Aging of human alpha rhythm

Knyazeva, Maria G.; Barzegaran, Elham; Vildavski, Vladimir Y.; Demonet, Jean-François

doi:10.1016/j.neurobiolaging.2018.05.018

Cited by 72 publications

(70 citation statements)

References 86 publications

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“…In the epoch-based approach, the delta band shows higher frequency in young adults and theta band showing lower frequency in young adults. These observations are in part consistent with findings by Knyazeva et al, whereby low-frequency oscillations originating from the occipito-temporal regions in young adults move anteriorly with age (Knyazeva et al, 2018). In both epoch-based and non-epoch approaches, the beta band shows the strongest age effects (higher in older adults) in the cingulate and precuneus areas, which are generally associated with the default-mode network.…”

Section: The Effect Of Age On Eeg Frequencysupporting

confidence: 91%

“…Moreover, regions showing beta frequency increases appear to not overlap at all with regions showing beta power increase in aging. Chiang et al reported frontal-occipital alpha frequency differences (lower alpha frequency in frontal lobe) that may be altered by aging (Chiang et al, 2011), which, as Knyazeva et al described, amounts to a merging of high-and low-frequency alpha peaks in aging (Knyazeva et al, 2018). However, this did not translate into a frequency shift for alpha.…”

Section: The Effect Of Age On Eeg Frequencymentioning

confidence: 98%

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Variations in the frequency and amplitude of resting-state EEG and fMRI signals in normal adults: The effects of age and sex

Zhong

Chen

2020

Preprint

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Frequency and amplitude features of both resting-state electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) are crucial metrics that reveal patterns of brain health in aging. However, the association between these two modalities is still unclear. In this study, we examined the peak frequency and standard deviation of both modalities in a dataset comprising healthy young (35.5±3.4 years, N=134) and healthy old (66.9±4.8 years, N=51) adults. Both age and sex effects were examined using non-parametric analyses of variance (ANOVA) and Tukey’s Honest Significant Difference (HSD) post-hoc comparisons in the cortical and subcortical regions. We found that, with age, EEG power decreases in the low frequency band (1-12 Hz) but increases in the high frequency band (12-30 Hz). Moreover, EEG frequency generally shifts up with aging. For fMRI, fluctuation amplitude is lower but fluctuation frequency is higher in older adults, but in a manner that depends on the fMRI frequency range. Furthermore, there are significant sex effects in EEG power (female > male), but the sex effect is negligible for EEG frequency as well as fMRI power and frequency. We also found that the fMRI-EEG power ratio is higher in young adults than old adults. However, the mediation analysis shows the association between EEG and fMRI parameters in aging is negligible. This is the first study that examines both power and frequency of both resting EEG and fMRI signals in the same cohort. In conclusion, both fMRI and EEG signals reflect age-related and sex-related brain differences, but they likely associate with different origins.

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Section: The Effect Of Age On Eeg Frequencysupporting

confidence: 91%

Section: The Effect Of Age On Eeg Frequencymentioning

confidence: 98%

Variations in the frequency and amplitude of resting-state EEG and fMRI signals in normal adults: The effects of age and sex

Zhong

Chen

2020

Preprint

View full text Add to dashboard Cite

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“…Aging also affects alpha oscillatory activity in other brain regions. With regard to the posterior alpha rhythm (8-13 Hz), there was a marked reduction in amplitude, slowing of spontaneous oscillation, and declined reactivity (eye-opening) which correlated with global cognitive performance in the elderly (Babiloni et al, 2006;Ishii et al, 2017;Knyazeva et al, 2018). Older adults also showed reduced connectivity in the upper alpha band compared to young adults (Kikuchi et al, 2000;Vysata et al, 2014;Scally et al, 2018).…”

Section: Introductionmentioning

confidence: 94%

Age-Dependent Effect of Transcranial Alternating Current Stimulation on Motor Skill Consolidation

Fresnoza

Christova

Bieler

et al. 2020

Front. Aging Neurosci.

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Transcranial alternating current stimulation (tACS) is the application of subthreshold, sinusoidal current to modulate ongoing brain rhythms related to sensory, motor and cognitive processes. Electrophysiological studies suggested that the effect of tACS applied at an alpha frequency (8-12 Hz) was state-dependent. The effects of tACS, that is, an increase in parieto-occipital electroencephalography (EEG) alpha power and magnetoencephalography (MEG) phase coherence, was only observed when the eyes were open (low alpha power) and not when the eyes were closed (high alpha power). This state-dependency of the effects of alpha tACS might extend to the aging brain characterized by general slowing and decrease in spectral power of the alpha rhythm. We additionally hypothesized that tACS will influence the motor cortex, which is involved in motor skill learning and consolidation. A group of young and old healthy adults performed a serial reaction time task (SRTT) with their right hand before and after the tACS stimulation. Each participant underwent three sessions of stimulation: sham, stimulation applied at the individual participant's alpha peak frequency or individual alpha peak frequency (iAPF; α-tACS) and stimulation with iAPF plus 2 Hz (α2-tACS) to the left motor cortex for 10 min (1.5 mA). We measured the effect of stimulation on general motor skill (GMS) and sequence-specific skill (SS) consolidation. We found that α-tACS and α2-tACS improved GMS and SS consolidation in the old group. In contrast, α-tACS minimally improved GMS consolidation but impaired SS consolidation in the young group. On the other hand, α2-tACS was detrimental to the consolidation of both skills in the young group. Our results suggest that individuals with aberrant alpha rhythm such as the elderly could benefit more from tACS stimulation, whereas for young healthy individuals with intact alpha rhythm the stimulation could be detrimental.

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“…PARAFAC provides a unique solution to decompose the EEG signal to three factors (time, frequency, channel; Figure 3A) and may enhance sensitivity. It was previously applied to electrophysiological recordings (Miwakeichi et al, 2004;Yanagawa et al, 2013;Meij et al, 2016), and specifically for assessing individual alpha oscillations (Barzegaran et al, 2017;Knyazeva et al, 2018); for a detailed review of its EEG applications, see Cong et al (2015). We identified the regions and frequencies of interest for alpha oscillations in each participant separately using unbiased "break" data between stimulation blocks ( Figure 3B).…”

Section: Transcutaneous Vagus Nerve Stimulation Attenuates Alpha Oscimentioning

confidence: 99%

Transcutaneous vagus nerve stimulation in humans induces pupil dilation and attenuates alpha oscillations

Sharon

Fahoum

Nir

2020

Preprint

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Vagus nerve stimulation (VNS) is widely used to treat drug-resistant epilepsy and depression. While the precise mechanisms mediating its long-term therapeutic effects are not fully resolved, they likely involve Locus Coeruleus (LC) stimulation via the nucleus of the solitary tract (NTS) that receives afferent vagal inputs. In rats, VNS elevates LC firing and forebrain noradrenaline (NE) levels, whereas LC lesions suppress VNS therapeutic efficacy. Non-invasive transcutaneous VNS (tVNS) employs electrical stimulation targeting the auricular branch of the vagus nerve at the Cymba Conchae of the ear, but it remains unclear to what extent tVNS mimics VNS. Here, we investigated the short-term effects of tVNS in healthy human male volunteers (n=24) using high-density EEG and pupillometry during visual fixation at rest, comparing short (3.4s) trials of tVNS to sham electrical stimulation at the earlobe (far from the vagus nerve branch) to control for somatosensory stimulation. Although tVNS and sham stimulation did not differ in subjective intensity ratings, tVNS led to robust pupil dilation (peaking 4-5s after trial onset) that was significantly higher than following sham stimulation. We further quantified how tVNS modulates idle occipital alpha (8-13Hz) activity, identified in each participant using parallel factor analysis. We found that tVNS attenuates alpha oscillations to a greater extent than does sham stimulation. Thus, tVNS reliably induces pupillary and EEG markers of arousal beyond the effects of somatosensory stimulation, supporting the hypothesis that it elevates noradrenaline and acetylcholine signaling and mimics invasive VNS.

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Aging of human alpha rhythm

Cited by 72 publications

References 86 publications

Variations in the frequency and amplitude of resting-state EEG and fMRI signals in normal adults: The effects of age and sex

Variations in the frequency and amplitude of resting-state EEG and fMRI signals in normal adults: The effects of age and sex

Age-Dependent Effect of Transcranial Alternating Current Stimulation on Motor Skill Consolidation

Transcutaneous vagus nerve stimulation in humans induces pupil dilation and attenuates alpha oscillations

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