Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment

Cao, Wenluo; Li, Lingna; Kajiura, Satoshi; Amoh, Yasuyuki; Tan, Yuying; Liu, Fang; Hoffman, Robert M.

doi:10.1080/15384101.2016.1156269

Cited by 11 publications

(13 citation statements)

References 29 publications

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“…A new focus has arisen around the role of the hair follicle environment in hair ageing 64,65 . A study by Cao et al 66 . used mice to transplant hair follicles from an old tissue environment to a young one and showed that some molecular processes could be reversed.…”

Section: Discussionmentioning

confidence: 99%

“…A new focus has arisen around the role of the hair follicle environment in hair ageing. 64,65 A study by Cao et al 66 used mice to transplant hair follicles from an old tissue environment to a young one and showed that some molecular processes could be reversed. Due to our lifespan, ageing studies in humans are more complicated and data are rather 67,68 Further research should focus on discerning the differences between hair ageing and androgenetic alopecia, which are commonly confused.…”

Section: Hair Ageingmentioning

confidence: 99%

See 1 more Smart Citation

Current controversies in trichology: a European expert consensus statement

Meyer-Gonzalez¹,

Bacqueville

Grimalt

et al. 2021

Acad Dermatol Venereol

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Introduction Hair disorders are one of the most common conditions within dermatology practice but, although new diagnostic tools and therapeutic options have arisen, the management of these patients still represents a major clinical challenge. ObjectiveThis study aimed at gathering information and achieving consensus on relevant recommendations on the latest advances in alopecia, trichoscopy and hair dermocosmetics.Methods Experts of the steering committee consulted the available evidence on trichology-related areas from the past 5 years and formulated recommendations based on the evidence and their experience. A modified two-round Delphi procedure was performed among 45 European dermatologists experts in trichology to consult their degree of agreement on twenty recommendations, using a 4-point Likert scale. Consensus was defined as >80% of participants scoring either 1 (totally agree) or 2 (agree). ResultsIn the first round of the Delphi questionnaire, 75% of the recommendations reached consensus. Those that were not agreed upon were reformulated by the steering committee and voted again after an online meeting, where consensus was achieved in all recommendations.Conclusions All recommendations reached consensus after the two-round Delphi questionnaire and may be useful in clinical practice for dermatologists. The participants agreed that besides this consensus, further clinical studies are needed to assess the benefits of the emerging tools and treatments and to clarify the controversies that still exist in the field, aiming at improving patients' quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Hair Ageingmentioning

confidence: 99%

Current controversies in trichology: a European expert consensus statement

Meyer-Gonzalez¹,

Bacqueville

Grimalt

et al. 2021

Acad Dermatol Venereol

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“…The study further revealed follistatin as an extracellular factor capable of inducing hair growth . Transplantation of hair follicle‐associated pluripotent, nestin‐expressing stem cells from aged mice to young mice displayed higher activity than those transplanted onto another aged mice, suggesting that they are involved in the follicular aging process which can be reversible …”

Section: Common Hair Loss Conditionsmentioning

confidence: 92%

Aging in hair follicle stem cells and niche microenvironment

et al. 2017

The Journal of Dermatology

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Hair graying and hair loss are prominent and common characteristics of the elderly population. In some individuals these processes can significantly impact their quality of life, leading to depression, anxiety and other serious mental health problems. Accordingly, there has been much interest in understanding the complex physiological changes within the hair follicle in the aging individual. It is now known that hair follicles represent a prototypical stem cell niche, where both micro- and macroenvironmental influences are integrated alongside stem cell-stem cell and stem cell-stem niche interactions to determine hair growth or hair follicle senescence. Recent studies have identified imbalanced stem cell differentiation and altered stem cell activity as important factors during hair loss, indicating new avenues for the development of therapeutic agents to stimulate hair growth. Here, we pull together the latest findings on the hair follicle stem cell niche and the multifactorial interactions underlying the various forms of hair loss.

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“…As activation of HFSCs is closely associated with their niche, extrinsic mechanisms also play important roles in HFSC aging. Several studies have demonstrated functional recovery of aged HFSCs relative to young HFSCs after their transplantation into the skin of a young mouse both in vivo and in vitro ( 88 - 91 ). Although the extrinsic mechanisms driving HFSC aging have not been clarified yet, several studies have shown the influence of extrinsic factors on HFSC aging.…”

Section: Extrinsic Mechanisms Reponsible For Hf Agingmentioning

confidence: 99%

Aging of hair follicle stem cells and their niches

Jang¹,

Jo²,

Lee³

et al. 2022

BMB Rep

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Hair follicles in the skin undergo cyclic rounds of regeneration, degeneration, and rest throughout life. Stem cells residing in hair follicles play a pivotal role in maintaining tissue homeostasis and hair growth cycles. Research on hair follicle aging and age-related hair loss has demonstrated that a decline in hair follicle stem cell (HFSC) activity with aging can decrease the regeneration capacity of hair follicles. This review summarizes our understanding of how age-associated HFSC intrinsic and extrinsic mechanisms can induce HFSC aging and hair loss. In addition, we discuss approaches developed to attenuate age-associated changes in HFSCs and their niches, thereby promoting hair regrowth.

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Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment

Cited by 11 publications

References 29 publications

Current controversies in trichology: a European expert consensus statement

Current controversies in trichology: a European expert consensus statement

Aging in hair follicle stem cells and niche microenvironment

Aging of hair follicle stem cells and their niches

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