Aging and hypertension

Fukutomi, Motoki; Kario, Kazuomi

doi:10.1586/erc.10.78

Cited by 25 publications

(10 citation statements)

References 72 publications

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“…Age is a powerful risk factor for the development of hypertension 28 . Management of age-associated hypertension may be a key issue in the prevention of cardiovascular events 29 . Gender differences have been shown in the management of hypertension 30 .…”

Section: Discussionmentioning

confidence: 99%

Awareness, treatment and control of hypertension among hypertensive patients aged 18 to 59 years old in the northeast of China

Niu

et al. 2018

Sci Rep

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Hypertension not only has a high prevalence, but also brings disease burden to the affected patients. To assess the level of awareness, treatment and control of hypertension in the northeast of China, we investigated the rates of awareness, treatment and control of hypertension and identified its related factors among hypertensive patients aged 18 to 59 years old in Jilin, China. The data (n = 4632) for the present study were extracted from a cross-sectional study in Jilin. Among individuals with hypertension, the standardized rates of awareness, treatment and control of hypertension were 44.9%, 36.5%, 24.3%, respectively. The rates of awareness and treatment of hypertension among middle aged patients were higher than those among young patients. Compared to patients with normal Body Mass index (BMI), obese hypertensive patients had a higher rate of treatment (43.7% vs. 25.9%) and a lower rate of control (18.9% vs. 29.6%). Compared to patients with normal BMI, patients who were obese were more likely to take measures to treat hypertension (OR = 2.50, 95%CI: 2.05–3.05); but were less likely to have well-controlled blood pressure (OR = 0.55, 95%CI: 0.40–0.78). BMI is one of the influencing factors of hypertension awareness, treatment and control among patients 18 to 59 years old with hypertension.

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Section: Discussionmentioning

confidence: 99%

Awareness, treatment and control of hypertension among hypertensive patients aged 18 to 59 years old in the northeast of China

Niu

et al. 2018

Sci Rep

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“…Increasing age is a risk factor for hypertension, 39 preeclampsia, 40 and CVD 41 To assess whether the pregnancy-induced cardiac hypertrophy in Corin KO mice also worsens with age, we performed similar experiments in mice mated at 6 months of age. Compared to age-matched virgin Corin KO controls, Corin KO mice had a 20 ± 3% increase in HW/TL at GD18.5 (7.08 ± 0.20 vs. 8.51 ± 0.28 mg/mm, P=0.0003; Fig.…”

Section: Resultsmentioning

confidence: 99%

“…This is consistent with increased incidence of CVD, preeclampsia, and peripartum cardiomyopathy in older pregnant women. 39–41, 51 This is particularly relevant as the average age of pregnancy continues to rise. 52 We also showed that Corin KO mice had increased HW/TL and CD that persisted at least 28 days postpartum.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia

Baird

Wang

et al. 2019

Canadian Journal of Cardiology

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Background: Preeclampsia increases the risk of heart disease. Defects in the protease corin, including the variant T555I/Q568P found in ~12% of blacks, have been associated with preeclampsia and cardiac hypertrophy. The objective of this study is to investigate the role of corin and the T555I/Q568P variant in preeclampsia-associated cardiac alterations using genetically modified mouse models. Methods: Virgin wild-type (WT) and corin knockout mice with or without a cardiac WT corin or T555I/Q568P variant transgene were mated at 3 or 6 months of age. Age- and genotype-matched virgin mice were used as controls. Cardiac morphology and function were assessed at gestational day 18.5 or 28 days postpartum by histological and echocardiographic analyses. Results: Pregnant corin knockout mice at gestational day 18.5 developed cardiac hypertrophy. Such a pregnancy-associated phenotype was not found in WT or corin knockout mice with a cardiac WT corin transgene. Pregnant corin knockout mice with a cardiac T555I/Q568P variant transgene developed cardiac hypertrophy similar to that in pregnant corin knockout mice. The cardiac hypertrophy persisted postpartum in corin knockout mice and was worse if the mice were mated at 6 instead of 3 months of age. There was no hypertrophy-associated decrease in cardiac function in pregnant corin knockout mice. Conclusions: In mice, corin deficiency causes cardiac hypertrophy during pregnancy. Replacement of cardiac WT corin, but not the T555I/Q568P variant found in blacks, rescues this phenotype, indicating a local anti-hypertrophic function of corin in the heart. Corin deficiency may represent an underlying mechanism in preeclampsia-associated cardiomyopathies.

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“…These ageassociated systemic changes strongly contribute to BP elevation. In addition, advanced aging of the cardiovascular system presents a varied phenotype in older adult hypertension (see "Vascular Diseases of Aging," "Cardiovascular Response," Cardiovascular System," "Hypertensive Cardiovascular Diseases"), such as nocturnal hypertension, white coat hypertension, and morning hypertension (Fukutomi and Kario 2010).…”

Section: Advanced Agesmentioning

confidence: 99%

Hypertension

Ding¹,

Luo²,

Huang³

2020

Encyclopedia of Gerontology and Population Aging

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Arterial hypertension; High blood pressure Definition Hypertension is usually diagnosed when a person's systolic blood pressure (SBP) in the office or clinic is 140 mmHg and/or their diastolic blood pressure (DBP) is 90 mmHg following repeated examinations (Williams et al. 2018; Unger et al. 2020). This is based on the evidence from multiple randomized controlled trials (RCTs) that treatment of patients with these blood pressure (BP) values is beneficial. The same definition is used in young, middle-aged, and older people, whereas BP centiles are used in children and teenagers, in whom data from interventional trials are not available (Williams et al. 2018). BP measurement is the fundamental means and method of evaluating BP level, diagnosing hypertension, and observing antihypertensive efficacy. Clinic and out-of-office BP measurements are adopted frequently in clinical

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Aging and hypertension

Cited by 25 publications

References 72 publications

Awareness, treatment and control of hypertension among hypertensive patients aged 18 to 59 years old in the northeast of China

Awareness, treatment and control of hypertension among hypertensive patients aged 18 to 59 years old in the northeast of China

Pregnancy-Associated Cardiac Hypertrophy in Corin-Deficient Mice: Observations in a Transgenic Model of Preeclampsia

Hypertension

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