Objective: The purpose of this study was to evaluate the efficacy and the cost-benefit of preoperative Intra-aortic Balloon Pump (IABP) treatment on peri-and post-operative cardiac performance, improved hemodynamic stability, reduced mortality and morbidity and the optimal timing in high-risk patients undergoing Coronary Artery Bypass Grafting (CABG), when compared to patients who did not receive IABP therapy. Methods: Between January 2011 and June 2012, a total of 1149 patients underwent CABG at our institution of which IABP was inserted in 90 patients, out of which 30 patients satisfied the inclusion criteria. Out of 30 patients 10 had IABP insertion pre-operative, 10 had intraoperative, and 10 had post-operative period. Euro score additive and logistic were comparable in all the three groups to determine the benefit of using IABP prior to operation. Results: Inotropic support in pre-IABP group is less as compared to intra-and post-IABP group (p<0.02). The mean duration of ICU stay was more in intra-operative and post-operative IABP group (p<0.28). No hospital mortality in pre-operative IABP group (0/10), 2 patient died in intra-operative IABP group (2/10), 3 died in post-operative IABP group (3/10). Conclusions: This study demonstrated pre-operative IABP therapy is an efficient and safe supportive modality which significantly decreases the risk for hemodynamic instability in highrisk patients undergoing CABG, improved cardiac performance, reduced inotropic requirements, lower rate of hospital mortality and less post-operative morbidity, improve survival and shortens both ICU and hospital length of stay significantly and is therefore cost effective. Further studies with inclusion of more cases are required to verify our findings.