Aging, Brain, and Mobility: Progress and Opportunities

Rosano, Caterina; Rosso, Andrea L.; Studenski, Stephanie A.

doi:10.1093/gerona/glu159

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Cognitive changes have been found to be contributors to limitations in mobility, including among older adults without known neurological disease (Rosso et al, 2013); whereas, increased aerobic activity is associated with improved brain health and cognitive function in health older adults (Erickson et al, 2011). The linkages among cognition, mood, and physical health is likely due to common underlying pathologies that cause general slowing of neurological function, and clinical manifestations in each of these domains (Rosano et al, 2014). …”

Section: Discussionmentioning

confidence: 99%

Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review

Rodakowski

Saghafi

Butters

et al. 2015

Molecular Aspects of Medicine

176

124

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The purpose of this scoping review was to examine the science related to non-pharmacological interventions designed to slow decline for older adults with Mild Cognitive Impairment or early-stage dementia. We reviewed 32 unique randomized controlled trials that employed cognitive training (remediation or compensation approaches), physical exercise, or psychotherapeutic interventions that were published before November 2014. Evidence suggests that cognitive training focused on remediation and physical exercise interventions may promote small improvements in selected cognitive abilities. Cognitive training focused on compensation interventions and selected psychotherapeutic interventions may influence how cognitive changes impact daily living. However, confidence in these findings is limited due methodological limitations. To better assess the value of non-pharmacological interventions for this population, we recommend: 1) adoption of universal criteria for “early stage cognitive decline” among studies, 2) adherence to guidelines for the conceptualization, operationalization, and implementation of complex interventions, 3) consistent characterization of the impact of interventions on daily life, and 3) long-term follow-up of clinical outcomes to assess maintenance and meaningfulness of reported effects over time.

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Section: Discussionmentioning

confidence: 99%

Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review

Rodakowski

Saghafi

Butters

et al. 2015

Molecular Aspects of Medicine

176

124

View full text Add to dashboard Cite

show abstract

“…Recent evidence suggests that the aging-induced decrease in neurovascular coupling can be restored by pharmacological interventions (88), offering a potential target for pharmacological interventions to promote brain health in the elderly patients. Restoration of a key homeostatic mechanism matching energy supply with the needs of active neuronal tissue is expected to have beneficial effects on multiple aspects of brain function (17,(100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110)(111)(112)(113)(114) in aging.…”

Section: Cerebrovascular Agingmentioning

confidence: 99%

Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment

Deák

Freeman

Ungvári

et al. 2015

GERONA

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As the population of the Western world is aging, there is increasing awareness of age-related impairments in cognitive function and a rising interest in finding novel approaches to preserve cerebral health. A special collection of articles in The Journals of Gerontology: Biological Sciences and Medical Sciences brings together information of different aspects of brain aging, from latest developments in the field of neurodegenerative disorders to cerebral microvascular mechanisms of cognitive decline. It is emphasized that although the cellular changes that occur within aging neurons have been widely studied, more research is required as new signaling pathways are discovered that can potentially protect cells. New avenues for research targeting cellular senescence, epigenetics, and endocrine mechanisms of brain aging are also discussed. Based on the current literature it is clear that understanding brain aging and reducing risk for neurological disease with age requires searching for mechanisms and treatment options beyond the age-related changes in neuronal function. Thus, comprehensive approaches need to be developed that address the multiple, interrelated mechanisms of brain aging. Attention is brought to the importance of maintenance of cerebromicrovascular health, restoring neuroendocrine balance, and the pressing need for funding more innovative research into the interactions of neuronal, neuroendocrine, inflammatory and microvascular mechanisms of cognitive impairment, and Alzheimer's disease.

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“…An estimated 1 in 3 older adults falls every year, 71 and it is thought that changes in the aging brain might play a central role in aging-associated mobility decline. 63 One potential consequence of falling is a fear of falling syndrome in which older adults become increasingly sedentary, further increasing their risk of falls, and fear of falling recently has been shown to contribute to sedentary behavior in older adults with chronic musculoskeletal pain. 67 Others have shown that pain itself is a risk factor for falls.…”

Section: Biological Aging Changes: Nervous Systemmentioning

confidence: 99%

Applying a Lifespan Developmental Perspective to Chronic Pain: Pediatrics to Geriatrics

Walco

Krane

Schmader

et al. 2016

The Journal of Pain

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Aging, Brain, and Mobility: Progress and Opportunities

Cited by 9 publications

References 6 publications

Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review

Non-pharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review

Recent Developments in Understanding Brain Aging: Implications for Alzheimer’s Disease and Vascular Cognitive Impairment

Applying a Lifespan Developmental Perspective to Chronic Pain: Pediatrics to Geriatrics

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