Aging, mortality and the fast growth trade-off of<i>Schizosaccharomyces pombe</i>

Nakaoka, Hidenori; Wakamoto, Yuichi

doi:10.1101/128298

Cited by 4 publications

(4 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The trade-off between the growth rate and death rate are well reported in a variety of conditions [14][15][16][17][18][19], and the trade-offs between the growth and death rate are linear in some cases [12,13,20]. With the linear trade-off, the evolution could not find an optimal point in the present model and the whole population faced extinction.…”

Section: Discussionmentioning

confidence: 72%

“…Interestingly, it is well reported that there are trade-offs between the growth rate and the resistance to environmental stresses: the trade-off relationship between the growth rate and the tolerance (or resistance) to antibiotics [12,13], osmotic and oxidative [14][15][16][17], detergent [18], and nickel [19] stresses. Moreover, it is recently reported that the growth rate and the death rate have a positive linear correlation even under unstressed condition in the fission yeast [20]. These observations indicate that it is unlikely for a bacterial species to evolve to be able to grow very fast in the feast period and be significantly tolerant to the long famine period at the same time.…”

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Dynamics of bacterial populations under the feast-famine cycles

Himeoka

Mitarai

2020

Phys. Rev. Research

View full text Add to dashboard Cite

Bacterial populations in natural conditions are expected to experience stochastic environmental fluctuations, and in addition, environments are affected by bacterial activities since they consume substrates and excrete various chemicals. One of the likely environment fluctuations happens in nature is the repeated cycle of substrate-rich conditions and starvation, called "feast-famine cycle". It is not trivial how bacteria can cope with the feast-famine cycle and evolve under such situation, since in the feast period faster growth is beneficial in competition, but faster growth will shorten the feast period. Furthermore, in the famine period the tolerance to the starvation is needed, which may be negatively correlate with the faster growth. We here study possible outcomes of population dynamics and evolution under the feast-famine cycle by a simple stochastic model. In the model, the feast (substrate-rich) period is led by a stochastic substrate addition event, while the famine (starvation) period is evoked because bacteria use the supplied substrate. By allowing the model bacteria to evolve growth rate in the feast period with a trade-off with the death rate in the famine period, the bacterial population tends to increase the growth rate and the death rate, even though that tends to decrease the total population size. Under a certain condition, bacterial population eventually go extinct as evolutionary consequence. * yusuke.himeoka@nbi.ku.dk and mitarai@nbi.ku.dk

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Introductionmentioning

confidence: 96%

Dynamics of bacterial populations under the feast-famine cycles

Himeoka

Mitarai

2020

Phys. Rev. Research

View full text Add to dashboard Cite

show abstract

“…We continuously image the old-pole cell with fluorescence microscopy for up to 60hrs ( Figure 3A). We note that unlike Saccharomyces cerevisiae, S. pombe does not execute an aging program but rather dies stochastically (Coelho et al, 2013;Nakaoka and Wakamoto, 2017;Spivey et al, 2017). Thus, imaging S. pombe over long timescales avoids the confounding effects of aging on epigenetic behavior (Guarente, 2000;Li et al, 2017).…”

Section: Rnai-and Atf1/pcr1 Nucleate Two Types Of Spreading Reactionsmentioning

confidence: 98%

“…However, even in mammalian systems that feature DNA methylation, intergenerational stability of heterochromatin spreading requires continuous presence of the non-enzymatic subunits of the spreading enzyme complex, including, for example, methyl histone reader proteins (Tchasovnikarova et al, 2015). Further, loci repressed by spreading are vulnerable to euchromatin invasion (Narendra et al, 2015). This implies that, even in mammalian systems, spreading is not intrinsically self-sustaining once initially triggered.…”

Section: Implications For the Maintenance Of Heterochromatin Spreadingmentioning

confidence: 99%

A memory element imposes epigenetic behavior on intrinsically labile RNAi-induced heterochromatin spread

Greenstein

Jones

Spivey

et al. 2017

Preprint

View full text Add to dashboard Cite

ABTRACTThe heterochromatin spreading reaction is a central contributor to the formation of gene-repressive structures, which are re-established with high fidelity following replication. The high fidelity of this process is not obviously encoded in the primary spreading reaction. To resolve origins of stable inheritance of repression, we probed the intrinsic fidelity of spreading events in fission yeast using a system that quantitatively describes the spreading reaction in live single cells. We show that spreading from RNAi-nucleated elements is stochastic, multimodal, and fluctuates dynamically across time. In contrast, a second form of spreading, nucleated by the cis-acting element REIII, is deterministic, has high memory capacity and acts as the source of locus fidelity. REIII enables fidelity in part by endowing the locus with resistance to perturbations. Together, our results suggest that epigenetic capacity may not be intrinsically encoded in the spreading reaction, but rather requires collaboration with specialized memory elements.This movie consists of imaging in 4 channels, listed from top to bottom: Bright field, "green", "orange", and "red" for cell #407 from the strain PAS391 ΔREIII HSS . X-Y fluorescence plot for this cell is shown in Figure 3D. SVideo 5: Cell #123 from strain PAS387This movie consists of imaging in 4 channels, listed from top to bottom: Bright field, "green", "orange", and "red" for cell #123 from the strain PAS387 ΔK HSS . X-Y fluorescence plot for this cell is shown in Figure 3E.

show abstract

Dissecting of the AI-2/LuxS Mediated Growth Characteristics and Bacteriostatic Ability of Lactiplantibacillus plantarum SS-128 by Integration of Transcriptomics and Metabolomics

Qian

et al. 2022

Foods

View full text Add to dashboard Cite

Lactiplantibacillus plantarum could regulate certain physiological functions through the AI-2/LuxS-mediated quorum sensing (QS) system. To explore the regulation mechanism on the growth characteristics and bacteriostatic ability of L. plantarum SS-128, a luxS mutant was constructed by a two-step homologous recombination. Compared with ΔluxS/SS-128, the metabolites of SS-128 had stronger bacteriostatic ability. The combined analysis of transcriptomics and metabolomics data showed that SS-128 exhibited higher pyruvate metabolic efficiency and energy input, followed by higher LDH level and metabolite overflow compared to ΔluxS/SS-128, resulting in stronger bacteriostatic ability. The absence of luxS induces a regulatory pathway that burdens the cysteine cycle by quantitatively drawing off central metabolic intermediaries. To accommodate this mutations, ΔluxS/SS-128 exhibited lower metabolite overflow and abnormal proliferation. These results demonstrate that the growth characteristic and metabolism of L. plantarum SS-128 are mediated by the AI-2/LuxS QS system, which is a positive regulator involved in food safety. It would be helpful to investigate more bio-preservation control potential of L. plantarum, especially when applied in food industrial biotechnology.

show abstract

Aging, mortality and the fast growth trade-off ofSchizosaccharomyces pombe

Cited by 4 publications

References 76 publications

Dynamics of bacterial populations under the feast-famine cycles

Dynamics of bacterial populations under the feast-famine cycles

A memory element imposes epigenetic behavior on intrinsically labile RNAi-induced heterochromatin spread

Dissecting of the AI-2/LuxS Mediated Growth Characteristics and Bacteriostatic Ability of Lactiplantibacillus plantarum SS-128 by Integration of Transcriptomics and Metabolomics

Contact Info

Product

Resources

About