Aging of Connective Tissue and Molecular Transport

Sobel, Harold J.

doi:10.1159/000211663

Cited by 13 publications

(3 citation statements)

References 49 publications

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“…However, the erythro cytes were contaminated with plasma and yielded high values for sodium. There is some meagre evidence [reviewed by Sobel, 1968] that diffusion of large molecules through connective tissue decreases with age, but that of small molecules increases, which would be in keeping with the present results on erythrocytes.…”

Section: Discussionsupporting

confidence: 92%

The Relationship between Age and Sodium Metabolism in Human Erythrocytes

Naylor¹

1970

Gerontology

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Section: Discussionsupporting

confidence: 92%

The Relationship between Age and Sodium Metabolism in Human Erythrocytes

Naylor¹

1970

Gerontology

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“…Visualization of collagen fibers may allow for a better assessment of the density of the connective tissue surrounding endometrial glands. Increased density can be responsible for the impaired transport of nutrients and endocrine signaling molecules from blood vessels to the glandular epithelium; thus, it may cause degeneration and loss of function [ 83 , 84 ]. The specific staining methods offer superior contrast between collagen fibers and glands.…”

Section: Measurement and Influence Of Fibrotic Processesmentioning

confidence: 99%

Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options

Zdrojkowski,

Pawliński,

Skierbiszewska

et al. 2024

Animals

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Uterine diseases stand as the primary cause of infertility in mares; however, the diagnostic process often relies on obtaining endometrial biopsies and their hematoxylin–eosin staining. This review seeks to present the variability of uterine changes and their impact on fertility and underscore the utility of special stains, such as Masson trichrome, picrosirius red, elastica van Gieson, or periodic acid–Schiff, in enhancing diagnostic breadth. Connective tissue evaluation in the cervix is discussed, as it is subjected to cyclic changes and the impact on overall fertility. Vascular changes, particularly prevalent in multiparous mares, play a crucial role in adapting to physiological and pathological alterations, affecting early gestation and impeding placental development. Given that uterine vascular pathologies often involve fibrotic changes, connective tissue stains emerge as a valuable tool in this context. Moreover, equine endometriosis, predominantly associated with endometrial fibrosis, further highlights the relevance of special stains, suggesting their underutilization in the diagnostic process. Recognizing the subjective nature of diagnosing uterine pathologies and the need for additional diagnostic tools, we advocate for using dedicated stains in the histopathological evaluation of uterine samples. In conclusion, we encourage scientists and diagnosticians to embrace additional tools that enhance pathology visualization, enabling more reliable diagnoses concerning expected fertility.

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“…Aside from changes in the nervous system there are general modifications in cells which have been considered as the biological substrate of the cognitive changes we see. The issue of molecular transport of nutrients involves cell and membrane changes, connective tissue alterations (in collagen, elastin, and ground substance), and circulatory functioning (Sobel, 1968). Sobel referred to McFarland's position that lack of oxygen by whatever mechanism is a key element of biological functioning that may prevent effective psychological as well as metabolic performance.…”

Section: Speed Of Behavior and Biological Changesmentioning

confidence: 99%

A biobehavioral approach to intellectual changes with aging.

Jarvik¹,

Cohén²

1973

The Psychology of Adult Development and Aging.

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However elegant and memorable, brevity can never, in the nature of things, do justice to all the facts of a complex situation. On such a theme one can be brief only by omission and simplification. Omission and simplification help us to understand-but help us, in many cases, to understand the wrong thing, for our comprehension may be only of the abbreviator's neatly formulated notions, not of the vast, ramifying reality from which these notions have been so arbitrarily abstracted.But life is short and information endless; nobody has time for everything. In practice we are generally forced to choose between an unduly brief exposition and no exposition at all. Abbreviation is a necsary evil and the abbreviator's business is to make the best of a job, which, though intrinsically bad, is still better than nothing. He must learn to simplify, but not to the point of falsification. He must learn to concentrate upon the essentials of a situation, but without ignoring too many of reality's qualifying side-issues.Aldous HuxleyWe are indebted to Corsellis (1962) for leading us to a lucid expression of our thoughts in tackling an overview of a virgin territory -the psychobiology of age-correlated intellectual changes. The most clearly observable, and perhaps most salient manifestation of the psychobiological changes that occur with advancing age is the gradual enfeeblement of mind and body. This enfeeblement L k y F. Jarvik received her PhD in psychology from Columbia University in 1950 and her MD from Western Reserve University in 1954. She

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Aging of Connective Tissue and Molecular Transport

Cited by 13 publications

References 49 publications

The Relationship between Age and Sodium Metabolism in Human Erythrocytes

The Relationship between Age and Sodium Metabolism in Human Erythrocytes

Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options

A biobehavioral approach to intellectual changes with aging.

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