1988
DOI: 10.1111/j.1532-5415.1988.tb01810.x
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Aging, Alcohol, and the Liver

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Cited by 26 publications
(4 citation statements)
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“…This may have to do with the fact that the effects of alcohol at the cellular and organ levels are altered by physiological changes associated with aging. In particular, while the absorption of alcohol is equally rapid among all age groups (Scott & Mitchell, 1988), a decrease in lean tissue and water with a relative increase in fatty tissue in older age, may account for reduced tolerance to alcohol. Accordingly, a given amount of alcohol is distributed in a smaller volume, resulting in increased alcohol concentration with any given dose of alcohol (Smith, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…This may have to do with the fact that the effects of alcohol at the cellular and organ levels are altered by physiological changes associated with aging. In particular, while the absorption of alcohol is equally rapid among all age groups (Scott & Mitchell, 1988), a decrease in lean tissue and water with a relative increase in fatty tissue in older age, may account for reduced tolerance to alcohol. Accordingly, a given amount of alcohol is distributed in a smaller volume, resulting in increased alcohol concentration with any given dose of alcohol (Smith, 1995).…”
Section: Discussionmentioning
confidence: 99%
“…This is partly because the loss of lean body mass related to ageing can reduce the volume of alcohol distribution, resulting in an increased peak ethanol concentration with any given dose of alcohol [6, 7]. The activity of the enzyme alcohol dehydrogenase, which breaks down alcohol is also significantly reduced in older adults [8], potentially increasing the amount of ethanol that reaches the bloodstream.…”
Section: Introductionmentioning
confidence: 99%
“…Several of the drugs most commonly used by older people have strong potential for adverse interactions with alcohol 14 . Psychotropic drugs, especially sedative hypnotics, are among the most commonly prescribed types of medication 2,15–17 .…”
mentioning
confidence: 99%