Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy

Herrerias, Juan Manuel; Leighton, Jonathan A.; Costamagna, Guido; Infantolino, Anthony; Eliakim, Rami; Fischer, Doron; Rubin, David T.; Manten, Howard D.; Scapa, Eitan; Morgan, Douglas R.; Bergwerk, Ari; Koslowsky, Binyamin; Adler, Samuel N.

doi:10.1016/j.gie.2007.10.063

Cited by 191 publications

(143 citation statements)

References 12 publications

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“…This capsule is identical to the video capsule, with the same dimensions, and is made of lactulose and 5% barium, which make the capsule radiopaque and it dissolves spontaneously after 40 h. The capsule has a radiofrequency identification tag that enables easy detection by a special handheld device. In a recent study that included patients with known strictures, no CE retention occurred if the patency capsule passed safely [65] . Although there are promising data on patency capsule use before CE, it is still not definitive to predict capsule retention based on results of barium studies or patency capsule.…”

Section: Complications Limitations and Safety Issues Of Capsule Endomentioning

confidence: 98%

Five years’ experience with capsule endoscopy in a single center

Kav¹,

Bayraktar²

2009

WJG

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Capsule endoscopy (CE) is a novel technology that facilitates highly effective and noninvasive imaging of the small bowel. Although its efficacy in the evaluation of obscure gastrointestinal bleeding (OGIB) has been proven in several trials, data on uses of CE in different small bowel diseases are rapidly accumulating in the literature, and it has been found to be superior to alternative diagnostic tools in a range of such diseases. Based on literature evidence, CE is recommended as a first-line investigation for OGIB after negative bidirectional endoscopy. CE has gained an important role in the diagnosis and follow-up of Crohn's disease and celiac disease and in the surveillance of small bowel tumors and polyps in selected patients. Capsule retention is the major complication, with a frequency of 1%-2%. The purpose of this review was to discuss the procedure, indications, contraindications and adverse effects associated with CE. We also review and share our five-year experience with CE in various small bowel diseases. The recently developed balloon-assisted enteroscopies have both diagnostic and therapeutic capability. At the present time, CE and balloon-assisted enteroscopies are complementary techniques in the diagnosis and management of small bowel diseases.

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Section: Complications Limitations and Safety Issues Of Capsule Endomentioning

confidence: 98%

Five years’ experience with capsule endoscopy in a single center

Kav¹,

Bayraktar²

2009

WJG

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“…In the paediatric literature there are reports of only three cases of capsule retention in strictured small bowel that did not respond to corticosteroids and required surgical intervention [108,111,115]. Use of a patency capsule can decrease the risk of capsule retention and has been used in paediatric patients with good effect [64]. Visualization of the small bowel by SBCE may be impaired by intestinal contents.…”

Section: Sbce: Safety and Prior Investigationsmentioning

confidence: 99%

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Bourreille¹,

Ignjatovic²,

Aabakken³

et al. 2009

Endoscopy

303

185

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“…With these two timer plugs, the dissolution process starts earlier (30 h), and the contact with intestinal fluids is ensured even if the device is blocked in a tight stricture [32] . The new capsule, named Agile © Patency Capsule, has been evaluated in a multicenter clinical trial [33] designed to assess its safety in patients with known strictures and its ability to help physicians identify which patients may safely undergo CE. In this study, the intestinal tract was considered to be sufficiently patent if the capsule was excreted intact, or if the capsule was not detected by the scanner at 30 h after ingestion.…”

confidence: 99%

Caunedo-Álvarez

Romero-Vázquez²,

Herrerías‐Gutiérrez³

2008

WJG

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Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency © capsule is a good tool for assessment of the functional patency of the small bowel, and it allows identification of those patients who can safely undergo a capsule endoscopy, despite clinical and radiographic evidence of small-bowel obstruction. Some cases of intestinal occlusion have been reported with the Patency © capsule, four of them needed surgery. So, a new capsule with two timer plugs (Agile © capsule) has been recently developed in order to minimize the risk of occlusion. This new device stars its dissolution process earlier (30 h after ingestion) and its two timer plugs have been designed to begin the disintegration even when the device is blocked in a tight stricture.

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Agile patency system eliminates risk of capsule retention in patients with known intestinal strictures who undergo capsule endoscopy

Cited by 191 publications

References 12 publications

Five years’ experience with capsule endoscopy in a single center

Five years’ experience with capsule endoscopy in a single center

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus

Patency© and agile© capsules

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