Aging: Effects on the prostaglandin production by skeletal muscle of male rhesus monkeys (Macaca mulatta)

Young, Michal; Bocek, Rose Mary; Herrington, P. T.; Beatty, Clarissa H.

doi:10.1016/0047-6374(81)90018-x

Cited by 12 publications

(4 citation statements)

References 17 publications

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“…Alternatively enhanced mechanical response of muscle C‐fiber afferents might be caused by prostaglandins which are well known as sensitizing agents of nociceptors. Their productions in the sartorius muscle of aged rhesus monkeys was reported to be about two times higher than that of the young ones (Young et al, 1981). However, it is not known whether this is also the case in rats, because no report is available for the moment about the prostaglandin production in the aged rats.…”

Section: Discussionmentioning

confidence: 99%

Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Taguchi

Mizumura

2011

European Journal of Pain

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Musculoskeletal pain deteriorates quality of life by disrupting daily activities and is a considerable economic burden to many countries because of the large number of patients. Little is known about the peripheral neural mechanisms of muscular nociception in the aged, although structural and functional changes in the muscle are apparent as a function of age. The aim of the present study was to investigate the activities of aged muscle nociceptors systematically to mechanical, chemical and thermal stimuli, and to compare with the data from young animals. Activities of single C-fibers were recorded from in vitro preparations of extensor digitorum longus muscle-nerve excised from hind legs of aged rats (125-133 weeks). Mechanical threshold measured by a ramp mechanical stimulus in the aged muscle (median; 45.2 mN (IQR; 38.1-59.1 mN), n=29) was significantly lower than that in the younger muscle (median; 65.4 mN (IQR; 46.6-122.0 mN), n=33, p<0.01, Mann-Whitney U-test) reported in our previous study (Taguchi et al., 2005). In addition, the magnitude of the mechanical response during the first 5s of the 10s stimulus was significantly greater in the aged muscle (11.0 spikes (IQR; 6.5-20.5 spikes)) than in the young (7.0 spikes (IQR; 4.0-11.5 spikes), p<0.05, Mann-Whitney U-test). In contrast, the numbers of discharges induced by chemical (pH 5.5, ATP and bradykinin) and thermal (cold and heat) stimuli were not different with the different ages. These results showed an augmented mechanical response in muscle C-afferents in the aged rats.

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Section: Discussionmentioning

confidence: 99%

Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Taguchi

Mizumura

2011

European Journal of Pain

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“…The macrophages from old mice are reported to produce more PGE 2 than young mice, indi- (Hayek et al, 1997). Young et al (1981) studied the effects of age on PG production in the skeletal muscle of male rhesus monkeys. They found that total PG production in the aged animal was about twice that of the young animals.…”

Section: Effects Of Prostaglandins and Cyclooxygenase-2mentioning

confidence: 99%

Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction

Chung

Kim

et al. 2002

Microscopy Res & Technique

274

186

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Accumulating evidence strongly suggests that oxidative stress underlies aging processes. Research provides consistent evidence that calorie restriction (CR) reduces age-related oxidative stress and has anti-inflammatory properties. However, information is lacking on the molecular mechanism that would better define the interrelation of reactive oxygen species and nitrogen species and the pro-inflammatory states of the aging process. In this review, the biochemical and molecular bases of the inflammatory process in the aging process are analyzed to delineate the molecular inflammation hypothesis of aging. The key players involved in the proposed hypothesis are the age-related upregulation of NF-kappa B, IL-1 beta, IL-6, TNFalpha, cyclooxygenase-2, and inducible NO synthase, all of which are attenuated by CR. Furthermore, age-related NF kappa B activation is associated with phosphorylation by I kappa B kinase/NIK and MAPKs, while CR blocked these activation processes. The modulation of these factors provides molecular insights of the anti-inflammatory action of CR in relation to the aging process. Based on available finding and our recent supporting evidence, we prefer to use "molecular inflammation" to emphasize the importance of the molecular reaction mechanisms and their aberrance, predisposing to fully expressed chronic inflammatory phenomena. It was further proposed that CR's major force of the regulation of redox-sensitive inflammation may well be its life-prolonging action.

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“…This same ratio of PGE 2 to PGF 2␣ appears to hold in resting skeletal muscle of older individuals as well (33). However, studies in skeletal muscle of rhesus monkeys show that PG production is approximately twofold higher in older muscle compared with young (142). Several studies in humans using the microdialysis technique to sample the muscle interstitial fluid provide additional information on intramuscular levels of the PGs (primarily PGE 2 ).…”

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confidence: 99%

Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise

Trappe

Liu

2013

Journal of Applied Physiology

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Trappe TA, Liu SZ. Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise. J Appl Physiol 115: 909 -919, 2013. First published March 28, 2013 doi:10.1152/japplphysiol.00061.2013.-It has been ϳ40 yr since the discovery that PGs are produced by exercising skeletal muscle and since the discovery that inhibition of PG synthesis is the mechanism of action of what are now known as cyclooxygenase (COX)-inhibiting drugs. Since that time, it has been established that PGs are made during and after aerobic and resistance exercise and have a potent paracrine and autocrine effect on muscle metabolism. Consequently, it has also been determined that orally consumed doses of COX inhibitors can profoundly influence muscle PG synthesis, muscle protein metabolism, and numerous other cellular processes that regulate muscle adaptations to exercise loading. Although data from acute human exercise studies, as well as animal and cell-culture data, would predict that regular consumption of a COX inhibitor during exercise training would dampen the typical muscle adaptations, the chronic data do not support this conjecture. From the studies in young and older individuals, lasting from 1.5 to 4 mo, no interfering effects of COX inhibitors on muscle adaptations to resistance-exercise training have been noted. In fact, in older individuals, a substantial enhancement of muscle mass and strength has been observed. The collective findings of the PG/COX-pathway regulation of skeletal muscle responses and adaptations to exercise are compelling. Considering the discoveries in other areas of COX regulation of health and disease, there is certainly an interesting future of investigation in this re-emerging area, especially as it pertains to older individuals and the condition of sarcopenia, as well as exercise training and performance of individuals of all ages. PGE 2; PGF2␣; acetaminophen; ibuprofen; sarcopenia PGS PRODUCED BY the cyclooxygenase (COX) enzyme are ubiquitous in human physiology and regulate numerous processes (105, 108), including muscle protein metabolism (78,93,106,126,128). As a result, PGs regulate adaptations to muscular exercise, and COX-inhibiting drugs can alter the acute and chronic responses to exercise. Because of the continuum of acute responses and chronic adaptations that exists from lowerintensity, longer-duration exercise to higher-intensity, shorterduration exercise, it is difficult to adopt a "one-mechanismfits-all" approach to PG and COX involvement in skeletal muscle exercise adaptations. This is also true when distinguishing between muscle injury and muscular exercise for health and performance.COX-inhibiting drugs are one of the most commonly consumed classes of drugs in the world. In the United States, the COX inhibitors, acetaminophen, ibuprofen, and aspirin, are the top three consumed drugs of young, middle-aged, and older individuals, with ϳ50 million individuals using each of these drugs during any given week (52, 129). Interestingly, two of these drugs (acetaminophen...

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Aging: Effects on the prostaglandin production by skeletal muscle of male rhesus monkeys (Macaca mulatta)

Cited by 12 publications

References 17 publications

Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Augmented mechanical response of muscular thin‐fiber receptors in aged rats recorded in vitro

Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction

Effects of prostaglandins and COX-inhibiting drugs on skeletal muscle adaptations to exercise

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