Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

Hamaguchi, Masahide; Kojima, Takao; Ohbora, Akihiro; Takeda, Noriyuki; Fukui, Michiaki; Kato, Takeshi

doi:10.3748/wjg.v18.i3.237

Cited by 118 publications

(106 citation statements)

References 26 publications

(33 reference statements)

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“…Although the present sample of PMW has revealed a higher frequency of NAFLD, it was lower among those who referred HRT use, similar to the findings described in another study (11) .…”

Section: Discussionsupporting

confidence: 79%

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Nonalcoholic Fatty Liver Disease in Menopausal Women

Florentino

Cotrim

Vilar

et al. 2013

Arq. Gastroenterol.

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-Context -Nonalcoholic Fatty Liver Disease (NAFLD) is common in postmenopausal women. It is associated with metabolic syndrome. However, the influence of hormone replacement therapy in NAFLD development in these women needs to be investigated. This study aimed to describe the clinical characteristics of NAFLD in postmenopausal women, and the relationship between hormone replacement therapy and this disease. (79/198) without hormone replacement therapy. Gamma-glutamyl transpeptidase (P = 0.001), alanine transaminase (P<0.01), ferritin (P<0.001) and insulin resistance (homeostatic model assessment of insulin resistance ≥3) (P<0.001) were higher in the group of women with NAFLD diagnosis who did not referred the use of hormone replacement therapy. Metabolic syndrome was also more frequent in women with NAFLD, who did not refer hormone replacement therapy. Conclusion -In conclusion this data suggests elevated prevalence of NAFLD in postmenopausal women; negative association of hormone replacement therapy and NAFLD. HEADINGS -Fatty Liver. Hormone replacement therapy.

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“…Although the present sample of PMW has revealed a higher frequency of NAFLD, it was lower among those who referred HRT use, similar to the findings described in another study (11) .…”

Section: Discussionsupporting

confidence: 79%

“…Hamaguchi et al (11) suggested that aging is a risk factor for NAFLD in premenopausal women, independent of weight gain or influence of MS. In addition, results from the authors showed higher frequency of NAFLD in PMW who did not use HRT when compared to premenopausal and postmenopausal women who referred HRT usage.…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease in Menopausal Women

Florentino

Cotrim

Vilar

et al. 2013

Arq. Gastroenterol.

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“…The early stage of NAFLD is "simple hepatic steatosis" with relatively good prognosis (6). However, the progression of nonalcoholic hepatic steatosis causes non-alcoholic steatohepatitis (NASH) (6), and eventually induces cirrhosis or hepatocellular carcinoma (7,8). Therefore, effective approaches for the prevention of hepatic steatosis are needed.…”

mentioning

confidence: 99%

“…Aging is a known risk factor for NAFLD (5,6). The early stage of NAFLD is "simple hepatic steatosis" with relatively good prognosis (6). However, the progression of nonalcoholic hepatic steatosis causes non-alcoholic steatohepatitis (NASH) (6), and eventually induces cirrhosis or hepatocellular carcinoma (7,8).…”

mentioning

confidence: 99%

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<small>L</small>-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice

Sato

Muramatsu

Ito

et al. 2018

J Nutr Sci Vitaminol

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Summary Non-alcoholic hepatic steatosis is a phenotype of metabolic syndrome, and aging is a risk factor for this condition. Senescence-accelerated mouse prone 8 (SAMP8) is a murine model for studying aging-associated disorders. We here investigated the effect of dietary supplementation with L-lysine (Lys) on non-alcoholic hepatic steatosis in SAMP8 mice. Triglyceride (TG) and cholesterol (Chol) accumulated in the livers of SAMP8 mice fed a standard diet at 36 wk of age. However, intake of a Lys-rich diet for 2 mo prevented the accumulation of TG and Chol in the liver. Plasma alanine aminotransferase activity, an index of liver injury, was decreased by Lys. The mRNA expression levels of peroxisome proliferator-activated receptor gamma coactivator 1-␣ and carnitine palmitoyltransferase 1a, which regulate ␤-oxidation, were increased in the livers of SAMP8 mice fed the Lys-rich diet. Taken together, our study suggests dietary intake of Lys prevents hepatic steatosis by stimulating ␤-oxidation in SAMP8 mice.

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Estrogen–ER‐α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women

Cherubini,

Casirati,

Pelusi

et al. 2024

Clinical & Translational Med

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Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women

Abstract: Aging is a risk factor for NAFLD in premenopausal women, independent of weight gain or influence of metabolic syndrome.

Cited by 118 publications

References 26 publications

Nonalcoholic Fatty Liver Disease in Menopausal Women

Nonalcoholic Fatty Liver Disease in Menopausal Women

<small>L</small>-Lysine Attenuates Hepatic Steatosis in Senescence-Accelerated Mouse Prone 8 Mice

Estrogen–ER‐α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women

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