Aggressive periodontitis presents a higher degree of bilateral symmetry in comparison with chronic periodontitis

Brito, Liana Freire de; Taboza, Zuila Albuquerque; Silveira, Virgínia Régia Souza da; Furlaneto, Flávia Aparecida Chaves; Rösing, Cassiano Kuchenbecker; Rêgo, Rodrigo Otávio

doi:10.2334/josnusd.16-0669

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…While the stage depends on the severity and extent of the disease at the time of presentation, the grade provides information on biological features of the disease such as specific clinical patterns suggestive of periods of rapid progression and/or early-onset of the disease and the relationship between plaque deposits and periodontal destruction, 3,27 as previously required for the diagnosis of aggressive periodontitis. 28,29 The mean age was higher, and the mean number of teeth was smaller in Group B than in Group C. Despite the lower mean age in Group C, the mean BoP value was higher, suggesting greater disease severity. This was expected since Group C consisted of patients with destruction patterns suggestive of periods of rapid progression and early-onset of disease, especially those previously classified as having aggressive periodontitis.…”

Section: Discussionmentioning

confidence: 95%

Analysis of Porphyromonas gingivalis fimA genotypes in severe periodontitis patients

2020

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The aim of this study was to i) evaluate the prevalence of P. gingivalis and the genotypes fimA I, Ib, II, III, IV, and V in Brazilian patients with periodontitis stage III and IV, grades B and C, ii) compare periodontitis grades B and C with regard to the prevalence of P. gingivalis and fimA genotypes, and iii) correlate the presence of these pathogens with clinical periodontal variables. Two samples of subgingival biofilm were collected from the interproximal sites with the greatest clinical attachment loss (CAL) of each patient (grade B = 38; grade C = 54) and submitted to polymerase chain reaction (PCR) for the identification of P. gingivalis and fimA genotypes. The collected periodontal clinical parameters included gingival index, plaque index, probing depth (PD), bleeding on probing (BoP) and CAL. P. gingivalis was present in 61.96% of the samples, but more prevalent in patients with grade C periodontitis (p = 0.048) and higher CAL (p < 0.001), PD (p < 0.001), and BoP (p = 0.01) values, and at sites with high CAL values (p = 0.01). The fimA II genotype was more prevalent in patients with greater mean PD (p = 0.04) and a higher proportion of bleeding sites (p = 0.006). Thus, in this sample of Brazilian periodontitis patients, the presence of P. gingivalis was associated with grade C periodontitis and periodontal destruction, while the fimA II genotype was associated with increased PD and BoP, supporting the notion that P. gingivalis fimA II is an important virulence factor in periodontal tissues.

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Section: Discussionmentioning

confidence: 95%

Analysis of Porphyromonas gingivalis fimA genotypes in severe periodontitis patients

2020

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“…7,9 Baer 1 initially described arc/vertical symmetrical patterns of bone loss in permanent dentition, 1,10 which was supported by others. 11,12 However, analysis within families for symmetry and disease patterns has not been properly evaluated. The disease in primary dentition is less discussed in the literature but appears to present early onset on deciduous first molars, with progression to primary second molars.…”

Section: Introductionmentioning

confidence: 99%

“…Up to 80%–90% of C‐MIP cases in permanent dentition were reported to exhibit radiographic bone loss at the primary dentition, retrospectively, suggesting that this disease may have an early start 7,9 . Baer 1 initially described arc/vertical symmetrical patterns of bone loss in permanent dentition, 1,10 which was supported by others 11,12 . However, analysis within families for symmetry and disease patterns has not been properly evaluated.…”

Section: Introductionmentioning

confidence: 99%

Pattern of grade C molar‐incisor pattern periodontitis in families

Tabaa

Adatowovor

Shabila

et al. 2023

Journal of Periodontology

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Background The aim of this study was to determine the clinical and inflammatory response patterns for individual siblings diagnosed with grade C molar‐incisor pattern periodontitis (C‐MIP) and between the related siblings within families. Methods Sixty‐nine siblings within 28 families with moderate‐to‐severe C‐MIP were included. Clinical parameters were evaluated for symmetry regarding the affected type of teeth, side and/or arch, and bone loss pattern. The protein concentrations from in vitro whole blood cultures for 14 different lipopolysaccharide‐stimulated inflammatory markers were correlated with the extent and severity of disease, within an individual sibling and among siblings within a family. Results A similar disease pattern was observed among all siblings and within families. The most common teeth affected were first molars and incisors or first molars only within the permanent dentition and only molars within the primary dentition (p < 0.001). Symmetry involving molars was higher than in incisors in siblings, regardless of arch or side affected (p = 0.020). Arc‐shape/vertical bone defects were the most common (p = 0.006) and higher symmetry was found for these defects in the permanent dentition (p = 0.005). Positive correlations were found between age, clinical attachment loss, and percent affected sites with several inflammatory markers. The inflammatory responses for several inflammatory markers were correlated within and among families (p < 0.050). Specifically, the intraclass correlation coefficient within families was highest (>0.5) for interleukin (IL)‐8, IL‐6, and IL‐10. Conclusions Families with C‐MIP presented similar patterns of disease. The level of an inflammatory response to bacteria seemed to play a role in the extent and severity of this disease, exemplified by the high degree of correlation in these families.

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“…Additionally, pathogenic endotoxins can induce the release of large amounts of inflammatory cytokines into the local and peripheral bloodstream. Numerous studies have reported the effects of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-8, in chronic periodontitis; but the role of IL-18 in the development and progression of chronic periodontitis remains unclear (6,7).…”

Section: Introductionmentioning

confidence: 99%

IL‑18 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NF‑κB signaling

et al. 2018

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Chronic periodontitis is the most common periodontal disease and is characterized by progressive degeneration of periodontal tissue. Periodontal-specific pathogens can induce the expression of various inflammatory cytokines in periodontal ligament cells and their secretion into peripheral blood. These inflammatory cytokines have an important role in the occurrence and development of chronic periodontitis. ELISA was used to detect the expression of interleukin-18 (IL-18) protein in the serum and saliva of 30 healthy volunteers and 30 patients with chronic periodontitis. The clinical parameters that were assessed included plaque index, gingival index, periodontal probing depth and attachment loss. The effect of IL-18 on the viability of human periodontal ligament fibroblasts (hPDLFs) was examined using a Cell Counting Kit-8 assay. The effects of IL-18 on mRNA expression and secretion of matrix metalloproteinase (MMP)1, MMP2, MMP3 and MMP9 in hPDLFs were detected by reverse transcription-quantitative polymerase chain reaction and ELISA, respectively. The effect of IL-18 on the phosphorylation of nuclear factor-κB (NF-κB) p65 protein and the protein expression of MMP1, MMP2, MMP3 and MMP9 in hPDLF cells was detected by western blotting. The expression level of IL-18 in the serum of patients with chronic periodontitis was significantly higher than that of healthy volunteers, and the expression level of IL-18 in saliva was positively correlated with the periodontal destruction. However, IL-18 did not have a significant effect on the viability ability of hPDLFs. IL-18 promoted phosphorylation of NF-κB p65 protein in hPDLF, and increased the mRNA expression and protein secretion of MMP1, MMP2, MMP3 and MMP9. These findings indicate that IL-18 promotes the secretion of MMP1, MMP2, MMP3, and MMP9 in hPDLFs by activating the NF-κB signaling pathway, which has a key role in the development of chronic periodontitis. Therefore, targeting IL-18 may be a new research direction for the treatment of chronic periodontal disease.

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Aggressive periodontitis presents a higher degree of bilateral symmetry in comparison with chronic periodontitis

Cited by 4 publications

References 26 publications

Analysis of Porphyromonas gingivalis fimA genotypes in severe periodontitis patients

Analysis of Porphyromonas gingivalis fimA genotypes in severe periodontitis patients

Pattern of grade C molar‐incisor pattern periodontitis in families

IL‑18 promotes the secretion of matrix metalloproteinases in human periodontal ligament fibroblasts by activating NF‑κB signaling

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