Aggressive plasmablastic lymphoma of the thoracic spine presenting as acute spinal cord compression in a case of asymptomatic undiagnosed human immunodeficiency virus infection

Harris, Elly; Butler, Joseph S.; Cassidy, Noelle

doi:10.1016/j.spinee.2013.12.018

Cited by 7 publications

(9 citation statements)

References 30 publications

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“…[13][14][15] Lastly, there have been numerous case reports regarding patients with spinal cord compressions caused by lymphoma. [16][17][18] According to a cross-sectional study by Saunders et al, the lifetime prevalence of cancer in those with spinal cord injury is 6.3%. 19 Within this study, skin cancer was the most common and was as common as "other" or "multiple" cancers at 32.1%.…”

Section: Discussionmentioning

confidence: 99%

Development of acute promyelocytic leukemia in a patient with tetraplegia while in inpatient rehabilitation: A case report

Beal

Krouse

Tubbs

2017

The Journal of Spinal Cord Medicine

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There is a wide differential for fever after a spinal cord injury. In this case report, the source of fever was APL. It is important as healthcare providers to not overlook fevers when otherwise common causes do not fit the clinical picture. Additionally, there has been no association found between traumatic spinal cord injury and the development of acute leukemia, however this is the first case report. Therefore, it is important to continue investigating to determine if an association exists.

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Section: Discussionmentioning

confidence: 99%

Development of acute promyelocytic leukemia in a patient with tetraplegia while in inpatient rehabilitation: A case report

Beal

Krouse

Tubbs

2017

The Journal of Spinal Cord Medicine

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“…It is then thought to enter the epidural space via the vertebral foramen without causing bony erosion [ 10 ]. This invasion method is likely to be unique to spinal lymphomas, in contrast to other tumors where cord invasion is achieved through vertebral bone destruction [ 11 ]. Rubinstein proposed that epidural lymphomas might arise from the epidural lymphoid rests through antigenic stimulation [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…With regard to chemotherapy and radiation, the combination of both therapies is more effective than either of them alone. Hyper-CVAD (cyclophosphamide, vincristine, doxorubicin, and dexamethasone) or CHOP regimens have shown favorable outcomes [ 11 ]. The DeAngelis protocol which consists of pre-radiation high-dose methotrexate and post-radiation cytarabine has shown favorable outcomes [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…Harris et al recommended an innovative algorithm in which primary neurosurgical intervention is pursued in the presence of severe neurological deficit or if tissue diagnosis is needed. In other cases, primary chemoradiation can be attempted, and surgical intervention can be performed in case of clinical deterioration [ 11 ]. Since our patient did not present with a disabling neurological deficit, conservative management was deemed appropriate.…”

Section: Discussionmentioning

confidence: 99%

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Primary Non-Hodgkin’s Lymphoma of the Spine: A Case Report and Literature Review

Moussaly¹,

Nazha²,

Zaarour³

et al. 2015

World J Oncol

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Primary non-Hodgkin’s lymphoma (NHL) of the spine is a rare form of extranodal lymphoma. This entity constitutes a diagnostic challenge due to its mimicking of other spinal diseases and the difficulty in establishing a tissue diagnosis. In fact, core biopsy can be inconclusive, oftentimes requiring surgical biopsy. Definitive evidence is lacking regarding the treatment of choice. As a result, the prognosis remains unfavorable. We present the case of an adult female who presented with back pain and was found to have a spinal NHL. We also review the literature regarding this rare occurrence.

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“…E. Harris и соавт. (2014) считают необходимым начинать лечение с комбинированной химиолучевой терапии, а операцию выполнять лишь при клиническом ухудшении [42].…”

Section: малоинвазивные методикиunclassified

Spinal tumors: literature review

Закондырин

Грин

2022

Nejrohirurgiâ (Mosk.)

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Problems epidemiology, classification, diagnosis, and treatment of spinal tumors are considered. Data on morbidity and characteristics of different histological forms of benign and malignant vertebral tumors are presented. Features of spinal tumor diagnosis, classic radiological signs, and current noninvasive visualization and invasive (biopsy) techniques are discussed. Literature data on techniques and capabilities of surgical treatment are analyzed. Current trends in selection of surgical intervention radicality level depending on the type of spinal tumor using staging classifications by Ennеking, Weinstein–Boriani–Biagini and Tomita are described. Current indications for radical en bloc resection performed in a limited number of cases is considered. Minimally invasive spine surgery is discussed: from vertebroplasty, radiofrequency ablation and intervention removal of metastatic tumor to separation surgery for epidural compression. Apart from surgical treatment, neoadjuvant and adjuvant radiotherapy of vertebral tumors are analyzed: conventional, conformal, including stereotaxic, beam therapy and radiosurgery. Data on current trends in treatment selection depending on histological nature of the tumor, its radiosensitivity and probability of post-radiation malignant transformation are presented. Drug treatment, in particular chemotherapy, is an indispensable in treatment of secondary and some primary spinal tumors. Data on chemosensitivity of various tumors and tactics of combination and complex treatment are presented. Evidently, the current trend is to decrease the level of surgical invasiveness and selection of minimally invasive methods of surgical treatment. Moreover, it is concluded that considering the biological nature of hemopoietic tumors and some sarcomas, currently surgical treatment is not the main method of treatment of these malignant tumors.

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Aggressive plasmablastic lymphoma of the thoracic spine presenting as acute spinal cord compression in a case of asymptomatic undiagnosed human immunodeficiency virus infection

Cited by 7 publications

References 30 publications

Development of acute promyelocytic leukemia in a patient with tetraplegia while in inpatient rehabilitation: A case report

Development of acute promyelocytic leukemia in a patient with tetraplegia while in inpatient rehabilitation: A case report

Primary Non-Hodgkin’s Lymphoma of the Spine: A Case Report and Literature Review

Spinal tumors: literature review

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