Aggressive variants of follicular cell-derived thyroid carcinoma: an overview

Pizzimenti, Cristina; Fiorentino, Vincenzo; Ieni, Antonio; Martini, Maurizio; Tuccari, Giovanni; Lentini, Maria; Fadda, Guido

doi:10.1007/s12020-022-03146-0

Cited by 19 publications

(19 citation statements)

References 92 publications

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“…Hobnail subtype, which was originally described as “thyroid papillary carcinoma with micropapillary and hobnail growth pattern” by our group in 2009, has similarity with histological features of micropapillary serous ovarian carcinoma 7 . The survival rates at 10 years with columnar cell and hobnail subtypes (89% and 64.1%) were worse than that of classic PTC (97%) 4 . The PTC with aggressive FFS pattern was shown to have frequent mitotic figures, necrosis, lymphovascular invasion, extrathyroidal invasion and metastases with high clinical stage.…”

Section: Discussionmentioning

confidence: 92%

“…The clustered follicular or solid patterns can be found in classic PTC and its subtypes, but predominant growth of FFS pattern with frequent mitotic figures and necrosis are not found in those PTCs. Among the subtypes of thyroid carcinomas, cribriform morular thyroid carcinoma, infiltrative follicular subtype and solid/trabecular subtype of PTC have been listed as differential diagnoses 3,4 . Cribriform morular thyroid carcinoma, which was formerly cribriform‐morular variant of PTC, shows cribriform growth pattern with morular formations.…”

Section: Discussionmentioning

confidence: 99%

“…Molecular profile of classic PTC includes BRAF V600E mutation in 90% of cases and RET/PTC fusions in 30% to 50% of cases, followed by mutation in TERT promoter, RAS and TRK 9 . Aggressive columnar cell and hobnail subtypes show slightly different molecular profiles from classic PTC 3,4,9 . Columnar cell subtype has the most common genetic mutation in BRAF V600E (approximately 30%–45%), followed by mutations in RAS , TERT promoter, TP53 , and loss of CDKN2A .…”

Section: Discussionmentioning

confidence: 99%

“…Most of these subtypes usually show an overall excellent prognosis with rare cancer death in spite of frequent nodal metastases 1 . Conversely, some of the rarer subtypes of PTCs, such as columnar and hobnail subtypes, have a poorer prognosis owing to aggressive behavior and they have been recognized as an intermediate malignancy between conventional PTC and poorly differentiated carcinoma 3,4 …”

Section: Introductionmentioning

confidence: 99%

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Papillary thyroid carcinoma with aggressive fused follicular and solid growth pattern: A unique histological subtype with high‐grade malignancy?

Murata

Matsuzaki

Kishimoto

et al. 2023

Pathology International

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Papillary thyroid carcinoma (PTC) is usually indolent; however, some rare subtypes of PTCs, such as columnar cell and hobnail subtypes, carry poor prognosis as an intermediate malignancy between differentiated carcinoma and anaplastic carcinoma. We present the case of a 56‐year‐old Japanese woman having PTC with aggressive behavior showing characteristic histological features of a predominantly fused follicular and focally solid (FFS) pattern. The fused follicular pattern is cribriform‐like without intermingled vessels. This PTC with FFS pattern included frequent mitotic figures, necrosis, lymphovascular invasion, and metastases with high clinical stage. The tumor cells were broadly positive for antibodies to TTF‐1, PAX8, and bcl‐2, and negative for cyclin D1. Ki‐67 labeling index was approximately 10%, and there was occasional positivity of p53. Targeted next generation sequencing analysis only detected a NRAS mutation (Q61K); there was no mutation and no translocation of other genes including BRAF and RET/PTC. To our knowledge, this is first report that PTC shows aggressive FFS growth pattern. The tumor is possibly included in the new category of differentiated high‐grade thyroid carcinoma in the World Health Organization 2022 classification, or in a novel subtype of PTC owing to its characteristic histological feature and intermediate malignancy between differentiated carcinoma and anaplastic carcinoma.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Papillary thyroid carcinoma with aggressive fused follicular and solid growth pattern: A unique histological subtype with high‐grade malignancy?

Murata

Matsuzaki

Kishimoto

et al. 2023

Pathology International

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“…2Center for Innovative Medical Technologies Euroonco Clinic, Moscow и прогноз, и в первую очередь следует упомянуть папиллярный рак ЩЖ. Некоторые агрессивные варианты папиллярного рака ЩЖ имеют большую тенденцию к экстраорганному росту, метастазированию и рецидивам[7]. Несмотря на описанное в мировой литературе многообразие морфологических типов АР, до сих пор остается неизвестным влияние гистологических характеристик опухоли на прогноз заболевания и общую выживаемость (ОВ) пациентов[8].…”

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