Aging Affects the Efficacy of Platelet-Rich Plasma Treatment for Osteoarthritis

Chowdhary, K. R.; Sahu, Amrita; Iijima, Hirotaka; Shinde, Sunita; Borg‐Stein, Joanne; Ambrosio, Fabrisia

doi:10.1097/phm.0000000000002161

Cited by 3 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The efficacy of PCs is impacted not only by the previously mentioned preparation methods, but also by the age and underlying health conditions of the donors 39 , 40 . Scholars conducted a study using a rat model of myocardial infarction, in which they observed that the application of PRP derived from young donors in combination with BMSCs led to a reduction in the infarct area.…”

Section: Factors Influencing the Efficacy Of The Relevant Treatment A...mentioning

confidence: 99%

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Li,

Xiao,

Wang

et al. 2024

Cell Transplant

View full text Add to dashboard Cite

This article presents a comprehensive review of the factors influencing the efficacy of mesenchymal stem cells (MSCs) transplantation and its association with platelet concentrates (PCs). It focuses on investigating the impact of PCs’ composition, the age and health status of platelet donors, application methods, and environmental factors on the outcomes of relevant treatments. In addition, it delves into the strategies and mechanisms for optimizing MSCs transplantation with PCs, encompassing preconditioning and combined therapies. Furthermore, it provides an in-depth exploration of the signaling pathways and proteomic characteristics associated with preconditioning and emphasizes the efficacy and specific effects of combined therapy. The article also introduces the latest advancements in the application of biomaterials for optimizing regenerative medical strategies, stimulating scholarly discourse on this subject. Through this comprehensive review, the primary goal is to facilitate a more profound comprehension of the factors influencing treatment outcomes, as well as the strategies and mechanisms for optimizing MSCs transplantation and the application of biomaterials in regenerative medicine, offering theoretical guidance and practical references for related research and clinical practice.

show abstract

Section: Factors Influencing the Efficacy Of The Relevant Treatment A...mentioning

confidence: 99%

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Li,

Xiao,

Wang

et al. 2024

Cell Transplant

View full text Add to dashboard Cite

show abstract

“…Recognising that older patients may experience a slower healing response underscores the importance of age as a patient-specific factor. This consideration informs clinicians about potential variations in treatment outcomes, allowing for adjustments in treatment plans and setting realistic expectations based on the patient's age-related healing dynamics [ 31 ].…”

Section: Reviewmentioning

confidence: 99%

A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing

Gharpinde,

Pundkar,

Shrivastava

et al. 2024

Cureus

View full text Add to dashboard Cite

This comprehensive review delves into the emerging role of platelet-rich plasma (PRP) in accelerating bone healing. PRP, a blood-derived product rich in platelets and growth factors, has garnered attention for its regenerative potential. The review begins by defining PRP and providing a historical background, highlighting its significance in expediting bone healing. PRP's composition and preparation methods, including centrifugation techniques and commercial kits, are explored. Mechanistically, PRP operates by releasing growth factors, chemotaxis, and angiogenesis, elucidating its cellular effects. Applications in fracture healing and orthopaedic surgeries, such as joint arthroplasty and spinal fusion, are discussed, emphasising the promising outcomes in clinical trials. Safety considerations, patient selection criteria, and the need for PRP preparation and application standardisation are underscored. The review outlines ongoing research trends, potential technological advancements, and unexplored areas in paediatric applications and inflammatory bone disorders. The implications for clinical practice involve informed decision-making, optimised protocols, and interdisciplinary collaboration. In conclusion, the future of PRP in bone healing holds exciting prospects, with the potential for precision medicine, integration with emerging therapies, expanded applications, and enhanced technological innovations shaping its trajectory in orthopaedics and regenerative medicine.

show abstract

Women show a positive response to platelet‐rich plasma despite presenting more painful knee osteoarthritis than men

Sánchez,

Jorquera,

López de Dicastillo

et al. 2024

Knee surg. sports traumatol. arthrosc.

View full text Add to dashboard Cite

PurposeThe purpose of this study was to evaluate the impact of gender on the efficacy of platelet‐rich plasma (PRP) in patients with knee osteoarthritis (KOA), comparing their short‐term response between men and women.MethodsFour hundred‐eighteen patients (529 knees) were included. Patients were treated with three injections of PRP on a weekly basis. Blood and PRP samples were randomly tested. Patients were asked to complete the knee injury and osteoarthritis outcome score (KOOS) and 12‐item short form survey (SF‐12), at baseline and 6 months. Success rates were calculated according to a reduction in the pain score of at least 9.3 points [minimal clinically important improvement (MCII)]. Comparative tests and multivariate regression were performed.ResultsThe PRP had a platelet concentration factor of 2.0X compared to blood levels, with no leucocytes or erythrocytes. KOOS scores showed an increase from baseline to 6 months (p < 0.0001). There was an increase in the physical component summary (PCS) (p < 0.0001) and mental component summary (MCS) (p < 0.01) of the SF‐12. The number of knees of women with MCII was 156 out of 262 (59.6%), whereas the number of knees of men was 136 out of 267 (50.9%) (p = 0.0468). Women had worse baseline scores on pain (p = 0.009), PCS (p < 0.0001) and MCS (p < 0.0001).ConclusionAlthough the symptomatology generated by KOA was worse in women when compared to men, treatment with repeated injections of PRP was effective, ultimately achieving a higher improvement in women providing comparable final follow‐up outcomes between men and women.Level of EvidenceLevel IV

show abstract

Aging Affects the Efficacy of Platelet-Rich Plasma Treatment for Osteoarthritis

Cited by 3 publications

References 30 publications

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications

A Comprehensive Review of Platelet-Rich Plasma and Its Emerging Role in Accelerating Bone Healing

Women show a positive response to platelet‐rich plasma despite presenting more painful knee osteoarthritis than men

Contact Info

Product

Resources

About