Aging and Calcification of the Human Coronary Artery

Nonatheromatous Peripheral Vascular Disease of the Lower Extremity in Diabetes Mellitus

“…However, as we have recently pointed out, 22 certain reservations are in order with respect to such a conclusion. In a series of studies dealing with vessels in a number of anatomic sites, Blumenthal and co-workers 23 " 26 have been unable to demonstrate any increase in the intensity of arteriosclerosis of major arteries in diabetic patients when the factors of age and coexistent hypertension were properly assessed in the comparison. Studies by Wilens 27 and by Dible 28 also support the latter conclusion.…”

Warfarin Causes Rapid Calcification of the Elastic Lamellae in Rat Arteries and Heart Valves

“…This hypothesis is supported by studies showing that the elastic lamellae are the first sites of arterial calcification in humans and that the accumulation of calcification within these elastic lamellae begins by the second decade of life and increases progressively with age. [27][28][29][30][31][32] Elastin has also been shown to be a potent and reproducible initiator of calcification in vitro. [33][34][35][36][37][38][39] In vitro calcification of elastin occurs in serum and neutral buffered solutions at physiological concentrations of calcium and phosphate.…”

Vitamin D-induced coronary atherosclerosis in normolipemic swine: Comparison with human disease.

“…atherosclerosis; coronary artery; vitamin D; calcification A crucial step in studying the pathogenesis of human coronary atherosclerosis involves the duplication of lesions which resemble those of man. In coronary atherosclerosis in man, Lansing et al (1948) …”