Aging process, adherence to Mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells

Cesari, Francesca; Sofi, Francesco; Lova, Raffaele Molino; Vannetti, Federica; Pasquini, Guido; Cecchi, Francesca; Marcucci, Rossella; Gori, Anna Maria; Macchi, Claudio; Boni, Roberta; Castagnoli, Chiara; Frandi, Roberta; Pancani, Silvia; Paperini, Anita; Portaccio, Emilio; Razzolini, Lorenzo; Turcan, Nona; Valecchi, Debora; Gensini, Gian Franco; Abbate, Rosanna

doi:10.1016/j.numecd.2017.09.003

Cited by 39 publications

(31 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent years have therefore seen numerous studies analyzing the relationship and the mechanisms involved between the components of the Mediterranean diet and aging in both animals and humans [23]. The study conducted in the cohort of nonagenarians participating in the Mugello study suggests that daily consumption of olive oil, fruits, and vegetables can protect against the development of endothelial dysfunction through the increase of endothelial progenitor cells and circulating progenitor cells [24].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adherence to the Mediterranean Diet in Spanish Population and Its Relationship with Early Vascular Aging according to Sex and Age: EVA Study

et al. 2020

View full text Add to dashboard Cite

The objective of this study is to analyze the influence of adherence to the Mediterranean diet (MDA) and its components on early vascular aging (EVA) in a Spanish population sample free of cardiovascular disease and to analyze the differences by sex. Methods: We recruited 501 individuals aged 35–75 without cardiovascular disease by random sampling (55.90 ± 14.24 years, 49.70% men). EVA was defined in two steps: Step 1: subjects with vascular damage in carotid arteries or peripheral artery disease were classified as EVA. Step 2: subjects at the percentile of the combined Vascular Aging Index (VAI) were classified; ≥ p90 was considered EVA and < p90 was considered normal vascular aging (NVA), estimated using the following formula (VAI = (log (1.09) × 10 cIMT + log (1.14) cfPWV) × 39.1 + 4.76 by age and sex. Carotid-femoral pulse wave velocity (cfPWV) was measured by SphigmoCor System® and carotid intima-media thickness by Sonosite Micromax® ultrasound and classified thus: values ≥ Percentile 90 were considered EVA and those < Percentile 90 as NVA, with population percentiles analyzed. The principal result variable was assessed using the 14-item MEDAS questionnaire, developed and validated by the PREDIMED group, comprising 12 questions about the frequency of food consumption and two questions regarding the Spanish population’s typical eating habits. Results: MDA was observed by 25% (17% men and 34% women). EVA was present in 17% (29% men and 4% women). The adjusted logistic regression models showed that an increase in MDA decreases the probability of EVA in the global analysis (OR = 0.36; 95% CI: 0.16–0.82). In the analysis by sex, this association was only seen in men (OR = 0.33; 95% CI: 0.12–0.86), but not in women (OR = 0.31; 95% CI: 0.04–2.50). Conclusion: The results of this study suggest that a greater adherence to the Mediterranean diet decreases the probability of presenting EVA. In the analysis by sex, this association applies only to men.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Other studies support the hypothesis that the beneficial effects of consuming extra virgin olive oil on health may be mediated by its effects on mesenchymal stem cells. This may explain part of the health effects of olive oil consumption, such as preventing unwanted aging processes [24].…”

Section: Discussionmentioning

confidence: 99%

Adherence to the Mediterranean Diet in Spanish Population and Its Relationship with Early Vascular Aging according to Sex and Age: EVA Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Xia et al have shown altered CXCR4/JAK signaling in the elderly is linked to a reduced capacity for ECFC homing and re-endothelialization ( 29 ), which may concordantly induce anti-atherosclerotic EPC activity and up regulate expression of vascular endothelial growth factor (VEGF) receptors, as discussed elsewhere ( 35 ). Interestingly, Heiss et al found increased concentrations of VEGF in the blood of older individuals although ECFC responses to the protein were muted ( 32 , 36 , 37 ), thus implying an increased effort to mobilize ECFCs and effect vascular repair ( 32 ).…”

Section: Defective Epcs In Aging and Diabetesmentioning

confidence: 99%

Endothelial Progenitor Cells: New Targets for Therapeutics for Inflammatory Conditions With High Cardiovascular Risk

et al. 2018

View full text Add to dashboard Cite

Over the past decade, we have witnessed an exponential growth of interest into the role of endothelial progenitor cells (EPCs) in cardiovascular disease. While the major thinking revolves around EPC angiogenic repair properties, we have used a hypothesis-driven approach to discover disease-related defects in their characteristics and based on these findings, have identified opportunities for functional enhancement, which offer an exciting avenue for translation into clinical intervention. In this review, we focus on two groups; circulating myeloid angiogenic cells (MACs) and late outgrowth endothelial colony forming cells (ECFCs), and will discuss the unique properties and defects of each population, as new insights have been gained into the potential function of each sub-type using current techniques and multiomic technology. We will discuss their role in inflammatory disorders and alterations in mitochondrial function. In addition, we share key insights into the glycocalyx, and propose this network of membrane-bound proteoglycans and glycoproteins, covering the endothelium warrants further investigation in order to clarify its significance in ECFC regulation of vascularization and angiogenesis and ultimately for potential translational therapeutic aspects.

show abstract

“…This is a result of modifications in socio-environmental and biological factors during the human life course [2], with recent studies suggesting that some diets, economic status, the presence of a caregiver, are correlated with better aging [2][3][4][5][6]. Genetic signatures that predict the phenotypic outcome of exceptional long-living individuals are also identified [5,6].…”

Section: Introductionmentioning

confidence: 99%

Cognitive, functional, physical, and nutritional status of the oldest old encountered in primary care: a systematic review

et al. 2020

View full text Add to dashboard Cite

Background: The oldest old (individuals over 90 years) are a fast-growing population. Characterizing their specificity would be helpful to adapt health care. This study aimed to characterize the cognitive, functional, nutritional, and physical status of individuals over 90. Methods: We conducted a systematic review of cross-sectional or cohort studies of individuals aged 90 years old or more, living at home or in a nursing home, in April 2018. Two reviewers selected eligible articles, extracted data, and evaluated the risk of bias (assessed by the Newcastle-Ottawa Scale). Results: The search strategy identified 3086 references; 35 articles were included referring to 8 cross-sectional and 27 longitudinal studies. Dementia was diagnosed in 30-42.9% of study participants, cognitive impairment in 12-50%, and 31-65% had no cognitive impairment. In terms of activities of daily living, 14-72.6% of individuals had no difficulty, 35.6-38% had difficulty, and 14.4-55.5% were dependent. For instrumental activities of daily living, 20-67.9% needed help. Regarding nutritional status, the Mini Nutritional Assessment Short Form mean score ranged from 10.3 (SD: 1.8) to 11.1 (SD: 2.4). Eight to 32% of individuals could not stand up from a chair, 19-47% could stand without the use of their arms; and 12.9-15% were not able to walk 4 m. Conclusions: These results suggest a heterogeneous population with a certain proportion of oldest old with a low level of disability. These findings suggest that a specific approach in the care of the oldest old could help prevent disability.

show abstract

Aging process, adherence to Mediterranean diet and nutritional status in a large cohort of nonagenarians: Effects on endothelial progenitor cells

Cited by 39 publications

References 19 publications

Adherence to the Mediterranean Diet in Spanish Population and Its Relationship with Early Vascular Aging according to Sex and Age: EVA Study

Adherence to the Mediterranean Diet in Spanish Population and Its Relationship with Early Vascular Aging according to Sex and Age: EVA Study

Endothelial Progenitor Cells: New Targets for Therapeutics for Inflammatory Conditions With High Cardiovascular Risk

Cognitive, functional, physical, and nutritional status of the oldest old encountered in primary care: a systematic review

Contact Info

Product

Resources

About