Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Siddharth, Jay; Chakrabarti, Anirikh; Pannérec, Alice; Karaz, Sonia; Morin‐Rivron, Delphine; Masoodi, Mojgan; Feige, Jérôme N.; Parkinson, Scott J.

doi:10.18632/aging.101262

Cited by 99 publications

(115 citation statements)

References 50 publications

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“…The existence of a gut microbiota profile associated with sarcopenia and involving changes in the abundance of health-related Bifidobacteria has previously been shown in rats [43]. While very little is known about a possible functional link between Oscillospira and PF&S, the existence of a trait for butyrate-producing bacteria Ruminococcus is in-keeping with previously reported associations between Ruminococcus abundance and frailty [40].…”

Section: Discussionsupporting

confidence: 80%

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

et al. 2019

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Physical frailty and sarcopenia (PF&S) share multisystem derangements, including variations in circulating amino acids and chronic low-grade inflammation. Gut microbiota balances inflammatory responses in several conditions and according to nutritional status. Therefore, an altered gut-muscle crosstalk has been hypothesized in PF&S. We analyzed the gut microbial taxa, systemic inflammation, and metabolic characteristics of older adults with and without PF&S. An innovative multi-marker analytical approach was applied to explore the classification performance of potential biomarkers for PF&S. Thirty-five community dwellers aged 70+, 18 with PF&S, and 17 nonPF&S controls were enrolled. Sequential and Orthogonalized Covariance Selection (SO-CovSel), a multi-platform regression method developed to handle highly correlated variables, was applied. The SO-CovSel model with the best prediction ability using the smallest number of variables was built using seven mediators. The model correctly classified 91.7% participants with PF&S and 87.5% nonPF&S controls. Compared with the latter group, PF&S participants showed higher serum concentrations of aspartic acid, lower circulating levels of concentrations of threonine and macrophage inflammatory protein 1α, increased abundance of Oscillospira and Ruminococcus microbial taxa, and decreased abundance of Barnesiellaceae and Christensenellaceae. Future investigations are warranted to determine whether these biomediators are involved in PF&S pathophysiology and may, therefore, provide new targets for interventions.

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Section: Discussionsupporting

confidence: 80%

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

et al. 2019

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“…The microbiota can also influence muscle mass, as reported by Ticinesi et al [13]. Sarcopenia rat models exhibit a reduction of several taxa with anti-inflammatory and pro-anabolic effects in gut microbiota [14]. To compensate for their increased energy consumption and maximize their adaptation to physical loads, athletes must adopt adequate dietary habits, which increasingly include a broad range of sports nutritional supplements.…”

Section: Introductionmentioning

confidence: 99%

Mutual Interactions among Exercise, Sport Supplements and Microbiota

et al. 2019

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The adult gut microbiota contains trillions of microorganisms of thousands of different species. Only one third of gut microbiota are common to most people; the rest are specific and contribute to enhancing genetic variation. Gut microorganisms significantly affect host nutrition, metabolic function, immune system, and redox levels, and may be modulated by several environmental conditions, including physical activity and exercise. Microbiota also act like an endocrine organ and is sensitive to the homeostatic and physiological changes associated with training; in turn, exercise has been demonstrated to increase microbiota diversity, consequently improving the metabolic profile and immunological responses. On the other side, adaptation to exercise might be influenced by the individual gut microbiota that regulates the energetic balance and participates to the control of inflammatory, redox, and hydration status. Intense endurance exercise causes physiological and biochemical demands, and requires adequate measures to counteract oxidative stress, intestinal permeability, electrolyte imbalance, glycogen depletion, frequent upper respiratory tract infections, systemic inflammation and immune responses. Microbiota could be an important tool to improve overall general health, performance, and energy availability while controlling inflammation and redox levels in endurance athletes. The relationship among gut microbiota, general health, training adaptation and performance, along with a focus on sport supplements which are known to exert some influence on the microbiota, will be discussed.

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“…The presence of a gut-muscle axis in the pathogenesis of age-related sarcopenia in humans has been proposed recently based on very promising results(67). The interplay between microbiome and skeletal muscle has been highlighted by Siddhart and colleagues(64) who demonstrated that age-related changes of gut microbiome are associated with the physiological decline of musculoskeletal function. Future studies will be needed to identify the bacterial species and/or the underlying mechanisms and the putative metabolites that contribute to the functional link between gut microbiota and skeletal muscle.…”

mentioning

confidence: 99%

Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis

Nay

Jollet

Goustard

et al. 2019

American Journal of Physiology-Endocrinology and Metabolism

152

189

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Gut microbiota is involved in the development of several chronic diseases, including diabetes, obesity, and cancer, through its interactions with the host organs. It has been suggested that the cross talk between gut microbiota and skeletal muscle plays a role in different pathological conditions, such as intestinal chronic inflammation and cachexia. However, it remains unclear whether gut microbiota directly influences skeletal muscle function. In this work, we studied the impact of gut microbiota modulation on mice skeletal muscle function and investigated the underlying mechanisms. We determined the consequences of gut microbiota depletion after treatment with a mixture of a broad spectrum of antibiotics for 21 days and after 10 days of natural reseeding. We found that, in gut microbiota-depleted mice, running endurance was decreased, as well as the extensor digitorum longus muscle fatigue index in an ex vivo contractile test. Importantly, the muscle endurance capacity was efficiently normalized by natural reseeding. These endurance changes were not related to variation in muscle mass, fiber typology, or mitochondrial function. However, several pertinent glucose metabolism markers, such as ileum gene expression of short fatty acid chain and glucose transporters G protein-coupled receptor 41 and sodium-glucose cotransporter 1 and muscle glycogen level, paralleled the muscle endurance changes observed after treatment with antibiotics for 21 days and reseeding. Because glycogen is a key energetic substrate for prolonged exercise, modulating its muscle availability via gut microbiota represents one potent mechanism that can contribute to the gut microbiota-skeletal muscle axis. Taken together, our results strongly support the hypothesis that gut bacteria are required for host optimal skeletal muscle function.

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Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Cited by 99 publications

References 50 publications

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Gut Microbial, Inflammatory and Metabolic Signatures in Older People with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

Mutual Interactions among Exercise, Sport Supplements and Microbiota

Gut bacteria are critical for optimal muscle function: a potential link with glucose homeostasis

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