Aging-related severe hypertension induces detrusor underactivity in rats

Shimizu, Shogo; Nagao, Yoshiki; Kurabayashi, Atsushi; Shimizu, Takahiro; Higashi, Youichirou; Karashima, Takashi; Saito, Motoaki

doi:10.1016/j.lfs.2021.119855

Cited by 7 publications

(12 citation statements)

References 32 publications

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“…Voiding dysfunctions have been linked not only to diseases of the LUT, but also to systemic diseases such as diabetes [ 26 , 27 , 28 , 29 ], obesity [ 29 , 30 ], hyperlipidemia [ 31 , 32 ], and hypertension [ 33 , 34 , 35 ] or with metabolic syndrome that is defined by impaired glucose tolerance, central obesity, hypertension and dyslipidemia [ 36 , 37 , 38 ]. Metabolic syndrome and OAB may share common pathophysiology mechanisms [ 39 ] since patients with metabolic syndrome exhibit a higher incidence of OAB [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

et al. 2022

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Adenosine 5′-triphosphate (ATP) is released in the bladder lumen during filling. Urothelial ATP is presumed to regulate bladder excitability. Urinary ATP is suggested as a urinary biomarker of bladder dysfunctions since ATP is increased in the urine of patients with overactive bladder, interstitial cystitis or bladder pain syndrome. Altered urinary ATP might also be associated with voiding dysfunctions linked to disease states associated with metabolic syndrome. Extracellular ATP levels are determined by ATP release and ATP hydrolysis by membrane-bound and soluble nucleotidases (s-NTDs). It is currently unknown whether s-NTDs regulate urinary ATP. Using etheno-ATP substrate and HPLC-FLD detection techniques, we found that s-NTDs are released in the lumen of ex vivo mouse detrusor-free bladders. Capillary immunoelectrophoresis by ProteinSimple Wes determined that intraluminal solutions (ILS) collected at the end of filling contain ENTPD3 > ENPP1 > ENPP3 ≥ ENTPD2 = NT5E = ALPL/TNAP. Activation of adenylyl cyclase with forskolin increased luminal s-NTDs release whereas the AC inhibitor SQ22536 had no effect. In contrast, forskolin reduced and SQ22536 increased s-NTDs release in the lamina propria. Adenosine enhanced s-NTDs release and accelerated ATP hydrolysis in ILS and lamina propria. Therefore, there is a regulated release of s-NTDs in the bladder lumen during filling. Aberrant release or functions of urothelial s-NTDs might cause elevated urinary ATP in conditions with abnormal bladder excitability.

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Section: Introductionmentioning

confidence: 99%

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

et al. 2022

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“…In the present study, human omentin-1 had no influence on severe hypertension in aged SHR ( Figure 1 ). The SHR used in the present study were already at the ages (65–68-week-old) when their survival rate begins to decline [ 4 ]. On the other hand, since we could not exclude the possibility that human omentin-1 may suppress mild hypertension, we needed to examine whether the human omentin-1 administration prevents the development of hypertension in younger SHR.…”

Section: Discussionmentioning

confidence: 99%

“…Spontaneously hypertensive rats (SHR) whose systemic blood pressure increases with aging are frequently used animal models for investigating essential hypertension in humans [ 3 ]. Moreover, it was reported that the survival rate in SHR decreases after 54 weeks because of the severe damage found in several organs [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Human Omentin-1 Administration Ameliorates Hypertensive Complications without Affecting Hypertension in Spontaneously Hypertensive Rats

Okamura

Niijima

Kameshima

et al. 2023

IJMS

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Hypertension is one of the major risk factors for cardiovascular diseases and is caused by various abnormalities including the contractility of blood vessels. Spontaneously hypertensive rats (SHR), whose systemic blood pressure increases with aging, are a frequently used animal model for investigating essential hypertension and related complications in humans due to the damage of several organs. Human omentin-1 is an adipocytokine consisting of 313 amino acids. Serum omentin-1 levels decreased in hypertensive patients compared with normotensive controls. Furthermore, omentin-1 knockout mice showed elevated blood pressure and impaired endothelial vasodilation. Taken together, we hypothesized that adipocytokine, human omentin-1 may improve the hypertension and its complications including heart and renal failure in the aged SHR (65–68-weeks-old). SHR were subcutaneously administered with human omentin-1 (18 μg/kg/day, 2 weeks). Human omentin-1 had no effect on body weight, heart rate, and systolic blood pressure in SHR. The measurement of isometric contraction revealed that human omentin-1 had no influence on the enhanced vasocontractile or impaired vasodilator responses in the isolated thoracic aorta from SHR. On the other hand, human omentin-1 tended to improve left ventricular diastolic failure and renal failure in SHR. In summary, human omentin-1 tended to improve hypertensive complications (heart and renal failure), while it had no influence on the severe hypertension in the aged SHR. The further study of human omentin-1 may lead to the development of therapeutic agents for hypertensive complications.

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“…The trend of population aging is gradually increasing in developed countries and some developing countries, which means that the number of patients suffering from agingrelated diseases such as Alzheimer's disease (AD), hypertension, cardiopathy, cancer, and so on has increased sharply (Cylus & Al Tayara, 2021;Shimizu et al, 2021;Van der Lee et al, 2016;Wagner & Dimmeler, 2020;Z. Wang, Guo, et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The trend of population aging is gradually increasing in developed countries and some developing countries, which means that the number of patients suffering from aging‐related diseases such as Alzheimer's disease (AD), hypertension, cardiopathy, cancer, and so on has increased sharply (Cylus & Al Tayara, 2021; Shimizu et al, 2021; Van der Lee et al, 2016; Wagner & Dimmeler, 2020; Z. Wang, Guo, et al, 2021). Meanwhile, the proportion of young people suffering from lipid metabolism disorders represented by hyperlipidemia and obesity, type 2 diabetes, nonalcoholic fatty liver and other diseases is also rapidly increasing in recent years (Kahkoska et al, 2018; Simon et al, 2021; M. Sun et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

Xiao

et al. 2023

eFood

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At present, more and more people are suffering from various diseases and it is particularly important to find a suitable biological model to evaluate the prevention and treatment effects of various drugs and active ingredients on diseases. In all biological models, Caenorhabditis elegans is a kind of organism that is easy to observe and cultivate, has a clear genetic background and a high degree of signal pathway conservation with humans. A variety of active ingredients such as polyphenols, polysaccharides, polypeptides, and vitamins exist from natural products, which has extremely high physiological functions and medicinal values. It is highly reliable to evaluate the trophic and functional properties of the active ingredients from natural products in C. elegans. The functional properties of the active ingredients from natural products such as antiaging, anti-oxidation, regulating lipid metabolism, preventing and treating Alzheimer's disease in C. elegans were clarified in this review. At the same time, its possible pathways were summarized. The literature revealed that it had great effect to evaluate the nutrition and functionality of the active ingredients from natural products in C. elegans. Finally, the shortcomings in this field and suggestions for further improvement in this field have been emphasized.

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Aging-related severe hypertension induces detrusor underactivity in rats

Cited by 7 publications

References 32 publications

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

Urinary ATP Levels Are Controlled by Nucleotidases Released from the Urothelium in a Regulated Manner

Human Omentin-1 Administration Ameliorates Hypertensive Complications without Affecting Hypertension in Spontaneously Hypertensive Rats

Application of Caenorhabditis elegans in the evaluation of food nutrition: A review

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