physiology and the pathogenesis of age‐related diseases. Age is one of the risk factors for many diseases, and enormous interest has been devoted to aging research. As such, a human MPS aging model could provide a more predictive tool to understand the molecular and cellular mechanisms underlying human aging and age‐related diseases. These models can also be used to evaluate preclinical drugs for age‐related diseases and translate them into clinical settings. Here, we provide a review on the application of MPS in aging research. First, we offer an overview of the molecular, cellular, and physiological changes with age in several tissues or organs. Next, we discuss previous aging models and the current state of MPS for studying human aging and age‐related conditions. Lastly, we address the limitations of current MPS and present future directions on the potential of MPS platforms for human aging research.

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Section: Introductionmentioning

confidence: 99%

Microphysiological systems for human aging research

Park,

Laskow,

Chen

et al. 2024

Aging Cell

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Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology

Pramotton,

Spitz,

Kamm

2024

Advanced Science

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Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing a significant global health challenge as well as a high socioeconomic burden. With aging constituting one of the main risk factors for some NDDs such as Alzheimer's disease (AD) and Parkinson's disease (PD), this societal toll is expected to rise considering the predicted increase in the aging population as well as the limited progress in the development of effective therapeutics. To address the high failure rates in clinical trials, legislative changes permitting the use of alternatives to traditional pre‐clinical in vivo models are implemented. In this regard, microphysiological systems (MPS) such as organ‐on‐a‐chip (OoC) platforms constitute a promising tool, due to their ability to mimic complex and human‐specific tissue niches in vitro. This review summarizes the current progress in modeling NDDs using OoC technology and discusses five critical aspects still insufficiently addressed in OoC models to date. Taking these aspects into consideration in the future MPS will advance the modeling of NDDs in vitro and increase their translational value in the clinical setting.

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