Aging, metabolic acidosis and renal failure: Interactive accelerating processes

Frassetto, Lynda; Sebastián, Anthony

doi:10.1016/j.mehy.2019.02.015

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The association of this imbalance with TL shortening in AN-B/P type has not been studied. However, extrapolating from studies in other populations shows that the metabolic acidosis seen in people with age-related renal dysfunction may lead to greater shortening of TL [61,62]. One should bear in mind, in this respect, that laxative abuse in patients with AN-B/P might lead to metabolic acidosis [6].…”

Section: Discussionmentioning

confidence: 98%

Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type

Uziel,

Dickstein,

Beery

et al. 2023

Nutrients

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Physiological and psychological distress may accelerate cellular aging, manifested by shortening of telomere length (TL). The present study focused on TL shortening in anorexia nervosa (AN), an illness combining physiological and psychological distress. For that purpose, we measured TL in 44 female adolescents with AN at admission to inpatient treatment, in a subset of 18 patients also at discharge, and in 22 controls. No differences in TL were found between patients with AN and controls. At admission, patients with AN-binge/purge type (AN-B/P; n = 18) showed shorter TL compared with patients with AN-restricting type (AN-R; n = 26). No change in TL was found from admission to discharge, despite an improvement in body mass index standard deviation score (BMI-SDS) following inpatient treatment. Older age was the only parameter assessed to be correlated with greater TL shortening. Several methodological changes have to be undertaken to better understand the putative association of shorter TL with B/P behaviors, including increasing the sample size and the assessment of the relevant pathological eating disorder (ED) and non-ED psychological correlates in the two AN subtypes.

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Section: Discussionmentioning

confidence: 98%

Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type

Uziel,

Dickstein,

Beery

et al. 2023

Nutrients

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“…Chronic acid‐base imbalance because of high acidic or alkaline food consumption creates an unfavourable metabolic situation resulting in the inability of buffering systems to resist that 10 . With increasing age, kidney and lung function decreases, and the buffering system is unable to maintain blood PH 11 . A healthy diet can have a beneficial effect on metabolic acidosis, which is associated with CVD rates 12 .…”

Section: Introductionmentioning

confidence: 99%

The association between dietary acid load with cardiometabolic risk factors and inflammatory markers amongst elderly men: A cross‐sectional study

Jafari

Ghanbari

Shahinfar

et al. 2021

Int J Clinical Practice

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Background Existing epidemiological data on dietary acid load and cardiovascular disease (CVD) are controversial. There is no literature evaluating the association between dietary acid load (DAL) with cardiometabolic risk factors and inflammatory markers in elderly. Objective To evaluate the association between DAL and cardiometabolic risk factors amongst Iranian elders. Method A cross‐sectional study was completed using 357 Iranian elders above >60 years of age. Anthropometric, clinical, and biochemical measurements were performed. Dietary intake was assessed using a validated and reliable food frequency questionnaire. DAL was estimated using the Potential Renal Acid Load (PRAL) score, Net Endogenous Acid Production (NEAP) and the Net Endogenous Acid Excretion (NAE) score. Metabolic syndrome (MetS) was defined according to the ATP‐III criteria. Multivariable‐adjusted odds ratios (ORs) of CVD risk factors were estimated using logistic regression. Results After adjustment for confounders, a higher PRAL score was associated with higher odds of hypertriglyceridemia (OR: 2.28, 95% CI: 1.15, 4.50). We also observed that the NEAP score was positively associated with MetS (OR: 17.2, 95% CI: 2.34, 127). Finally, there was a positive association between NAE and lipid accumulation product (LAP) (OR: 1.81, 95% CI: 1.04, 3.17) and hypertriglyceridemia (OR: 2.46 95% CI: 1.22, 4.95). Conclusion Men with higher DAL scores had a higher risk of MetS, hypertriglyceridemia and LAP. Our findings suggest that further prospective studies are required to appraise DAL‐CVD risk factors in populations with varying dietary patterns.

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Säure-Basen-Haushalt und Gelenkerkrankungen

Vormann¹,

Werner²

2021

Erfahrungsheilkunde

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ZusammenfassungDer pH-Wert des gesunden Menschen ist immens wichtig. Schon geringe Abweichungen führen zu massiven Störungen im Stoffwechsel, die unter Umständen lebensbedrohlich sind. Für den korrekten Ablauf biologischer Funktionen ist es wichtig, ein konstantes Verhältnis zwischen Säuren und Basen aufrechtzuerhalten. Ändert sich die Säurekonzentration, so hat das massive Auswirkungen auf die Aktivität von Enzymen oder die Struktur von Zellmembranen. Das Risiko für eine Schmerzentstehung ist insbesondere dann gegeben, wenn eine ernährungsbedingte Säurebelastung mit einer erhöhten Säureproduktion im Stoffwechsel zusammenkommt. Insgesamt gesehen belegen die Ergebnisse verschiedenster Untersuchungen die Bedeutung eines ausgeglichenen Säure-Basen-Haushalts auch bei Problemen im Gelenkbereich. Die Behebung einer alimentären Azidose durch ausreichende Basenzufuhr sollte Teil einer erfolgreichen Behandlung von Gelenkproblemen sein.

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Aging, metabolic acidosis and renal failure: Interactive accelerating processes

Cited by 3 publications

References 34 publications

Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type

Differences in Telomere Length between Adolescent Females with Anorexia Nervosa Restricting Type and Anorexia Nervosa Binge-Purge Type

The association between dietary acid load with cardiometabolic risk factors and inflammatory markers amongst elderly men: A cross‐sectional study

Säure-Basen-Haushalt und Gelenkerkrankungen

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