Aging on a different scale – chronological versus pathology-related aging

Abstract

In the next decades the elderly population will increase dramatically, demanding appropriate solutions in health care and aging research focusing on healthy aging to prevent high burdens and costs in health care. For this, research targeting tissue-specific and individual aging is paramount to make the necessary progression in aging research. In a recently published study we have attempted to make a step interpreting aging data on chronological as well as pathological scale. For this, we sampled five major tissues at regular time intervals during the entire C57BL/6J murine lifespan from a controlled in vivo aging study, measured the whole transcriptome and incorporated temporal as well as physical health aspects into the analyses. In total, we used 18 different age-related pathological parameters and transcriptomic profiles of liver, kidney, spleen, lung and brain and created a database that can now be used for a broad systems biology approach. In our study, we focused on the dynamics of biological processes during chronological aging and the comparison between chronological and pathology-related aging.

Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance

“…At the start of the experiment young mice were used at the age of 8 to 10 weeks, old mice were used at the age of 62 to 72 weeks. The maximum life span of mice is more than the age within this range, but mice within this age range and even somewhat younger age have been show to express significant aging-related susceptibility to respiratory disease by influenza virus, RSV and SARS coronavirus 55 – 57 , declined immune responsiveness 55 , 58 and a broad range of other age-related aberrations 37 , 38 . We choose to use mice within this age range since they would show aging-related phenomena, without the risk of losing mice from our analyses due to very old age 37 , 38 .…”

Integrating functional ageing into daily clinical practice

“…Finally, altered intercellular communication and stem cell exhaustion are ultimately responsible for the functional decline associated with ageing 9 . However, the ageing rate varies substantially among individuals, even in genetically identical inbred animals 10 . These interconnected mechanisms of ageing, well identified in animal models, strongly suggest that in addition to genetics and time, other factors profoundly modify the ageing process 10 .…”

“…However, the ageing rate varies substantially among individuals, even in genetically identical inbred animals 10 . These interconnected mechanisms of ageing, well identified in animal models, strongly suggest that in addition to genetics and time, other factors profoundly modify the ageing process 10 .…”

Balanço dos receptores mineralocorticoides e glicocorticoides no giro denteado do hipocampo de cães idosos

“…Considerando o aumento da expectativa de vida canina (O'NEILL et al, 2013) e os processos neurodegenerativos associados ao envelhecimento (MELIS et al, 2013)…”

“…O processo de envelhecimento é acompanhado de uma deterioração da homeostase e função tecidual e varia entre diferentes indivíduos e órgãos (MELIS et al, 2013). O SNC é altamente vulnerável a este processo, devido a sua grande necessidade de oxigênio e a sua baixa capacidade antioxidante (DROR et al, 2014).…”