Aging and Diabetes Increase the Aggregating Potency of Rat Skin Collagen Towards Normal Platelets

Grigorova-Borsos, Anne-Marie; Bara, L.; Aberer, Elisabeth; Grochulski, A; André, Jocelyne; Mozère, G; Peyroux, J.; Sternberg, M.

doi:10.1055/s-0038-1647638

Cited by 9 publications

(2 citation statements)

References 8 publications

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“…With endothelial injury, collagen is exposed, promoting the adherence of platelets to the injured endothelium. Platelet adherence to the endothelium is enhanced in aged subjects [28, 29]. Additionally, the release of alpha‐granules, which contain TGF‐β, TGF‐α, and platelet‐derived growth factor (PDGF), by platelets increases with age [30].…”

Section: Alterations In Hemostasis and Inflammationmentioning

confidence: 99%

Aging and Wound Healing

2004

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Impaired wound healing in the elderly presents a major clinical and economic problem. With the aging population growing in both number and percentage, the importance of understanding the mechanisms underlying age-related impairments in healing is increased. Normal skin exhibits characteristic changes with age that have implications for wound healing. Additionally, the process of wound healing is altered in aged individuals. Although historically healing in the aged was considered defective, there is now consensus that healing in the elderly is delayed but the final result is qualitatively similar to that in young subjects.

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Section: Alterations In Hemostasis and Inflammationmentioning

confidence: 99%

Aging and Wound Healing

2004

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“…In vivo studies have found that aged individuals display an increase in protein aggregation compared with younger ones. 37,38 Additionally, the release of signaling molecules PDGF, TGF-a, and TGF-b is increased with age as well. 38 Inflammation.…”

Section: Structure Of the Skin How It Differs With Agementioning

confidence: 99%

Impaired Neovascularization in Aging

Bonham

Kuehlmann

Gurtner

2020

Advances in Wound Care

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The skin undergoes an inevitable degeneration as an individual ages. As intrinsic and extrinsic factors degrade the structural integrity of the skin, it experiences a critical loss of function and homeostatic stability. Thus, aged skin becomes increasingly susceptible to injury and displays a prolonged healing process. Recent Advances: Several studies have found significant differences during wound healing between younger and older individuals. The hypoxia-inducible factor 1-alpha (HIF-1a) signaling pathway has recently been identified as a major player in wound healing. Hypoxia-inducible factors (HIFs) are pleiotropic key regulators of oxygen homeostasis. HIF-1a is essential to neovascularization through its regulation of cytokines, such as SDF-1a (stromal cell-derived factor 1alpha) and has been shown to upregulate the expression of genes important for a hypoxic response. Prolyl hydroxylase domain proteins (PHDs) and factor inhibiting HIF effectively block HIF-1a signaling in normoxia through hydroxylation, preventing the signaling cascade from activating, leading to impaired tissue survival. Critical Issues: Aged wounds are a major clinical burden, resisting modern treatment and costing millions in health care each year. At the molecular level, aging has been shown to interfere with PHD regulation, which in turn prevents HIF-1a from activating gene expression, ultimately leading to impaired healing. Other studies have identified loss of function in cells during aging, impeding processes such as angiogenesis. Future Directions: An improved understanding of the regulation of molecular mediators, such as HIF-1a and PHD, will allow for manipulation of the various factors underlying delayed wound healing in the aged. The findings highlighted in this may facilitate the development of potential therapeutic approaches involved in the alteration of cellular dynamics and aging.

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Impaired Wound Repair and Delayed Angiogenesis

Ranzer

DiPietro

2010

Textbook of Aging Skin

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Aging and Diabetes Increase the Aggregating Potency of Rat Skin Collagen Towards Normal Platelets

Cited by 9 publications

References 8 publications

Aging and Wound Healing

Aging and Wound Healing

Impaired Neovascularization in Aging

Impaired Wound Repair and Delayed Angiogenesis

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