Aging and epigenetics: Longitudinal changes in gene-specific DNA methylation

Madrigano, Jaime; Baccarelli, Andrea; Mittleman, Murray A.; Sparrow, David; Vokonas, Pantel; Tarantini, Letizia; Schwartz, Joel

doi:10.4161/epi.7.1.18749

Cited by 100 publications

(91 citation statements)

References 32 publications

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“…Importantly though, statistical adjustment for this did not alter the association between LINE-1 and Alu methylation levels and individual characteristics (age, gender, smoking habits, alcohol intake, and body mass index). Candidate gene studies of methylation have reached similar conclusions [15,16]. This could mean that leukocyte populations contribute a negligible amount of variance relative to the specified model factors.…”

Section: The Epidemiological Toolkitmentioning

confidence: 80%

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Barrett

Wong

et al. 2012

Genome Biol

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Section: The Epidemiological Toolkitmentioning

confidence: 80%

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Barrett

Wong

et al. 2012

Genome Biol

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“…Yaşlanma ve DNA metilasyonu arasındaki ilişki ilk kez somon balığında yapılan çalışmalarda öne sü-rülmüştür. 31 Somon balığında yaşlanmayla birlikte global DNA metilasyon düzeyinde azalma bildirilmiştir. Bunu takiben fare, hamster, inek ve insanlarda yapılan araştırmalarda, yaşlanma sırasında özellikle tekrarlayan dizilerde global DNA metilasyon düzeyinde azalma olduğu gösterilmiştir.…”

Section: Dna Meti̇lasyon Deği̇şi̇mleri̇ Ve Yaşlanmaunclassified

Epigenetic Alterations in Aging and Aging-Associated Diseases: Review

Güneş¹,

Bayramov²

2016

Turkiye Klinikleri J Med Sci

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“…There is a loss of global DNA methylation with age (74,75) and this is reflected in a fall in methylation in some repeat elements (75)(76)(77) but not all (77) . There are also reports of increases in CpG island methylation, and decreases in methylation in regions out with CpG islands, with age in solid tissues and blood-derived DNA (78) The picture in relation to individual genes is complicated (79) , with some increasing (75,80,81) and others decreasing (76) with age.…”

Section: Epigeneticsmentioning

confidence: 99%

Epigenetic consequences of a changing human diet

Haggarty

2013

Proc. Nutr. Soc.

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The human diet has undergone profound changes over recent generations and this trend is likely to accelerate in the 21st century. Innovations in food technology, new ways of producing and processing foods and the increasing use of artificial vitamins and novel ingredients are changing the human diet in ways that our dietary monitoring systems struggle to keep pace with. There is a growing awareness of the importance of diet, but little understanding of how these changes may affect the health of current and future generations. Epigenetic programming, and specifically the persistence of functional epigenetic states following nutritional exposure, is particularly relevant to the issue of dietary change. Epigenetics is emerging as perhaps the most important mechanism through which diet and nutrition can directly influence the genome and there is now considerable evidence for nutritional epigenetic programming of health and the response to diet itself. A number of nutrients and food components that are changing in the human diet have been shown to produce epigenetic states that are stable across different timescales. We need to better understand the nutritional programming of epigenetic states, the persistence of these marks in time and their effect on biological function and the response to diet.

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Aging and epigenetics: Longitudinal changes in gene-specific DNA methylation

Cited by 100 publications

References 32 publications

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

The role of longitudinal cohort studies in epigenetic epidemiology: challenges and opportunities

Epigenetic Alterations in Aging and Aging-Associated Diseases: Review

Epigenetic consequences of a changing human diet

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