Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

Hasegawa, Daisuke; Hori, Amane; Okamura, Yukiko; Baba, Reizo; Suijo, Kenichi; Mizuno, Masaki; Sugawara, Jun; Kitatsuji, Koji; Ogata, Haruhiko; Toda, Kaoru; Hotta, Nigishi

doi:10.14814/phy2.15125

Cited by 5 publications

(8 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Autonomic nervous system (ANS) regulates heart activity during exercise using signals from the central nervous system ( Williamson et al, 2006 ) and feedback mechanisms from the exercise pressor reflex (group III and IV muscle afferents) ( Kaufman and Hayes, 2002 ) and the arterial baroreflex, which controls blood pressure and consequently cardiac output ( Charkoudian et al, 2005 ). Previous studies have shown that exercise pressor reflex is impacted by aging ( Caron et al, 2018 ; Trinity et al, 2018 ; Hasegawa et al, 2021 ; Teixeira and Vianna, 2022 ), which would potentially alter the interconnection between the motor and cardiac systems. Nevertheless, the effect is still controversial and further research is needed to fully understand this interconnection pathway, which, in the current study, was quantified through CCM parameters.…”

Section: Discussionmentioning

confidence: 99%

Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems

Arrué,

Laksari,

Russo

et al. 2024

Front. Aging

View full text Add to dashboard Cite

Frailty is a geriatric syndrome associated with the lack of physiological reserve and consequent adverse outcomes (therapy complications and death) in older adults. Recent research has shown associations between heart rate (HR) dynamics (HR changes during physical activity) with frailty. The goal of the present study was to determine the effect of frailty on the interconnection between motor and cardiac systems during a localized upper-extremity function (UEF) test. Fifty-six individuals aged 65 or above were recruited and performed the previously developed UEF test consisting of 20-s rapid elbow flexion with the right arm. Frailty was assessed using the Fried phenotype. Wearable gyroscopes and electrocardiography were used to measure motor function and HR dynamics. In this study, the interconnection between motor (angular displacement) and cardiac (HR) performance was assessed, using convergent cross-mapping (CCM). A significantly weaker interconnection was observed among pre-frail and frail participants compared to non-frail individuals (p < 0.01, effect size = 0.81 ± 0.08). Using logistic models, pre-frailty and frailty were identified with sensitivity and specificity of 82%–89%, using motor, HR dynamics, and interconnection parameters. Findings suggested a strong association between cardiac-motor interconnection and frailty. Adding CCM parameters in a multimodal model may provide a promising measure of frailty.

show abstract

Section: Discussionmentioning

confidence: 99%

Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems

Arrué,

Laksari,

Russo

et al. 2024

Front. Aging

View full text Add to dashboard Cite

show abstract

“…However, whether this is due to alterations in the exercise pressor reflex is inconclusive. Several studies suggest that aging may augment the BP response to exercise (Trinity et al, 2018;Hasegawa et al, 2021). Frontiers in Physiology frontiersin.org Specifically, Hasegawa et al reported that healthy older subjects had a significantly higher systolic BP response to ischemic handgrip exercise compared to that in middle-age and young subjects, and proposed increased sensitivity of the exercise pressor reflex as a possible cause (Hasegawa et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies suggest that aging may augment the BP response to exercise ( Trinity et al, 2018 ; Hasegawa et al, 2021 ). Specifically, Hasegawa et al reported that healthy older subjects had a significantly higher systolic BP response to ischemic handgrip exercise compared to that in middle-age and young subjects, and proposed increased sensitivity of the exercise pressor reflex as a possible cause ( Hasegawa et al, 2021 ). Conversely, other studies have shown that healthy older subjects had an attenuated BP response to progressive ischemic handgrip exercise compared to that in younger subjects ( Markel et al, 2003 ), suggesting an attenuated metaboreflex.…”

Section: Discussionmentioning

confidence: 99%

“…Previous findings on the effect of aging on the pressor responses to exercise are inconclusive. Several studies have reported that the BP response to exercise was significantly higher in older adults compared to younger adults ( Hasegawa et al, 2021 ; O'Connor et al, 2015 ; Petrofsky and Lind, 1975 ). Whereas other studies reported similar or even lower BP responses to exercise in older adults compared to young adults ( Sagiv et al, 1988 ; Taylor et al, 1991 ; Markel et al, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exaggerated exercise pressor reflex in male UC Davis type 2 diabetic rats is due to the pathophysiology of the disease and not aging

et al. 2023

View full text Add to dashboard Cite

Introduction: Studies in humans and animals have found that type 2 diabetes mellitus (T2DM) exaggerates the blood pressure (BP) response to exercise, which increases the risk of adverse cardiovascular events such as heart attack and stroke. T2DM is a chronic disease that, without appropriate management, progresses in severity as individuals grow older. Thus, it is possible that aging may also exaggerate the BP response to exercise. Therefore, the purpose of the current study was to determine the effect of the pathophysiology of T2DM on the exercise pressor reflex independent of aging.Methods: We compared changes in peak pressor (mean arterial pressure; ΔMAP), BP index (ΔBPi), heart rate (ΔHR), and HR index (ΔHRi) responses to static contraction, intermittent contraction, and tendon stretch in UCD-T2DM rats to those of healthy, age-matched Sprague Dawley rats at three different stages of the disease.Results: We found that the ΔMAP, ΔBPi, ΔHR, and ΔHRi responses to static contraction were significantly higher in T2DM rats (ΔMAP: 29 ± 4 mmHg; ΔBPi: 588 ± 51 mmHg•s; ΔHR: 22 ± 5 bpm; ΔHRi: 478 ± 45 bpm•s) compared to controls (ΔMAP: 10 ± 1 mmHg, p < 0.0001; ΔBPi: 121 ± 19 mmHg•s, p < 0.0001; ΔHR: 5 ± 2 bpm, p = 0.01; ΔHRi: 92 ± 19 bpm•s, p < 0.0001) shortly after diabetes onset. Likewise, the ΔMAP, ΔBPi, and ΔHRi to tendon stretch were significantly higher in T2DM rats (ΔMAP: 33 ± 7 mmHg; ΔBPi: 697 ± 70 mmHg•s; ΔHRi: 496 ± 51 bpm•s) compared to controls (ΔMAP: 12 ± 5 mmHg, p = 0.002; ΔBPi: 186 ± 30 mmHg•s, p < 0.0001; ΔHRi: 144 ± 33 bpm•s, p < 0.0001) shortly after diabetes onset. The ΔBPi and ΔHRi, but not ΔMAP, to intermittent contraction was significantly higher in T2DM rats (ΔBPi: 543 ± 42 mmHg•s; ΔHRi: 453 ± 53 bpm•s) compared to controls (ΔBPi: 140 ± 16 mmHg•s, p < 0.0001; ΔHRi: 108 ± 22 bpm•s, p = 0.0002) shortly after diabetes onset.Discussion: Our findings suggest that the exaggerated exercise pressor reflex and mechanoreflex seen in T2DM are due to the pathophysiology of the disease and not aging.

show abstract

“…Due to conflicting findings, the effects of aging, independent of pathology and physical activity levels, on the exercise pressor reflex are unclear and controversial. Indeed, reports have suggested that the BP response to reflex activation is blunted (Markel et al, 2003), preserved (Ng et al, 1994;Momen et al, 2004;Houssiere et al, 2006;Roseguini et al, 2007;Greaney et al, 2013;Sidhu et al, 2015), or exaggerated (Choi et al, 2012;Schneider et al, 2018;Hasegawa et al, 2021;Wenner et al, 2022). Thus, this review aims to address these discrepant findings and provide a brief overview of the current understanding of the influence of aging on the cardiovascular responses to exercise, focusing on the role of the exercise pressor reflex and proposing future directions for this critical area of research.…”

Section: Introductionmentioning

confidence: 99%

Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex

Grotle,

Langlo,

Holsbrekken

et al. 2023

Front. Physiol.

View full text Add to dashboard Cite

Autonomic adjustments of the cardiovascular system are critical for initiating and sustaining exercise by facilitating the redistribution of blood flow and oxygen delivery to meet the metabolic demands of the active skeletal muscle. Afferent feedback from active skeletal muscles evokes reflex increases in sympathetic nerve activity and blood pressure (BP) (i.e., exercise pressor reflex) and contributes importantly to these primary neurovascular adjustments to exercise. When altered, this reflex contributes significantly to the exaggerated sympathetic and BP response to exercise observed in many cardiovascular-related diseases, highlighting the importance of examining the reflex and its underlying mechanism(s). A leading risk factor for the pathogenesis of cardiovascular disease in both males and females is aging. Although regular exercise is an effective strategy for mitigating the health burden of aging, older adults face a greater risk of experiencing an exaggerated cardiovascular response to exercise. However, the role of aging in mediating the exercise pressor reflex remains highly controversial, as conflicting findings have been reported. This review aims to provide a brief overview of the current understanding of the influence of aging on cardiovascular responses to exercise, focusing on the role of the exercise pressor reflex and proposing future directions for research. We reason that this review will serve as a resource for health professionals and researchers to stimulate a renewed interest in this critical area.

show abstract

Aging exaggerates blood pressure response to ischemic rhythmic handgrip exercise in humans

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 47 publications

Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems

Associating frailty and dynamic dysregulation between motor and cardiac autonomic systems

Exaggerated exercise pressor reflex in male UC Davis type 2 diabetic rats is due to the pathophysiology of the disease and not aging

Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex

Contact Info

Product

Resources

About