Aggressive myoepithelial carcinoma with <i>EWSR1‐POU5F1</i> fusion highly responsive to Ewing sarcoma combination chemotherapy

Shenoy, Niraj

doi:10.1002/cncr.33220

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…However, FISH has helped with this distinction by demonstrating no evidence of fusion involving EWSR1, as seen in the case of CCC [47]. While it is considered to be chemoresistant, a study by Shenoy (2020) demonstrated that there is evidence of fusion between EWSR1 and POU5F1, a feature in tumors arising from visceral organs [80]. He stated that it can be treated with combination chemotherapy in the treatment of Ewing's sarcoma [80].…”

Section: Myoepithelial Carcinomamentioning

confidence: 99%

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

Iyer

Hariharan

Cao

et al. 2021

Cancers

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Salivary gland neoplasms (SGN) remain a diagnostic dilemma due to their heterogenic complex behavior. Their diverse histomorphological appearance is attributed to the underlying cellular mechanisms and differentiation into various histopathological subtypes with overlapping features. Diagnostic tools such as fine needle aspiration biopsy, computerized tomography, magnetic resonance imaging, and positron emission tomography help evaluate the structure and assess the staging of SGN. Advances in molecular pathology have uncovered genetic patterns and oncogenes by immunohistochemistry, fluorescent in situ hybridization, and next–generation sequencing, that may potentially contribute to innovating diagnostic approaches in identifying various SGN. Surgical resection is the principal treatment for most SGN. Other modalities such as radiotherapy, chemotherapy, targeted therapy (agents like tyrosine kinase inhibitors, monoclonal antibodies, and proteasome inhibitors), and potential hormone therapy may be applied, depending on the clinical behaviors, histopathologic grading, tumor stage and location, and the extent of tissue invasion. This review delves into the molecular pathways of salivary gland tumorigenesis, highlighting recent diagnostic protocols that may facilitate the identification and management of SGN.

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Section: Myoepithelial Carcinomamentioning

confidence: 99%

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

Iyer

Hariharan

Cao

et al. 2021

Cancers

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“…It has been proposed that the partly shared genetics of EWSR1 fusions may lend sensitivity to chemotherapy regimens used for Ewing sarcoma. We found a single case report 7 of early and deep radiologic response to this chemotherapy in a patient with metastatic EWSR1-POU5F1 fusion myoepithelial carcinoma. To the best of our knowledge, there are no reports of a similar response in malignancies with an EWSR1-ATF1 fusion.…”

Section: Discussionmentioning

confidence: 95%

Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

Gill

McKenzie

et al. 2021

JTO Clinical and Research Reports

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Malignant mesothelioma with EWSR1-ATF1 fusion is a rare malignancy described in young adults without asbestos exposure. To the best of our knowledge, outcomes to local and systemic therapies for this subtype of malignant mesothelioma have not been described. This case report describes the clinical course of a 19-year-old man diagnosed with malignant peritoneal mesothelioma with EWSR1-ATF1 fusion localized to the abdomen. His disease followed an aggressive course and resulted in limited survival (18 mo). There was treatment resistance to several lines of conventional local and systemic treatments for peritoneal mesothelioma and biologically targeted MET inhibition with crizotinib. More research is required in this rare subtype of peritoneal mesothelioma.

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“…Despite complete surgical resection, there is about a 43% rate of local recurrence [3] and a 40-50% rate of metastasis [9]. The use of combination chemotherapy to treat Ewing sarcoma (vincristine, doxorubicin, and cyclophosphamide alternating with ifosfamide and etoposide was seen to produce a dramatic response in EWSR-positive tumors [20].…”

Section: Discussionmentioning

confidence: 99%

Impending Doom: A Rare Case of Metastatic Myoepithelial Carcinoma

Ugwuegbulem¹,

Hlaing²,

deFreitas³

et al. 2022

Cureus

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Myoepithelial carcinoma is a rare malignant tumor arising from myoepithelial cells. The usual sites of occurrence are the oral cavity and pharynx with the majority of tumors arising from the salivary gland. However, there have been reported cases of myoepithelial carcinoma seen in the superficial soft tissue, upper respiratory tract, breast, skin, and GI tract. Deep soft tissue myoepithelial carcinoma is relatively uncommon.Due to the rarity of this malignancy, consensus on appropriate therapy remains sparse. However, complete resection and/or adjuvant chemotherapy and radiotherapy have been advocated for non-metastatic localized diseases. Sadly, the reported outcome in patients with metastatic disease remains dismal.In this case, we report a 79-year-old male incidentally found to have a deep soft tissue mass in the sacral area with a coexistent left axillary lymphadenopathy with biopsy and immunohistochemistry confirmation of metastatic myoepithelial carcinoma. He had a rapid clinical deterioration with subsequent fatality.

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Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy

Abstract: Patient, Julian Hargrove, provided permission and requested that his name and headshot be included with the article.

Cited by 6 publications

References 10 publications

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

An Overview on the Histogenesis and Morphogenesis of Salivary Gland Neoplasms and Evolving Diagnostic Approaches

Malignant Peritoneal Mesothelioma With EWSR1-ATF1 Fusion: A Case Report

Impending Doom: A Rare Case of Metastatic Myoepithelial Carcinoma

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