Aggressive periodontitis in southwestern American Indian adolescents

Rams, Thomas E.; Contreras, Adolfo; Slots, Jørgen

doi:10.1002/jper.23-0410

Cited by 3 publications

(4 citation statements)

References 44 publications

(111 reference statements)

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“…Enriched Brucella blood agar comprised the nonselective culture medium, Hammond's selective medium was used for Campylobacter isolation (Rams et al, 1993b ), and TSBV agar for Aggregatibacter actinomycetemcomitans (Slots, 1982 ). Porphyromonas gingivalis, Tannerella forsythia, Campylobacter species, Fusobacterium nucleatum , Parvimonas micra, Prevotella intermedia/nigrescens , and A. actinomycetemcomitans were routinely identified using established methods (Rams & Slots, 2023 ; Rams et al, 1996 , 2016 , 2018b , 2023 ), and the percentage of each study species was calculated. Phase‐contrast microscopy enumerated the proportional distribution of spirochetes and motile rods among total subgingival morphotypes (Slots et al, 1979 ).…”

Section: Methodsmentioning

confidence: 99%

Elevated subgingival temperature infers high bacterial pathogen counts in severe periodontitis

Rams,

Slots

2024

Clinical & Exp Dental Res

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ObjectivesPeriodontal inflammation may be assessed by bleeding on probing and subgingival temperature. This pilot study evaluated the intrapatient relationship between subgingival temperature and selected bacterial groups/species in deep periodontal pockets with bleeding on probing.Materials and MethodsIn each of eight adults, an electronic temperature probe identified three “hot” pockets with elevated subgingival temperature and three “cool” pockets with normal subgingival temperature among premolars/molars with 6‒10 mm probing depths and bleeding on probing. Microbial samples collected separately from the hot and cool periodontal pockets were cultured for selected periodontal pathogens.ResultsHot compared to cool periodontal pockets revealed significantly higher absolute and normalized subgingival temperatures and yielded higher mean proportions of Porphyromonas gingivalis (10.2% for hot vs. 2.5% for cool, p = 0.030) and total red/orange complex periodontal pathogens (48.0% for hot vs. 24.6% for cool, p = 0.012).ConclusionsHot versus cool deep periodontal pockets harbored significantly higher levels of major periodontal pathogens. Subgingival temperature measurements may potentially be useful to assess risk of periodontitis progression and the efficacy of periodontal therapy.

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Section: Methodsmentioning

confidence: 99%

Elevated subgingival temperature infers high bacterial pathogen counts in severe periodontitis

Rams,

Slots

2024

Clinical & Exp Dental Res

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“…Cytomegalovirus was detected in classic localized juvenile periodontitis but not in healthy periodontal sites, and cytomegalovirus was associated with juvenile periodontitis with an odds ratio of 3.5. 18 The two main periodontopathic bacteria A. actinomycetemcomitans and P. gingivalis occurred, respectively, in 37.5% and 50.0% of localized juvenile periodontitis patients but not in healthy periodontal sites. 18 Periodontal cytomegalovirus and Epstein-Barr virus type-1 along with A. actinomycetemcomitans and P. gingivalis were identified in the only Hopi adolescent who exhibited generalized juvenile periodontitis.…”

Section: Clini C Al a S Pec Ts Of Herpe S Virus -Bac Terial Inter Ac ...mentioning

confidence: 99%

“…18 The two main periodontopathic bacteria A. actinomycetemcomitans and P. gingivalis occurred, respectively, in 37.5% and 50.0% of localized juvenile periodontitis patients but not in healthy periodontal sites. 18 Periodontal cytomegalovirus and Epstein-Barr virus type-1 along with A. actinomycetemcomitans and P. gingivalis were identified in the only Hopi adolescent who exhibited generalized juvenile periodontitis. Dual infections by periodontal cytomegalovirus-Epstein-Barr virus and by A. actinomycetemcomitans-P. gingivalis were also identified in an 11-year-old girl with Papillon-Lefèvre syndrome and severe periodontal breakdown on 10 of 22 erupted teeth.…”

Section: Clini C Al a S Pec Ts Of Herpe S Virus -Bac Terial Inter Ac ...mentioning

confidence: 99%

“…The clinical status and the subgingival microbiota of aggressive periodontitis were evaluated in 13-20-year-old subjects of the Hopi tribe reservation in Arizona (N = 75). 18 Juvenile periodontitis, identified by deep periodontal pockets and pattern of alveolar bone loss, occurred in 10.7% of Hopi teenagers.…”

Section: Clini C Al a S Pec Ts Of Herpe S Virus -Bac Terial Inter Ac ...mentioning

confidence: 99%

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Herpesvirus‐Bacteria pathogenic interaction in juvenile (aggressive) periodontitis. A novel etiologic concept of the disease

Slots

Rams

2023

Periodontology 2000

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Localized juvenile (aggressive) periodontitis starts at puberty in otherwise healthy individuals and involves the proximal surfaces of permanent incisors and first molars. The disease destroys a sizeable amount of periodontal bone within a few months despite minimal dental plaque and gingival tissue inflammation. Cytomegalovirus and Epstein–Barr virus, as well as the two main periodontopathic bacteria Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis, are linked to juvenile periodontitis. Juvenile periodontitis‐affected teeth show cementum hypoplasia. We hypothesize that an active herpesvirus infection, at the time of root formation, hampers cementum formation and, at puberty, herpesvirus reactivation triggers an upgrowth of bacterial pathogens which produce rapid periodontal destruction on teeth with a defective periodontium. A pathogenic interaction between active herpesviruses and bacterial pathogens can potentially explain the etiology and incisor‐first molar destructive pattern of juvenile periodontitis. Effective treatment of juvenile periodontitis may target the herpesvirus‐bacteria co‐infection.

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Frequency of Fimbrial Gene Types I, Ib, and II in Clinical Strains of Porphyromonas gingivalis Characterized From Periodontitis Patients

R.,

Girija,

Priyadharsini

et al. 2024

Cureus

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Objective Porphyromonas gingivalis ( P. gingivalis ) is considered the predominant pathogen in association with different stages of periodontitis, and fim genes play a vital role in adherence and colonization. This study is thus aimed to detect the prevalence of P. gingivalis and the frequency of fim gene types among the clinical strains isolated from periodontitis patients. Methods Plaque samples (N = 45) were collected from patients with three different stages of periodontitis (n = 15 in each group). All the samples were inoculated onto sterile anaerobic blood agar and were processed anaerobically using a GasPak system at 37°C for five to seven days. Standard microbiological techniques were used to identify P. gingivalis . Genomic DNA was extracted, and polymerase chain reaction (PCR) was carried out to detect the frequency of three fim gene types, using specific primers. Results P. gingivalis was more prevalent in Group III (93.3%), followed by 26.7% in Group II, and 13.3% in Group I. Maximum isolates were seen in the age group of 40-50, with no significance within the genders. fim type I was frequent in Group III (78.5% (n = 11)), followed by 0.25% (n = 1) under Group II, with no other fim types in the other groups. Conclusion Prevalence of P. gingivalis and frequency of fim genes, in association with its virulence, were observed. Periodical monitoring of such virulence genes would aid in the theranostic approach to combat the complications caused by P. gingivalis in periodontitis cases.

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Aggressive periodontitis in southwestern American Indian adolescents

Cited by 3 publications

References 44 publications

Elevated subgingival temperature infers high bacterial pathogen counts in severe periodontitis

Elevated subgingival temperature infers high bacterial pathogen counts in severe periodontitis

Herpesvirus‐Bacteria pathogenic interaction in juvenile (aggressive) periodontitis. A novel etiologic concept of the disease

Frequency of Fimbrial Gene Types I, Ib, and II in Clinical Strains of Porphyromonas gingivalis Characterized From Periodontitis Patients

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