Aging and cancer epigenetics: Where do the paths fork?

Pérez, Raúl Fernández; Tejedor, Juan Ramón; Fernández, Agustín F.; Fraga, Mario F.

doi:10.1111/acel.13709

Cited by 18 publications

(12 citation statements)

References 121 publications

(155 reference statements)

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“…On the basis of biological alterations, aging can be classified into physiological and pathological aging [ 12 ] . The latter is often associated with diabetes [ 13 ] , cardiovascular diseases [ 14 ] , cancers [ 15 ] , and neuro-degenerative diseases [ 16 ] , resulting in poor life quality and, ultimately, a shortened lifespan.…”

Section: Biological or Clinical Perspectives To Define And Characteri...mentioning

confidence: 99%

Gut microbiota: an ideal biomarker and intervention strategy for aging

Xu,

Wei

et al. 2024

Microbiome Res Rep

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Population aging is a substantial challenge for the global sanitation framework. Unhealthy aging tends to be accompanied by chronic diseases such as cardiovascular disease, diabetes, and cancer, which undermine the welfare of the elderly. Based on the fact that aging is inevitable but retarding aging is attainable, flexible aging characterization and efficient anti-aging become imperative for healthy aging. The gut microbiome, as the most dynamic component interacting with the organism, can affect the aging process through its own structure and metabolites, thus holding the potential to become both an ideal aging-related biomarker and an intervention strategy. This review summarizes the value of applying gut microbiota as aging-related microbial biomarkers in diagnosing aging state and monitoring the effect of anti-aging interventions, ultimately pointing to the future prospects of microbial intervention strategies in maintaining healthy aging.

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Section: Biological or Clinical Perspectives To Define And Characteri...mentioning

confidence: 99%

Gut microbiota: an ideal biomarker and intervention strategy for aging

Xu,

Wei

et al. 2024

Microbiome Res Rep

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“…Age has complex effects on cancer development, including changes in the immune system that can promote tumor growth [ 63 , 64 , 65 , 66 , 67 ]. As we age, intrinsic anticancer activity becomes less effective and tumor-promoting functions develop.…”

Section: The Impact Of Age-related Immunosenescence On Cancer Develop...mentioning

confidence: 99%

Inflammation, Infiltration, and Evasion—Tumor Promotion in the Aging Breast

Cruz-Reyes

Radisky

2023

Cancers

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Breast cancer is a significant cause of morbidity and mortality in women, with over two million new cases reported worldwide each year, the majority of which occur in post-menopausal women. Despite advances in early detection and treatment, approximately one-third of patients diagnosed with breast cancer will develop metastatic disease. The pathogenesis and progression of breast cancer are influenced by a variety of biological and social risk factors, including age, ethnicity, pregnancy status, diet, and genomic alterations. Recent advancements in breast cancer research have focused on harnessing the power of the patient’s adaptive and innate immune systems for diagnostic and therapeutic purposes. The breast immune microenvironment plays a critical role in regulating tissue homeostasis and resistance to tumorigenesis. In this review, we explore the dynamic changes in the breast immune microenvironment that occur with age, how these changes impact breast cancer development and progression, and how targeted therapeutic interventions that leverage the immune system can be used to improve patient outcomes. Our review emphasizes the importance of understanding the complex interplay between aging, the immune system, and breast cancer, and highlights the potential of immune-based therapies in the fight against this devastating disease.

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“…Because of these attributes, aging has been identified as a risk factor for numerous diseases (3). Some common age-associated diseases include degenerative diseases of the nervous system, cardiovascular disease, cancer, immune system disease, and musculoskeletal disorders (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Aging increases the susceptibility of individuals to these different diseases and infections due to "immunosenescence," an age-related deterioration of both the innate and adaptive immune system (15).…”

Section: Introductionmentioning

confidence: 99%

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses

Talley,

Nguyen,

Van Ye

et al. 2024

Preprint

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Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome. However, most studies to date have examined changes in the transcriptomes that are associated with aging and inflammaging, despite the fact that inflammasome activation is driven by a series of post-translational activation steps, culminating in the cleavage and activation of caspase-1. Here, we utilized transgenic mice expressing a caspase-1 biosensor to examine age-associated inflammasome activation in various organs and tissues to define these post-translational manifestations of inflammaging. Consistent with other studies, we observe increased inflammation, including inflammasome activation, in tissues. However, we note that the degree of inflammasome activation is not uniformly correlated with transcriptional changes commonly used as a surrogate for inflammasome activation in tissues. Furthermore, we used a skull thinning technique to monitor central nervous system inflammasome activationin vivoin aged mice and found that neuroinflammation is significantly amplified in aged mice in response to endotoxin challenge. Together, these data reveal that inflammaging is associated with both transcriptional and post-translational inflammatory pathways that are not uniform between tissues and establish new methodologies for measuring age-associated inflammasome activationin vivoandex vivo.

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Aging and cancer epigenetics: Where do the paths fork?

Cited by 18 publications

References 121 publications

Gut microbiota: an ideal biomarker and intervention strategy for aging

Gut microbiota: an ideal biomarker and intervention strategy for aging

Inflammation, Infiltration, and Evasion—Tumor Promotion in the Aging Breast

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses

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