Aging — A Few Biological And Chemical Considerations

Friedman, Joseph Joel

doi:10.1016/s0033-3182(66)72087-8

Psychosomatics

1966

DOI: 10.1016/s0033-3182(66)72087-8

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Aging — A Few Biological And Chemical Considerations

Joseph Joel Friedman

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1971

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“…However, an increased rate of protein synthesis has also been proposed, based on the theory that this might be necessary to compensate for inactive enzymes (10). Friedman (11) finds no real, direct evidence that structural protein deteriorates with age but points out that connective tissue increases with age.…”

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The Geriatric Patient: Age‐dependent Physiologic and Pathologic Changes

Lamy

Kitler

1971

J American Geriatrics Society

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Age-dependent physiologic and pathologic changes are discussed under the categories of the soft tissues, the eardlovascular, digestive, respiratory, skeletal and nervous systems, the genito-urinary tract, the senses, speech, hearing, visual function, and the nutritional state.Aging does not affect the whole organism uniformly; rather, it involves the various organs and organ systems to different degrees and in different fashions. Many ideas have been advanced in an effort to explain the process of aging. It has been viewed simply as a decline in free energy with time, i.e., the energy which is needed by the cell to perform its variojjs functions ( 1). As a consequence of aging, there is a decline in the efficiency of physiologic regulation (2); thus the organism is less resistant to stress than is a younger one. The activities of several enzymes decrease with age, due either to a decrease in the rate of synthesis or a change in enzyme structure (3, 4). Other changes with age are: major structural damage to chromosomes (5), accumulation of organic matter in the soft tissues (6), and an accelerated rate of accumulation of gamma globulin with an accelerated rate of decrease of other serum globulin fractions (7).Aging has also been described as a normal part of the life cycle, an intrinsic process which is genetically determined (8). This may well be based on inborn metabolic defects which could be the basic reason for the physiologic changes observed with aging (9). It has been proposed that certain regions of the DNA molecule may not be accessible for transcription, which in turn could cause decreased protein synthesis. However, an increased rate of protein synthesis has also been proposed, based on the theory that this might be necessary to compensate for inactive enzymes (10). Friedman (11) finds no real, direct evidence that structural protein deteriorates with age but points out that connective tissue increases with age.The process of aging has also been summarized as a gradual loss of functional cells and a gradual impairment of the biochemical processes in those cells which do remain functional (12). Birren (13) attributes the aging

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confidence: 99%

The Geriatric Patient: Age‐dependent Physiologic and Pathologic Changes

Lamy

Kitler

1971

J American Geriatrics Society

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Aging — A Few Biological And Chemical Considerations

Cited by 1 publication

References 8 publications

The Geriatric Patient: Age‐dependent Physiologic and Pathologic Changes

The Geriatric Patient: Age‐dependent Physiologic and Pathologic Changes

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