Aging-related changes in auditory and visual integration measured with MEG

Stephen, Julia M.; Knoefel, Janice E.; Adair, John C.; Hart, Blaine L.; Aine, Cheryl J.

doi:10.1016/j.neulet.2010.08.023

Cited by 61 publications

(73 citation statements)

References 26 publications

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“…The group performed source localization using multi-dipole spatiotemporal modeling and detected larger amplitude modulations in the superior temporal cortex, the insula, parietal and cingulate regions to cross-modal presentations compared to unimodal ones in both young and older groups. However, the authors did not detect any evidence of age-related differences in multisensory responses (Stephen, Knoefel, Adair, Hart, & Aine, 2010).…”

Section: Multisensory Integrationmentioning

confidence: 78%

Visual dominance and multisensory integration changes with age

2013

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Objects comprise of visual and auditory signatures that arrive through distinct sensory channels. Exposure to cross-modal events sets up expectations about what a given object most likely "sounds" like, and vice versa, thereby facilitating detection and recognition. Whereas episodic and working memory functions decline with age, the extent to which multisensory integration processes change with age remains an open question. In the present study, we examined whether multisensory integration processes play a compensatory role in normal aging. Magnetoencephalography recordings of semantically-related cross-modal and unimodal auditory and visual stimuli captured the spatiotemporal dynamics of multisensory responses in young and older adults. Whereas sensory-specific regions showed increased activity in response to cross-modal compared to unimodal stimuli 100 ms after stimulus onset in both age groups, posterior parietal and medial prefrontal regions responded preferentially to cross-modal stimuli between 150 and 300 ms in the older group only. Additionally, faster detection of cross-modal stimuli correlated with increased activity in inferior parietal and medial prefrontal regions 100 ms after stimulus onset in older compared to younger adults. Age-related differences in visual dominance were also observed with older adults exhibiting significantly larger multisensory facilitation effects relative to the auditory modality. Using structural equation modeling, we showed that age-related increases in parietal and medial prefrontal source activity predicted faster detection of cross-modal stimuli. Furthermore, the relationship between performance and source activity was mediated by age-related reductions in gray matter volume in those regions. Thus, we propose that multisensory integration processes change with age such that posterior parietal and medial prefrontal activity underlies the integrated response in older adults. AbstractObjects comprise of visual and auditory signatures that arrive through distinct sensory channels. Exposure to cross-modal events sets up expectations about what a given object most likely "sounds" like, and vice versa, thereby facilitating detection and recognition. Whereas episodic and working memory functions decline with age, the extent to which multisensory integration processes change with age remains an open question. In the present study, we examined whether multisensory integration processes play a compensatory role in normal aging. Magnetoencephalography recordings of semantically-related cross-modal and unimodal auditory and visual stimuli captured the spatiotemporal dynamics of multisensory responses in young and older adults. Whereas sensory-specific regions showed increased activity in response to cross-modal compared to unimodal stimuli 100ms after stimulus onset in both age groups, posterior parietal and medial prefrontal regions responded preferentially to cross-modal stimuli between 150 and 300ms in the older group only. Additionally, faster detection of cross-moda...

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Section: Multisensory Integrationmentioning

confidence: 78%

Visual dominance and multisensory integration changes with age

2013

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“…Some authors used a simple unimodal or bimodal detection task (Townsend et al, 2006; Peiffer et al, 2007; Hugenschmidt et al, 2009a). Other authors investigated reaction times during unimodal or bimodal localization tasks (Hugenschmidt et al, 2009b; Campbell et al, 2010; Stephen et al, 2010; Dobreva et al, 2012; Wu et al, 2012) with spatial cueing (Guerreiro et al, 2012) or using peripheral vision (Cui et al, 2010; Dobreva et al, 2012) or the ability to remember or localize a stimulus in one modality while ignoring another modality (Diederich et al, 2008; Guerreiro et al, 2014, 2015). Other authors used judgment tasks; audiovisual temporal order judgment task (Setti et al, 2011b; de Boer-Schellekens and Vroomen, 2013; Fiacconi et al, 2013), audiovisual asynchrony judgment (Chan et al, 2014a) or audiovisual n -back task (Guerreiro and Van Gerven, 2011; Guerreiro et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Effects of Aging in Multisensory Integration: A Systematic Review

Dieuleveult

Siemonsma

Erp

et al. 2017

Front. Aging Neurosci.

143

149

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Multisensory integration (MSI) is the integration by the brain of environmental information acquired through more than one sense. Accurate MSI has been shown to be a key component of successful aging and to be crucial for processes underlying activities of daily living (ADLs). Problems in MSI could prevent older adults (OA) to age in place and live independently. However, there is a need to know how to assess changes in MSI in individuals. This systematic review provides an overview of tests assessing the effect of age on MSI in the healthy elderly population (aged 60 years and older). A literature search was done in Scopus. Articles from the earliest records available to January 20, 2016, were eligible for inclusion if assessing effects of aging on MSI in the healthy elderly population compared to younger adults (YA). These articles were rated for risk of bias with the Newcastle-Ottawa quality assessment. Out of 307 identified research articles, 49 articles were included for final review, describing 69 tests. The review indicated that OA maximize the use of multiple sources of information in comparison to YA (20 studies). In tasks that require more cognitive function, or when participants need to adapt rapidly to a situation, or when a dual task is added to the experiment, OA have problems selecting and integrating information properly as compared to YA (19 studies). Additionally, irrelevant or wrong information (i.e., distractors) has a greater impact on OA than on YA (21 studies). OA failing to weigh sensory information properly, has not been described in previous reviews. Anatomical changes (i.e., reduction of brain volume and differences of brain areas’ recruitment) and information processing changes (i.e., general cognitive slowing, inverse effectiveness, larger time window of integration, deficits in attentional control and increased noise at baseline) can only partly explain the differences between OA and YA regarding MSI. Since we have an interest in successful aging and early detection of MSI issues in the elderly population, the identified tests form a good starting point to develop a clinically useful toolkit to assess MSI in healthy OA.

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“…Hillis et al 2004) as for instance across the different types of receptors of the proprioceptive system (Mugge et al 2009). Since sensory weighting has shown to be less efficient in older adults as compared to young ones (Speers et al 2002;Stephen et al 2010), additional attentional resources may be required when the performance in a proprioceptive task has to be maintained in older adults. Finally, neurophysiological studies evidenced neurons, which have the characteristic of discharging both during the perception of an action and the production of the same action (Umiltà et al 2001).…”

Section: Effects Of Age On Proprioception In a Matching Single Taskmentioning

confidence: 99%

Presbypropria: the effects of physiological ageing on proprioceptive control

Boisgontier

Olivier

Chenu

et al. 2011

AGE

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Several changes in the human sensory systems, like presbycusis or presbyopia, are wellknown to occur with physiological ageing. A similar change is likely to occur in proprioception, too, but there are strong and unexplained discrepancies in the literature. It was proposed that assessment of the attentional cost of proprioceptive control could provide information able to unify these previous studies. To this aim, 15 young adults and 15 older adults performed a position matching task in single and dual-task paradigms with different difficulty levels of the secondary task (congruent and incongruent Stroop-type tasks) to assess presumed age-related deficits in proprioceptive control. Results showed that proprioceptive control was as accurate and as consistent in older as in young adults for a single proprioceptive task. However, performing a secondary cognitive task and increasing the difficulty of this secondary task evidenced both a decreased matching performance and/or an increased attentional cost of proprioceptive control in older adults as compared to young ones. These results advocated for an impaired proprioception in physiological ageing.

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Aging-related changes in auditory and visual integration measured with MEG

Cited by 61 publications

References 26 publications

Visual dominance and multisensory integration changes with age

Visual dominance and multisensory integration changes with age

Effects of Aging in Multisensory Integration: A Systematic Review

Presbypropria: the effects of physiological ageing on proprioceptive control

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