Aggressive Osteoblastoma Involving the Navicular Bone of Foot: A Rare Tumor in a Unique Location

Rath, Ashutosh; Mandal, Shramana; Goswami, Sneha; Khurana, Nita; Dhal, Anil

doi:10.1053/j.jfas.2019.07.028

Cited by 2 publications

(5 citation statements)

References 15 publications

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“…Aggressive osteoblastomas are composed of an irregular network of bone trabeculae distributed in a loose stroma with prominent vasculature. 2,3,7,11,14,16,17 The most important histological finding is the presence of epithelioid osteoblasts that form solid sheets in intertrabecular spaces or rim osteoid trabeculae. Epithelioid osteoblasts are round cells with abundant eosinophilic cytoplasm, an eccentric, oval nucleus with prominent nucleoli, and some degree of atypia.…”

Section: Discussionmentioning

confidence: 99%

“…Epithelioid osteoblasts are round cells with abundant eosinophilic cytoplasm, an eccentric, oval nucleus with prominent nucleoli, and some degree of atypia. 2,3,7,11,14,16,17 Epithelioid osteoblasts are at least twice the size of normal osteoblasts and, frequently, show a large, clear cytoplasmic area with enlarged Golgi apparatus, which displaces the nucleus. 2,3,7,11,14,[16][17][18] Osteoid can be found around individual tumor cells or in broad zones surrounding epithelioid osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,7,11,14,16,17 Epithelioid osteoblasts are at least twice the size of normal osteoblasts and, frequently, show a large, clear cytoplasmic area with enlarged Golgi apparatus, which displaces the nucleus. 2,3,7,11,14,[16][17][18] Osteoid can be found around individual tumor cells or in broad zones surrounding epithelioid osteoblasts. The presence of benign osteoclast-like multinucleated giant cells and secondary aneurysmal bone cysts are common features.…”

Section: Discussionmentioning

confidence: 99%

“…Its peak age incidence is in the 2 nd and 3 rd decades of life. [1][2][3] Overall distribution patterns are similar to those of conventional osteoblastoma, with a predilection for the axial skeleton. The vertebral column, the sacrum, proximal parts of the appendicular skeleton such as the pelvis and femur, and jaw/craniofacial bones are primarily affected.…”

Section: Introductionmentioning

confidence: 98%

“…The vertebral column, the sacrum, proximal parts of the appendicular skeleton such as the pelvis and femur, and jaw/craniofacial bones are primarily affected. [2][3][4][5] Aggressive osteoblastomas do not metastasize, are likely to recur (in between 20 and 30% of cases) and are characterized by the presence of epithelioid osteoblasts. The lesion is not considered a precursor to osteosarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Aggressive Osteoblastoma of Temporal Bone Causing Facial Palsy in a 9-year-old Child: A Case Report Based on 2020 WHO Classification of Bone Tumors

Cambruzzi,

Furian,

Botega

et al. 2023

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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Aggressive osteoblastoma (AO) is an uncommon bone tumor that represents a borderline lesion between osteoblastoma and osteosarcoma. The vertebral column, the sacrum, the pelvis, and jaw/craniofacial bones are primarily affected. Aggressive osteoblastoma does not metastasize and is treated by surgical resection. The authors report a case of AO in a 9-year-old female patient presenting with 5th and 7th cranial nerve palsy. Prior pathological history included resection of an expansile nodule in the left temporal bone. Conventional radiological examination and computed tomography (CT) of the skull revealed an osteoblastic lesion arising in the petrous portion of the left temporal bone, measuring 5.2 cm in the largest dimension. The patient was subjected to partial surgical resection of the process. Microscopy revealed a primary neoplastic bone composed of numerous epithelioid round osteoblasts disposed in solid sheets and with mild atypia, large eosinophilic cytoplasm, and an eccentric, ovoid nucleus. The process exhibited loose stroma, low mitotic index, osteoid formation, and a few osteoclast-like multinucleated giant cells. The diagnosis of AO was thus established. After 5 months of clinical follow-up, the patient is asymptomatic, without evidence of tumoral growth on CT scans.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Aggressive Osteoblastoma of Temporal Bone Causing Facial Palsy in a 9-year-old Child: A Case Report Based on 2020 WHO Classification of Bone Tumors

Cambruzzi,

Furian,

Botega

et al. 2023

Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery

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A case of epithelioid osteoblastoma of the thoracic vertebra in a 12-year-old male: a case report and review of literature

Zaresharifi,

Karimzadhagh,

Reihanian

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and importance: Osteoblastoma (OB) is a rare benign bone tumor, representing less than 1% of all bone neoplasms. In contrast to the typical OB, a smaller subset known as “Epithelioid Osteoblastoma (EO)” exhibits a distinctive inclination for local invasion and recurrence. This rare variant can pose diagnostic challenges, particularly due to its unclear clinical and radiological presentation. Case presentation: This study details a clinical case of a 12-year-old boy experiencing pain from a lytic bone tumor located in the thoracic vertebrae (T3-T4), initially suggesting malignancy. Following extensive curettage, histopathological analysis confirmed the diagnosis of Epithelioid Osteoblastoma through immunohistochemical staining. Subsequent follow-up at three months revealed the absence of no pain or recurrence of the lesion. Clinical discussion: Distinguishing EO from a malignant tumor requires a multidisciplinary approach, considering clinical, radiographic, and histological features that differentiate the two entities. Conclusion: The goal of this case presentation is to increase awareness regarding this recurrent tumor variant, which poses diagnostic challenges, particularly in distinguishing it from malignant tumors, including osteosarcoma.

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Aggressive Osteoblastoma Involving the Navicular Bone of Foot: A Rare Tumor in a Unique Location

Cited by 2 publications

References 15 publications

Aggressive Osteoblastoma of Temporal Bone Causing Facial Palsy in a 9-year-old Child: A Case Report Based on 2020 WHO Classification of Bone Tumors

Aggressive Osteoblastoma of Temporal Bone Causing Facial Palsy in a 9-year-old Child: A Case Report Based on 2020 WHO Classification of Bone Tumors

A case of epithelioid osteoblastoma of the thoracic vertebra in a 12-year-old male: a case report and review of literature

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