Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia

Yin, Lu; Zheng, Dahai; Limmon, Gino V.; Leung, Nicola H. N.; Xu, Shuoyu; Rajapakse, Jagath C.; Yu, Hanry; Chow, Vincent T.K.; Chen, Jianzhu

doi:10.1186/preaccept-1989848861132152

Cited by 13 publications

(17 citation statements)

References 38 publications

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“…As a result, loss of tissue integrity allows the lungs to be more susceptible to secondary bacterial infections. This is also shown in a mouse model where the aged mouse exhibits exacerbated damage of lung tissues and alveolar epithelia following influenza virus and pneumonia infection (Yin et al, 2014;Liew et al, 2014).…”

Section: Complications Of Secondary Bacterial Infections In the Elderlymentioning

confidence: 92%

DAMPs and influenza virus infection in ageing

Samy

Lim

2015

Ageing Research Reviews

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Section: Complications Of Secondary Bacterial Infections In the Elderlymentioning

confidence: 92%

DAMPs and influenza virus infection in ageing

Samy

Lim

2015

Ageing Research Reviews

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“…COPD is a disease that accelerates aging of the lungs and is closely associated with other aging effects [76]. Aging leads to a decrease in the number and activity of stem cells in the trachea tissue and a consequence is a significant decrease in the ability to repair tissue [77]. Elderly patients with COPD have significantly reduced stem cell numbers and activity.…”

Section: Application Of Msc Therapy For Copdmentioning

confidence: 99%

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

et al. 2020

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Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Given that COPD and inflammaging share similar general features, it is very important to identify the specific mechanisms of inflammaging, which involve oxidative stress, inflammation and lung mesenchymal stem cell function in the development of COPD, especially in elderly COPD patients. In this review, we highlight the studies relevant to COPD progression, and focus on mechanisms associated with inflammaging.

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“…Few studies have looked into the effect of ageing on lung stem cells. Yin et al () showed that influenza viral infections cause a more extensive loss of alveolar type 1 (AT1) and type 2 (AT2; stem) cells and delayed recovery of AT2 cells in aged mice. Furthermore, Wansleeben, Bowie, Hotten, Yu, and Hogan () showed that ageing results in fewer tracheal basal stem cells, although it did not result in their functional impairment when examined in an in vitro assay and with an in vivo injury model.…”

Section: Introductionmentioning

confidence: 99%

Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes

Hegab

Ozaki

Meligy

et al. 2019

J Tissue Eng Regen Med

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Ageing is associated with decreased lung function and an increased incidence of lung infections. Several studies have suggested that long-term calorie restriction (CR) promotes health and longevity and results in the reduced risk of several diseases.The effect of CR is thought to be through improving the function of tissue stem cells.Stem cell function is known to decline with ageing. In this study, we examined the effects of ageing on lung epithelial and stem cells and the effect of CR on young and old lungs. We found that ageing results in a decrease in tracheal basal stem cells.CR induced an increase in basal stem cells in both young and old mice. In addition, ageing induced lung inflammation, and CR tended to reduce baseline lung inflammatory cell infiltration in young mice and significantly reduced ageing-induced lung inflammation. Furthermore, ageing reduced the number and function of mitochondria in lung and increased the level of mitochondrial reactive oxygen species. CR increased the number and function of mitochondria both in young and old mice. Moreover, ageing reduced lung stem cell colony-forming efficiency (CFE), and CR increased the CFE in both young and old mice. Finally, CR improved epithelial cell survival in injured lungs of young mice. In conclusion, ageing causes several structural and functional changes/impairments in lung epithelial cells. CR induces several potentially beneficial changes in lung epithelial cells, even when it is initiated at an older age, including reversal of some ageing-induced changes.

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Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia

Cited by 13 publications

References 38 publications

DAMPs and influenza virus infection in ageing

DAMPs and influenza virus infection in ageing

Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease

Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing-induced changes

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