2022
DOI: 10.3389/fendo.2022.952471
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Abstract: Progressive loss of physiological integrity and accumulation of degenerative changes leading to functional impairment and increased susceptibility to diseases are the main features of aging. The ovary, the key organ that maintains female reproductive and endocrine function, enters aging earlier and faster than other organs and has attracted extensive attention from society. Ovarian aging is mainly characterized by the progressive decline in the number and quality of oocytes, the regulatory mechanisms of which … Show more

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Cited by 18 publications
(7 citation statements)
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“…The conversion of a pluripotent VSEL with open chromatin into OSCs involves extensive epigenetic changes, and this process is affected by aging. Ovarian aging can be reversed by transplanting MSCs directly into the ovaries ( Tian et al, 2021 ; Wu et al, 2022 ) and by providing a younger niche. Aged ovaries possess rare premeiotic germ cells that can generate oocytes, following transplantation into a young host environment ( Niikura et al, 2009 ).…”
Section: Introductionmentioning
confidence: 99%
“…The conversion of a pluripotent VSEL with open chromatin into OSCs involves extensive epigenetic changes, and this process is affected by aging. Ovarian aging can be reversed by transplanting MSCs directly into the ovaries ( Tian et al, 2021 ; Wu et al, 2022 ) and by providing a younger niche. Aged ovaries possess rare premeiotic germ cells that can generate oocytes, following transplantation into a young host environment ( Niikura et al, 2009 ).…”
Section: Introductionmentioning
confidence: 99%
“…Ovarian aging is a complex process resulting in senescence in mice and menopause in women and a topic of intense debate and several possible underlying mechanisms are discussed [26,27]. It eventually results in the aging of multiple organs and menopausal women suffer from a number of diseases like osteoporosis, cardiovascular disease, obesity, tumors, Alzheimer's disease and diabetes.…”
Section: Main Textmentioning
confidence: 99%
“…Thus, mitochondrial dysfunction is a common feature of both oocytes and stem cells in aging. Defective mitochondria in aged oocytes increase ROS levels ( Wu et al, 2022 ). HSCs also exhibit increased ROS production during aging ( Nakamura-Ishizu et al, 2020 ).…”
Section: Oocyte Agingmentioning
confidence: 99%
“…Furthermore, before menopause, decline in oocyte function accompanies the decrease in their numbers with aging. In aged oocytes, chromosome aneuploidy increases and mitochondrial function declines (Wu et al, 2022). Meanwhile, the number of tissue stem cells also decreases with aging, and it could be hypothesized that oocytes and stem cells share common aging phenotypes.…”
Section: Introductionmentioning
confidence: 99%