Aging of the hypothalamic-pituitary-adrenal axis in nonhuman primates with depression-like and aggressive behavior

Goncharova, N. D.; Marenin, Victor Yu.; Oganyan, T. É.

doi:10.18632/aging.100227

Cited by 25 publications

(28 citation statements)

References 59 publications

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“…Experiments on healthy non-human primates ( Macaca mulatta ) revealed that age-related dysfunctions of the HPA axis are associated with adaptive behavior of animals (Goncharova et al, 2010). Monkeys with depression-like behavior show age-related changes in the HPA axis function that are accompanied by maximal absolute and relative hypercortisolemia (high cortisol/DHEAS molar ratio) under resting conditions, as well as by a significantly greater increase in plasma cortisol levels with acute psycho-emotional stress.…”

Section: Avp In Regulation Of Hpa Axis Stress Responsiveness During Amentioning

confidence: 99%

Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation

Goncharova¹

2013

Front. Endocrinol.

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The hypothalamic–pituitary–adrenal (HPA) axis plays a key role in adaptation to environmental stresses. Parvicellular neurons of the hypothalamic paraventricular nucleus secrete corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) into pituitary portal system; CRH and AVP stimulate adrenocorticotropic hormone (ACTH) release through specific G-protein-coupled membrane receptors on pituitary corticotrophs, CRHR1 for CRH and V1b for AVP; the adrenal gland cortex secretes glucocorticoids in response to ACTH. The glucocorticoids activate specific receptors in brain and peripheral tissues thereby triggering the necessary metabolic, immune, neuromodulatory, and behavioral changes to resist stress. While importance of CRH, as a key hypothalamic factor of HPA axis regulation in basal and stress conditions in most species, is generally recognized, role of AVP remains to be clarified. This review focuses on the role of AVP in the regulation of stress responsiveness of the HPA axis with emphasis on the effects of aging on vasopressinergic regulation of HPA axis stress responsiveness. Under most of the known stressors, AVP is necessary for acute ACTH secretion but in a context-specific manner. The current data on the AVP role in regulation of HPA responsiveness to chronic stress in adulthood are rather contradictory. The importance of the vasopressinergic regulation of the HPA stress responsiveness is greatest during fetal development, in neonatal period, and in the lactating adult. Aging associated with increased variability in several parameters of HPA function including basal state, responsiveness to stressors, and special testing. Reports on the possible role of the AVP/V1b receptor system in the increase of HPA axis hyperactivity with aging are contradictory and requires further research. Many contradictory results may be due to age and species differences in the HPA function of rodents and primates.

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Section: Avp In Regulation Of Hpa Axis Stress Responsiveness During Amentioning

confidence: 99%

Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation

Goncharova¹

2013

Front. Endocrinol.

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“…Some studies have revealed that DHEA and DHEAS increased memory [Flood & Roberts, ; Vallee et al, ] and enhanced the immune system [Khorram et al, ]. Increases in serum DHEAS concentrations have been observed in stressed rhesus monkeys ( Macaca mulatta ) [Goncharova et al, ; Maninger et al, ], and elevated serum DHEAS levels have been found in aggressive rhesus monkeys [Goncharova et al, ]. The relationship between DHEAS and cortisol has been used as an index to measure stress [Goodyer et al, ].…”

Section: Introductionmentioning

confidence: 99%

Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)

Takeshita

Bercovitch

Huffman

et al. 2014

American J Primatol

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The ability to determine hormonal profiles of primate populations using non-invasive techniques can help to monitor physical fitness, stress, and physiological responses to environmental changes. We investigated fecal glucocorticoids (fGC) and DHEAS concentrations in captive Japanese macaques (Macaca fuscata) in relation to environmental, biological, and social factors. The subjects were female Japanese monkeys from 4 months to 31 years old housed in captivity (27 in social groups and 12 in single cages). Fecal samples were collected from all females, and behavioral data from the social groups during the mating season and the following birth season. Hormonal concentrations were analyzed by enzyme immunoassay. Our results revealed that both fGC and fecal DHEAS concentrations are higher in females housed indoors in single cages than in those living outdoors in social groups. We also found that fGC concentrations were higher in the cycling females during the mating (winter) season than the lactating females in the birth (spring) season. Age was negatively associated to both fGC and fecal DHEAS levels, but the relationship between age and fecal DHEAS was more evident in females housed indoors in single cages than in females housed in outdoor social groups. We did not observe any association of dominance rank with either fecal DHEAS or fGC. This study showed that measurement of fecal DHEAS and fGC can be a good method to assess stress in Japanese macaques. These findings provide insights about the physiology of these two adrenal hormones in female Japanese macaques, which can be applied to wild populations and is fundamental for captive management and conservation biology.

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“…However, two females exhibited excessively anxious behavior, associated with high motor activity during preparation to blood collection, which did not cease by the end of the adaptation period and persisted over the entire experiment. The criteria by which the animals were referred to standard and depressive psychophysiological types were determined previously [1,6,8]. Hormonal parameters of animals with depression-like behavior and with excessive anxiety were similar and hence, we united them in groups with anxious and depressive behavior (ADB).…”

Section: Methodsmentioning

confidence: 99%

“…The degree of these age-specifi c differences sometimes varies. Previously we have detected a relationship between the age-specifi c changes in HPAS work, including its reaction to an acute stress, and the psychophysiological types of animals [1,6,8]. It is therefore just natural to expect that the appurtenance to a certain psychophysiological type largely determine the degree of age-specifi c differences in…”

mentioning

confidence: 99%

Age-Specific and Individual Features of Vasopressinergic Regulation of the Hypothalamic–Pituitary–Adrenal System in Primates

et al. 2015

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Experimental study was carried out on young mature (6-8 years) and old (21-27 years) rhesus macaques with anxious and depression-like behavior and with standard (control) adaptive behavior. The responce of the adenohypophysis to arginine vasopressin depended on age and the type of adaptive behavior. Young animals with standard behavior demonstrated much higher concentrations of ACTH in the peripheral plasma in response to arginine vasopressin than old animals. The secretion of ACTH was higher in young and old animals with anxious and depressive-like adaptive behavior and they exhibited no age-specific differences in reaction to arginine vasopressin, which were observed in control animals. Preinjection of vasopressin V1b receptor antagonist to a female with high anxiety sharply reduced ACTH secretion in response to insulin-induced hypoglycemia in comparison with ACTH secretion under the same conditions without antagonist injection. These results suggested that the vasopressinergic system of animals with anxious and depressive behavior plays an important role in the regulation of ACTH secretion and in activity of the hypothalamic-pituitary-adrenal system in general.

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Aging of the hypothalamic-pituitary-adrenal axis in nonhuman primates with depression-like and aggressive behavior

Cited by 25 publications

References 59 publications

Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation

Stress Responsiveness of the Hypothalamic–Pituitary–Adrenal Axis: Age-Related Features of the Vasopressinergic Regulation

Environmental, biological, and social factors influencing fecal adrenal steroid concentrations in female Japanese macaques (Macaca fuscata)

Age-Specific and Individual Features of Vasopressinergic Regulation of the Hypothalamic–Pituitary–Adrenal System in Primates

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