Aging and Innate Immunity

Solana, Rafael; Pawelec, Graham; Tarazona, Raquel

doi:10.1016/j.immuni.2006.05.003

Cited by 272 publications

(207 citation statements)

References 26 publications

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“…In spite of a chronic inflammatory state, aging has been thought to involve immunosenescence with deficient innate as well as adaptive immune response. [39][40][41][42] Mast cells are considered to be the first line of defense against allergens and pathogens and thus are important initiators of innate immune response. [43][44][45][46][47] Various inflammatory and chemotactic molecules produced and released from mast cells in response to foreign allergens or pathogens help recruitment of other antigen presenting cells at the site of inflammation and participate in shaping the host adaptive response.…”

Section: Aged Lymphatic Contractilitymentioning

confidence: 99%

“…Taken together, our findings indicate that in aging, mesenteric mast cells have reduced ability to be activated by acute inflammatory stimuli. While deficient immune cell function has been reported in aging, [39][40][41][42] there is no detailed information on the aging-associated alterations of mast cells and how they affect the function of mesenteric lymphatic vessels. The limited number of aged mast cells located in the mesentery to react to the presence of acute stimuli may be considered contributory to the aging-associated deteriorations in immune response.…”

Section: Aged Lymphatic Contractilitymentioning

confidence: 99%

See 1 more Smart Citation

Aged Lymphatic Contractility: Recent Answers and New Questions

Gashev

Chatterjee

2013

Lymphatic Research and Biology

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An overview is presented of recent findings related to biology of aging of the lymph transport system. The authors discuss recently obtained data on the aging-associated alterations of lymphatic contractility in thoracic duct and mesenteric lymphatic vessels; on comparisons of function of aged mesenteric lymphatic vessels in situ versus isolated specimens and important conclusions which arose from these studies; on aging-associated changes in functional status of mast cells located close to aged mesenteric lymphatic vessels; on evidence of presence of oxidative stress in aged lymphatic vessels and changes in arrangement of muscle cells in their walls. The authors conclude that future continuation of the research efforts in this area is necessary and will be able to provide not only novel fundamental knowledge on the biology of lymphatic aging, but also will create solid foundation for the subsequent developments of lymphatic-oriented therapeutic interventions in many diseases of the elderly.T he major task of the lymphatic system is lymph transport. This system of initial capillaries, transporting vessels, and nodes is designed to transport fluid, soluble molecules, and immune cells from the interstitium through the lymph nodes to the central veins. This system also provides the transportation route for inflammatory mediators, the products of tissue injury/destruction, foreign substances, and tumor cells. Dysfunctional lymph transport can result in a wide range of disturbances, including edema, altered immune cell trafficking, depressed immune function, and impaired lipid metabolism. The lack of knowledge on how aging affects lymphatic vessels certainly contributes to the situation when researchers and clinicians ignore lymph transport-related components of various diseases. Thus, investigation of the mechanisms affecting lymphatic contractile function during aging are extremely important for ongoing attempts to better understand the lymphatic system and to discover the pathogenesis and effective treatment of various aging-associated disorders.Until recently, there were no published reports on systematic studies on aging-associated changes in the active lymph pumps. Due to the profound difficulty of measuring lymph flow in vivo, there are only a few reports demonstrating the measurements of reduced lymph flow in aged animals. [1][2][3] In particular, it was reported 3 that aging significantly decreases lymph flow from the main mesenteric lymph duct by *60% between ages of 3 and 22 mo in rats.During the last years, we obtained important functional and molecular evidence of the aging-associated alterations of contractility in lymphatic vessels, which already widened our knowledge on the biology of aged lymph flow. On the other hand, our recent studies raise new important questions that may link several diseases to impaired coordination between lymphatic function and function of other systems in the aged body. While this review provides some recent answers on current questions in biology of lymphatic aging,...

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Section: Aged Lymphatic Contractilitymentioning

confidence: 99%

Section: Aged Lymphatic Contractilitymentioning

confidence: 99%

Aged Lymphatic Contractility: Recent Answers and New Questions

Gashev

Chatterjee

2013

Lymphatic Research and Biology

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“…Nevertheless, the pronounced age-related decrease in T-cell functions is evident, specially in the T-cell helper, which affects humoral immunity and causes an impaired B-cell function (2,7) . In the cells of innate immunity, the phagocytic cells show functions that decrease with ageing and others that are over activated (2,(11)(12)(13) , whereas the anti-tumoral activity of natural killer (NK) cells, in most of the work, shows an age-related decrease (2,11,14) . In addition, it has been demonstrated that the competence of the immune system is an excellent marker of health (2,4,8,15,16) and several age-related changes in immune functions, such as low T-cell proliferative responses, IL-2 secretion and NK cell cytotoxicity, have been linked to longevity (2,15,16) .…”

Section: Proceedings Of the Nutrition Societymentioning

confidence: 99%

Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants

Fuente

2010

Proc. Nutr. Soc.

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Several immune functions are markers of health, biological age and predictors of longevity. A chronic oxidative and inflammatory state is the main cause of ageing and the immune system is involved in the rate of ageing. Thus, several murine models of premature ageing have been proposed owing to their early immunosenescence and oxidative stress, such as ovariectomised rats and mice, obese rats and anxious mice. In the last model, the most extensively studied by us, mice showing anxiety have an aged immune function and redox status as well as a shorter longevity in comparison with animals without anxiety of the same chronological age, being denominated prematurely ageing mice. A confirmation of the above is that the administration of diets supplemented with antioxidants improves the redox status and immune functions and increases the longevity of prematurely ageing mice. Antioxidant precursors of glutathione such as thioproline or N-acetylcysteine, which have a relevant role in ageing, have been the most widely investigated in adult prematurely ageing mice in our laboratory. In the present work, we have studied the effects of the ingestion for 5 weeks of a diet supplemented with 0 . 1 % (w/w) thioproline + N-acetylcysteine on several functions of leucocytes from chronological old (69-73 weeks of age) prematurely ageing mice of two strains (Swiss and BALB/c). The results show an improvement of the immune functions, with their values becoming closer to those in adult animals (24°2 weeks). Thus, an adequate nutrition with antioxidants, even in aged subjects, could be a good strategy to retard ageing.

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“…At least partly as a consequence, older populations experience increased morbidity and premature mortality, for example, from respiratory tract pathogens (Jartti et al 2011), an increase in gastrointestinal infections , and diminished antigenspecific responses to orally administered vaccines (Grubeck-Loebenstein et al 2009;Hagiwara et al 2003). Major age-related phenotypic and functional changes to the T-cell arm of adaptive immunity occur, while B-cell function (Frasca et al 2008) and the innate immune system (Solana et al 2006) may be less markedly affected.…”

Section: Introductionmentioning

confidence: 99%