Aggressive odontogenic epithelial neoplasm mimicking metastatic breast carcinoma: sclerosing odontogenic carcinoma?

Sclerosing odontogenic carcinoma — review of all published cases: is it a justifiable addition as a malignancy?

“…Sclerosing odontogenic carcinoma (SOC) was one of the new additions to the list of head and neck tumors by the World Health Organization 1 in 2017 and is defined as a primary intraosseous carcinoma of the jaws, with bland cytology, markedly sclerotic stroma and an aggressive infiltrative pattern. Although the first report of 3 cases was published in 2008 by Koutlas et al, 2 this terminology was first coined by Landwehr and Allen 3 in 1996 when they presented their case in the 50th Annual Meeting of the American Academy of Oral and Maxillofacial Pathology. Koutlas et al 4 presented 2 cases of SOC in the same meeting 9 years later.…”

A central maxillary tumor with bland cytology, partly sclerotic stroma, and neural involvement. Sclerosing odontogenic carcinoma or epithelial neurotropism in an odontogenic fibroma?

“…Sclerosing odontogenic carcinoma (SOC) is defined as “a primary intraosseous carcinoma of the jaws, with bland cytology, markedly sclerotic stroma, and aggressive infiltration.” 1 The first case was presented by Landwehr and Allen in 1996 2 as “an aggressive odontogenic epithelial neoplasm mimicking breast carcinoma.” Koutlas et al in 2008 3 detailed its microscopic features and established SOC as a distinct variety of odontogenic carcinoma that is included in 4th Edition of the World Health Organization (WHO) Classification of Head and Neck Tumors 1…”

Sclerosing odontogenic carcinoma

“…reported on what they considered to be a unique variant of PIOC under the name of SOC. Historically, one of three cases has been presented by Allen (the second author of the above paper 2 ) dating back to 1996 4 . Histologically, it is composed of a mixture of both epithelial and fibrous components.…”