Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF

Frasca, Daniela; Riley, Richard L.; Blomberg, Bonnie B.

doi:10.1016/j.exger.2006.09.003

Cited by 41 publications

(25 citation statements)

References 56 publications

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“…In vitro secreted IgG is reduced with age in both mice (Frasca et al 2007b) and humans (Frasca et al 2008). However, in vivo, despite the reduced number of B cells with age and the defects in class-switching, serum IgG, IgA (but not IgM) are increased with age (Paganelli et al 1992).…”

Section: Consequences Of Senescence On B Cell Functionmentioning

confidence: 94%

The ageing B cell population: Composition and function

2009

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Age-related changes in the structure and function of the immune system, collectively termed immunosenescence, result in poor responses to infections, increased susceptibility to cancers and increased incidence of autoimmune diseases. The humoral immune response, maintained by the B cell compartment, has a key role in an effective immune system-not only in producing high affinity antibodies that are crucial for vaccination strategies, but in assisting other components of the immune system in their function. Hence an understanding of B cell immunosenescence in particular is vital in designing strategies to combat the effects of age on immune function. Numerous studies have been undertaken using small animal models in order to understand immunosenescence, and these have contributed greatly to our understanding of the events that underpin impaired immune responses. However, there are key differences between the human and the mouse and a clear understanding of these differences is required when extrapolating from one species to the other. In this article we present an overview of B cell development and summarise current data on age-related B cell changes, at both the population level and at the individual mechanistic level. Areas of similarity and difference between human and mouse models are highlighted.

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Section: Consequences Of Senescence On B Cell Functionmentioning

confidence: 94%

The ageing B cell population: Composition and function

2009

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“…It has also been shown to be the key transcription factor in mouse or human B cells undergoing CSR in response to BAFF, the B cell-activating factor, also called BLyS, TALL-1, THANK, ZTNF4, or TNF13B (79 -81). We have recently investigated the ability of BAFF/IL-4, as compared with anti-CD40/IL-4, to induce CSR to ␥ 1 in splenic B cells from young and old mice (82). We found that NF-B is not involved in the decreased response of old B cells to anti-CD40/IL-4.…”

Section: Molecular Mechanisms For the Reduced Activity Of B Cells In mentioning

confidence: 94%

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

Frasca

Landin

Riley

et al. 2008

The Journal of Immunology

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The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.

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“…Concerning the effects of ageing on the number of immunoglobulin-producing cells in the bone marrow, Speziali et al (2009) have shown that IgG, IgM and IgA immunoglobulin-producing cells were increased in aged mice and these results are coherent with the levels of serum immunoglobulins found, except for IgM that were unaltered in old mice. Frasca et al (2004Frasca et al ( , 2007, have shown that in vitro stimulated splenic B cells from senescent mice are deficient in the production of multiple class switch isotypes and that deficiency is correlated with decreased induction of transcription factor E47, poor activation-induced cytidine deaminase (AID) expression and consequent down-regulation of class switch recombination. As others (Speziali et al, 2009) have reported increased levels of postswitch immunoglobulin isotypes as well as a rise in the number of IgA-and IgG-producing cells in aged mice, it could be speculate that this augment may be due to the proliferation of memory B cells, rather than activation of naïve cells.…”

Section: B Lymphocytesmentioning

confidence: 99%

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati¹,

Buffa²,

Candore³

et al. 2011

Ageing Research Reviews

101

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a b s t r a c tImmunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG + IgD − CD27 − ) that we have demonstrated is increased in healthy elderly.

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Aging murine B cells have decreased class switch induced by anti-CD40 or BAFF

Cited by 41 publications

References 56 publications

The ageing B cell population: Composition and function

The ageing B cell population: Composition and function

Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

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