Aging redistributes medial prefrontal neuronal excitability and impedes extinction of trace fear conditioning

Kaczorowski, Catherine C.; Davis, Scott J.; Moyer, James R.

doi:10.1016/j.neurobiolaging.2011.03.020

Cited by 48 publications

(41 citation statements)

References 118 publications

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“…An increase of cortical excitability could account for the enhanced activation of the infralimbic cortex found in enriched animals. In fact, previous studies have suggested that an increased cortical excitability facilitates whereas a decreased cortical excitability reduces, cortical activation involved in fear memory [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Ronzoni

Antón

Mora

et al. 2016

Behavioural Brain Research

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2 HIGHLIGHTS-Infralimbic stimulation increases basal plasma levels of corticosterone.-Environmental enrichment enhances the effects of infralimbic stimulation.-Infralimbic inhibition reduces stress-induced corticosterone in control animals.-Infralimbic cortex contributes to HPA activation during stress and aversive memory. 3 ABSTRACTThe aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABA A antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone.These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories.

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Section: Discussionmentioning

confidence: 99%

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Ronzoni

Antón

Mora

et al. 2016

Behavioural Brain Research

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“…For example, young adult male college students are especially vulnerable to socially mediated delayed sleep potentially leading to delayed sleep phase syndrome in vulnerable individuals (Adan et al, 2012; Kudielka et al, 2006; Lehnkering and Siegmund, 2007). In addition, sleep physiology, circadian rhythms and their interactions with cognition change markedly with healthy aging (Pace-Schott and Spencer, 2011) and aging is associated with decreased aversive conditioning (Labar et al, 2004) and with decreased extinction in the rat (Kaczorowski et al, 2012). Extending these and other sleep-related findings to extinction learning and recall in the anxiety disorders constitutes the focus of our ongoing and future research.…”

Section: Discussionmentioning

confidence: 99%

Emotional trait and memory associates of sleep timing and quality

Pace‐Schott

Rubin

Tracy

et al. 2015

Psychiatry Research

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Poor ability to remember the extinction of conditioned fear, elevated trait anxiety, and delayed or disrupted nocturnal sleep are reported in anxiety disorders. The current study examines the interrelationship of these factors in healthy young-adult males. Skin- conductance response was conditioned to two differently colored lamps. One color but not the other was then extinguished. After varying delays, both colors were presented to determine extinction recall and generalization. Questionnaires measured sleep quality, morningness - eveningness, neuroticism and trait anxiety. A subset produced a mean 7.0 nights of actigraphy and sleep diaries. Median split of mean sleep midpoint defined early-and late-”sleep timers”. Extinction was more rapidly learned in the morning than evening only in early-timers, who also better generalized extinction recall. Extinction recall was greater with higher sleep efficiency. Sleep efficiency and morningness were negatively associated with neuroticism and anxiety. However, neuroticism and anxiety did not predict extinction learning, recall or generalization. Therefore, neuroticism/anxiety and deficient fear extinction, although both associated with poor quality and late timing of sleep, are not directly associated with each other. Elevated trait anxiety, in addition to predisposing directly to anxiety disorders, may thus also indirectly promote such disorders by impairing sleep and, consequently, extinction memory.

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“…Although rats did not receive an extinction session in the present study, our prior work suggests that extinction does not begin to emerge until at least three or more CS presentations (see Fig. S1 of Kaczorowski et al 2011a). Thus our use of two test trials did not obscure our ability to observe learning-related changes in CA1 excitability-we observed reduced AHPs in CA1 neurons from trace fear-conditioned but not pseudoconditioned rats.…”

Section: Acquisition Of Trace Fear Conditioning Is Correlated With Inmentioning

confidence: 91%

Trace fear conditioning enhances synaptic and intrinsic plasticity in rat hippocampus

Song

Detert

Sehgal

et al. 2012

Journal of Neurophysiology

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Experience-dependent synaptic and intrinsic plasticity are thought to be important substrates for learning-related changes in behavior. The present study combined trace fear conditioning with both extracellular and intracellular hippocampal recordings to study learning-related synaptic and intrinsic plasticity. Rats received one session of trace fear conditioning, followed by a brief conditioned stimulus (CS) test the next day. To relate behavioral performance with measures of hippocampal CA1 physiology, brain slices were prepared within 1 h of the CS test. In trace-conditioned rats, both synaptic plasticity and intrinsic excitability were significantly correlated with behavior such that better learning corresponded with enhanced long-term potentiation (LTP; r = 0.64, P < 0.05) and a smaller postburst afterhyperpolarization (AHP; r = -0.62, P < 0.05). Such correlations were not observed in pseudoconditioned rats, whose physiological data were comparable to those of poor learners and naive and chamber-exposed control rats. In addition, acquisition of trace fear conditioning did not enhance basal synaptic responses. Thus these data suggest that within the hippocampus both synaptic and intrinsic mechanisms are involved in the acquisition of trace fear conditioning.

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Aging redistributes medial prefrontal neuronal excitability and impedes extinction of trace fear conditioning

Cited by 48 publications

References 118 publications

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Infralimbic cortex controls the activity of the hypothalamus–pituitary–adrenal axis and the formation of aversive memory: Effects of environmental enrichment

Emotional trait and memory associates of sleep timing and quality

Trace fear conditioning enhances synaptic and intrinsic plasticity in rat hippocampus

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