Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes

CD28 and CD57 define four populations with distinct phenotypic properties within human CD8+ T cells

“…B). CD28 + CD57 − CD8 + T cells decrease with age whereas CD28 − CD57 + CD8 + T cells increase (data not shown), corroborating earlier reports and results in our group . Whether age also affects the frequencies of DP and DN CD8 + T cells is currently unknown.…”

“…). Despite this theory, a population of CD28 + CD57 + CD8 + T cells has also been identified in the peripheral blood (PB), indicating that the linear CD28/CD57 CD8 + T cell differentiation model may be more complex than previously thought . In addition, it has been suggested that CD8 + T cell terminal differentiation may only be dependent on CD57 .…”

“…It has been suggested that, after repeated contact with antigens, activated CD28 + CD57 − CD8 + T cells may first reduce the surface expression of CD28, therefore becoming CD28 − CD57 − , and then express CD57, consequently acquiring the phenotype of terminally differentiated CD28 − CD57 + CD8 + T cells (reviewed by Strioga et al [15]). Despite this theory, a population of CD28 + CD57 + CD8 + T cells has also been identified in the peripheral blood (PB), indicating that the linear CD28/CD57 CD8 + T cell differentiation model may be more complex than previously thought [14,16]. In addition, it has been suggested that CD8 + T cell terminal differentiation may only be dependent on CD57 [14].…”

Shifts in subsets of CD8+ T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: an observational case-control study

“…Senescent T-cells have been phenotypically described by their loss of CD28 expression [ 31 ], and/or the expression of CD57 [ 1 , 3 ]. Others and our group have shown that the expression of CD57 (found on both CD28-CD57+ and CD28+CD57+ cells) was associated with pronounced characteristics of senescent cells such as loss of proliferation capacity in vitro, telomere attrition, increased expression of cyclin dependent kinase (CDK) inhibitors – p16 and p21, and the higher presence of these cells in elderly than in young humans [ 1 – 3 , 32 ]. The cells also showed a cytokine secretion profile analogous to the senescence associated secretary phenotypes [ 1 , 33 , 34 ].…”

“…The cells also showed a cytokine secretion profile analogous to the senescence associated secretary phenotypes [ 1 , 33 , 34 ]. CD28+CD57+ and CD28-CD57+ cells were found to have different homing and differentiation characteristics, which might point to a different origin for both senescent phenotypes [ 32 ]. While the CD28-CD57+ cells, also considered as terminally differentiated effector memory cells, and the CD28-CD57- cells, considered as effector memory cells, might not provide good anti-tumour immunity but more adverse effects, the CD28+CD57- cells, because of their enrichment with naïve and central memory cells, and their characteristic homing to secondary lymphoid organs, would provide better immunity against cancer [ 1 , 32 , 35 ].…”